Abstract

We experimentally demonstrate an all-diffractive optical setup for digital lensless holographic microscopy with easy wavelength line selection and micrometric resolution. In the proposed system, an ultrashort laser pulse is focused with a diffractive lens (DL) onto a pinhole of diameter close to its central wavelength to achieve a highly spatially coherent illumination cone as well as a spectral line with narrow width. To scan the complete spectrum of the light source the DL is displaced with respect to the pinhole plane. The proposed microscopy setup allows us to spectrally separate contributions from different sections of a sample, which may be attractive for several applications in life sciences.

© 2013 Optical Society of America

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  1. J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
    [CrossRef]
  2. D. Gabor, Nature 161, 777 (1948).
    [CrossRef]
  3. J. W. Goodman and R. W. Lawrence, Appl. Phys. Lett. 11, 77 (1967).
    [CrossRef]
  4. S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
    [CrossRef]
  5. S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
    [CrossRef]
  6. J. F. Restrepo and J. Garcia-Sucerquia, Opt. Lett. 37, 752 (2012).
    [CrossRef]
  7. M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
    [CrossRef]
  8. J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
    [CrossRef]
  9. M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).
  10. M. K. Kim, Opt. Lett. 24, 1693 (1999).
    [CrossRef]
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    [CrossRef]
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    [CrossRef]
  13. G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
    [CrossRef]
  14. N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
    [CrossRef]
  15. M. H. Jericho and H. J. Kreuzer, in Coherent Light Microscopy, P. Ferraro, A. Wax, and Z. Zalevvsky, eds. (Springer, 2011), pp. 3–30.

2012 (3)

2011 (1)

J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
[CrossRef]

2010 (1)

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

2009 (2)

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

2006 (2)

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

2001 (1)

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

1999 (1)

1995 (1)

N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
[CrossRef]

1967 (1)

J. W. Goodman and R. W. Lawrence, Appl. Phys. Lett. 11, 77 (1967).
[CrossRef]

1948 (1)

D. Gabor, Nature 161, 777 (1948).
[CrossRef]

Ameur, K. A.

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

Andrés, P.

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

Bearman, G.

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

Brunel, M.

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

Coetmellec, S.

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

Dickinson, M. E.

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

Dumas, E. M.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

Fraser, S. E.

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

Gabor, D.

D. Gabor, Nature 161, 777 (1948).
[CrossRef]

Garcia-Sucerquia, J.

Goodman, J. W.

J. W. Goodman and R. W. Lawrence, Appl. Phys. Lett. 11, 77 (1967).
[CrossRef]

Jericho, M. H.

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

M. H. Jericho and H. J. Kreuzer, in Coherent Light Microscopy, P. Ferraro, A. Wax, and Z. Zalevvsky, eds. (Springer, 2011), pp. 3–30.

Jericho, S. K.

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

Jerico, M. H.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

Jerico, S. K.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

Kim, M. K.

Kitaura, N.

N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
[CrossRef]

Klages, P.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

Kreuzer, H. J.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

M. H. Jericho and H. J. Kreuzer, in Coherent Light Microscopy, P. Ferraro, A. Wax, and Z. Zalevvsky, eds. (Springer, 2011), pp. 3–30.

Lancis, J.

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

Lansford, R.

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

Lawrence, R. W.

J. W. Goodman and R. W. Lawrence, Appl. Phys. Lett. 11, 77 (1967).
[CrossRef]

Lebrum, D.

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

McDonnell, S.

J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
[CrossRef]

McDonnelle, S.

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Mendoza-Yero, O.

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

Mínguez-Vega, G.

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

Molonyd, K. M.

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Mori, Y.

N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
[CrossRef]

Nadeau, J.

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

Naughtond, T. J.

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Ogata, S.

N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
[CrossRef]

Restrepo, J. F.

Ryle, J. P.

J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
[CrossRef]

Rylea, J. P.

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Shen, H.

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

Sheridan, J. T.

J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
[CrossRef]

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Tajahuerce, E.

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

Tille, S.

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

Xu, W.

J. Garcia-Sucerquia, W. Xu, S. K. Jericho, P. Klages, M. H. Jericho, and H. J. Kreuzer, Appl. Opt. 45, 836 (2006).
[CrossRef]

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

Appl. Opt. (1)

Appl. Phys. B (1)

M. Brunel, H. Shen, S. Coetmellec, D. Lebrum, and K. A. Ameur, Appl. Phys. B 106, 583 (2012).
[CrossRef]

Appl. Phys. Lett. (1)

J. W. Goodman and R. W. Lawrence, Appl. Phys. Lett. 11, 77 (1967).
[CrossRef]

Bioimaging (1)

M. E. Dickinson, G. Bearman, S. Tille, R. Lansford, and S. E. Fraser, Bioimaging 31, 1272 (2001).

IEEE Photon. Technol. Lett. (1)

G. Mínguez-Vega, O. Mendoza-Yero, E. Tajahuerce, J. Lancis, and P. Andrés, IEEE Photon. Technol. Lett. 21, 347 (2009).
[CrossRef]

J. Biomed. Opt. (1)

J. P. Ryle, S. McDonnell, and J. T. Sheridan, J. Biomed. Opt. 16, 126004 (2011).
[CrossRef]

Nature (1)

D. Gabor, Nature 161, 777 (1948).
[CrossRef]

Opt. Eng. (1)

N. Kitaura, S. Ogata, and Y. Mori, Opt. Eng. 34, 584 (1995).
[CrossRef]

Opt. Lett. (3)

Planet. Space Sci. (1)

S. K. Jerico, P. Klages, J. Nadeau, E. M. Dumas, M. H. Jerico, and H. J. Kreuzer, Planet. Space Sci. 58, 701 (2010).
[CrossRef]

Proc. SPIE (1)

J. P. Rylea, K. M. Molonyd, S. McDonnelle, T. J. Naughtond, and J. T. Sheridan, Proc. SPIE 7442, 744206 (2009).
[CrossRef]

Rev. Sci. Instrum. (1)

S. K. Jericho, J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, Rev. Sci. Instrum. 77, 043706 (2006).
[CrossRef]

Other (1)

M. H. Jericho and H. J. Kreuzer, in Coherent Light Microscopy, P. Ferraro, A. Wax, and Z. Zalevvsky, eds. (Springer, 2011), pp. 3–30.

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Figures (3)

Fig. 1.
Fig. 1.

Schematic of the diffractive DLHM.

Fig. 2.
Fig. 2.

Reconstructed hologram of a section of the head of a fruit fly for the spectral line centered at 780 nm. Top left: details of the head structure. Bottom left: profile of the pulse spectrum and the selected spectral line.

Fig. 3.
Fig. 3.

Pseudo-colored RGB image of a section of the head of the fruit fly obtained from the merging of images corresponding to the spectral lines at 860, 800, and 740 nm.

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