Abstract

We propose a laser speckle projection tomography (LSPT) method to obtain a three-dimensional (3D) flowing image. The method combines the advantages of optical projection tomography and laser speckle imaging to reconstruct the visualization of 3D flowing structure. With LSPT, the flowing signal is extracted by laser speckle contrast method and the 3D flowing image is reconstructed by the filtered back-projection algorithm. A phantom experiment is performed to demonstrate that LSPT is able to obtain 3D flowing structure, influenced by concentration and the flow speed.

© 2013 Optical Society of America

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References

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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
  6. J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
    [CrossRef]
  7. Y. Wang and R. Wang, Phys. Med. Biol. 51, 6023 (2006).
    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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2012 (1)

2011 (3)

J. McGinty, H. B. Taylor, L. Chen, L. Bugeon, J. R. Lamb, M. J. Dallman, and P. M. W. French, Biomed. Opt. Express 2, 1340 (2011).
[CrossRef]

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

2009 (1)

J. Francois and J. Sharpe, Organogenesis 5, 211 (2009).

2008 (1)

2006 (3)

Y. Wang and R. Wang, Phys. Med. Biol. 51, 6023 (2006).
[CrossRef]

N. Fomin, E. Lavinskaya, and K. Takayama, Opt. Lasers Eng. 44, 335 (2006).
[CrossRef]

P. Li, S. Ni, L. Zhang, S. Zeng, and Q. Luo, Opt. Lett. 31, 1824 (2006).
[CrossRef]

2005 (1)

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

2002 (1)

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

1995 (1)

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Ahlgren, U.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Baldock, R.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Bassi, A.

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Birk, U. J.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Briers, J. D.

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Bugeon, L.

Chen, L.

Cheng, H.

D’Andrea, C.

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Dallman, M. J.

Davidson, D.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Duong, T. Q.

Fieramonti, L.

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Fomin, N.

N. Fomin, E. Lavinskaya, and K. Takayama, Opt. Lasers Eng. 44, 335 (2006).
[CrossRef]

Francois, J.

J. Francois and J. Sharpe, Organogenesis 5, 211 (2009).

French, P. M. W.

Hecksheret-SØrensen, J.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Henderson, M.

Henkelman, R. M.

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

Hill, B.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Kak, A. C.

A. C. Kak and M. Slaney, Principles of Computerized Tomographic Imaging (IEEE, 1988).

Lamb, J. R.

Lavinskaya, E.

N. Fomin, E. Lavinskaya, and K. Takayama, Opt. Lasers Eng. 44, 335 (2006).
[CrossRef]

Li, P.

Luo, Q.

McGinty, J.

Meyer, H.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Mione, M.

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Moyer, A.

Ni, S.

Perry, P.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Rieckher, M.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Ripoll, J.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Sharpe, J.

J. Francois and J. Sharpe, Organogenesis 5, 211 (2009).

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Slaney, M.

A. C. Kak and M. Slaney, Principles of Computerized Tomographic Imaging (IEEE, 1988).

Sled, J. G.

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

Takayama, K.

N. Fomin, E. Lavinskaya, and K. Takayama, Opt. Lasers Eng. 44, 335 (2006).
[CrossRef]

Tavernarakis, N.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Taylor, H. B.

Valentini, G.

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Walls, J. R.

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

Wang, D.

Wang, R.

Y. Wang and R. Wang, Phys. Med. Biol. 51, 6023 (2006).
[CrossRef]

Wang, Y.

Y. Wang and R. Wang, Phys. Med. Biol. 51, 6023 (2006).
[CrossRef]

Webster, S.

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Yan, Y.

Zeng, S.

Zhang, L.

Appl. Opt. (1)

Biomed. Opt. Express (1)

J. Biomed. Opt. (1)

A. Bassi, L. Fieramonti, C. D’Andrea, M. Mione, and G. Valentini, J. Biomed. Opt. 16, 100502 (2011).
[CrossRef]

Opt. Commun. (1)

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Opt. Express (1)

Opt. Lasers Eng. (1)

N. Fomin, E. Lavinskaya, and K. Takayama, Opt. Lasers Eng. 44, 335 (2006).
[CrossRef]

Opt. Lett. (1)

Organogenesis (1)

J. Francois and J. Sharpe, Organogenesis 5, 211 (2009).

Phys. Med. Biol. (2)

J. R. Walls, J. G. Sled, J. Sharpe, and R. M. Henkelman, Phys. Med. Biol. 50, 4645 (2005).
[CrossRef]

Y. Wang and R. Wang, Phys. Med. Biol. 51, 6023 (2006).
[CrossRef]

PLoS One (1)

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef]

Science (1)

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, J. Hecksheret-SØrensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef]

Other (1)

A. C. Kak and M. Slaney, Principles of Computerized Tomographic Imaging (IEEE, 1988).

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Figures (4)

Fig. 1.
Fig. 1.

(a) Schematic of the LSPT used in our experiments. (b) The flow phantom with two polyethene tubes.

Fig. 2.
Fig. 2.

(a) Raw image illuminated by laser. (b) The contrast image of (a). (c) The transmission image illuminated by white light. (d) The image based on the digital motion analysis of (c).

Fig. 3.
Fig. 3.

(a) Reconstructed cross-sectional OPT image. (b) Reconstructed cross-sectional LSPT image. Curves (c) and (d) along the horizontal dashed line indicate (a) and (b). (e) 3D OPT image. (f) 3D LSPT image.

Fig. 4.
Fig. 4.

(a) Different intralipid concentration LSPT image, tubes C and D with concentration 1% and 0.5%, respectively. (b) Different flow speed LSPT image, tubes E and F with velocity 3mm/s and 0.5mm/s, respectively. Curves (c) and (d) along the horizontal dashed line indicate (a) and (b).

Equations (2)

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K(x,y)=1N1{i=1N[Ix,y(n)Ix,y]2}Ix,y,
K(x,z)=0πP(l,θ)*c(l)×δ(xcosθ+zsinθl)dldθ,

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