Abstract

The use of anatomical priors in fluorescence tomography is known to improve image quality and accuracy significantly. However, the use of prior information is often implemented by incorporating user segmented structural images into the optical reconstruction algorithm, a process requiring significant time and expertise. We propose an automated implementation which encodes the gray-scale prior image directly into the regularization term, eliminating the need for direct prior image segmentation, which is extendable to any spatially defined prior data. The proposed method is supported by in vivo studies.

© 2013 Optical Society of America

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2012 (1)

2011 (1)

2010 (4)

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, Biomed. Opt. Express 1, 223 (2010).
[CrossRef]

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

2009 (1)

2007 (1)

2005 (1)

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Abascal, J.

Aguirre, J.

Ale, A.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

Arridge, S.

Arridge, S. R.

Boas, D. A.

Brooksby, B.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Chamorro-Servent, J.

Correia, T.

Davis, S.

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Davis, S. C.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007).
[CrossRef]

Dehghani, H.

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Desco, M.

Fang, Q.

Ghadyani, H. R.

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Gibbs-Strauss, S. L.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Gibson, A. P.

Hoopes, P. J.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Jermyn, M.

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Jiang, S.

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Katamreddy, S. H.

Kogel, C.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Kolehmainen, V.

Kopans, D. B.

Leahy, R. M.

Mastanduno, M. A.

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Moore, R. H.

Ntziachristos, V.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

O’Hara, J. A.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Panagiotou, C.

Paulsen, K. D.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Payne, H. L.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Pogue, B.

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

Pogue, B. W.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, Opt. Express 15, 4066 (2007).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Poplack, S. P.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Samkoe, K. S.

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Sarantopoulos, A.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

Schulz, R. B.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

Schweiger, M.

Sisniega, A.

Somayajula, S.

Vaquero, J. J.

Wang, J.

Weaver, J.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

Yalavarthy, P. K.

Acad. Radiol. (1)

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, H. L. Payne, P. J. Hoopes, K. D. Paulsen, and B. W. Pogue, Acad. Radiol. 17, 271 (2010).
[CrossRef]

Biomed. Opt. Express (2)

J. Biomed. Opt. (2)

S. C. Davis, K. S. Samkoe, J. A. O’Hara, S. L. Gibbs-Strauss, K. D. Paulsen, and B. W. Pogue, J. Biomed. Opt. 15, 051602 (2010).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, J. Biomed. Opt. 10, 051504 (2005).
[CrossRef]

J. Opt. Soc. Am. A (2)

Med. Phys. (1)

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, Med. Phys. 37, 1976 (2010).
[CrossRef]

Opt. Express (1)

Other (1)

M. Jermyn, B. Pogue, H. R. Ghadyani, S. Davis, M. A. Mastanduno, and H. Dehghani, A User-Enabling Visual Workflow for Near-Infrared Light Transport Modeling in Tissue (Optical Society of America, 2012), paper BW1A.7.

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Figures (3)

Fig. 1.
Fig. 1.

Structural images from gadolinium-enhanced MRI showing characteristic ring enhancement for (a) subject 1 and (b) subject 2. Segmented regions are shown in (c) and (d) and define the head and brain Gd-enhanced region surrounding a probable necrotic region.

Fig. 2.
Fig. 2.

Fluorescent recovery using only the surface shape of the subject (top row), Laplacian regularization using the regions in Fig. 1 (row 2), and the proposed method using the structural image information directly (third row), for subject 1 (left column) and subject 2 (right column).

Fig. 3.
Fig. 3.

Comparison of fluorescence recovery with changing gray-scale parameter using the proposed method. Too small of a parameter will create artifacts due to the inherent inhomogeneity of medical images. As the parameter grows, the no-priors case is recovered.

Equations (2)

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S(x)=f(x)d22+λLx22,
Lij={1,i=j1Miexp(|γiγj|22σg2),otherwise,

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