Abstract

We present a lateral laser speckle contrast analysis method combined with line beam scanning illumination to improve the sampling depth of blood flow imaging. Both the phantom and animal experimental results suggest that localized illumination and lateral speckle contrast analysis can significantly enhance the deep blood flow signal to improve the sampling depth of laser speckle contrast imaging compared with the traditional full-field illumination laser speckle contrast analysis method.

© 2012 Optical Society of America

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  1. B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
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  2. D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010).
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  4. J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
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  5. A. K. Dunn and D. A. Boas, Opt. Lett. 25, 1777 (2000).
    [CrossRef]
  6. A. Mazhar, D. J. Cuccia, T. B. Rice, S. A. Carp, A. J. Durkin, D. A. Boas, B. Choi, and B. J. Tromberg, Biomed. Opt. Express 2, 1553 (2011).
    [CrossRef]
  7. M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
    [CrossRef]
  8. J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
    [CrossRef]
  9. J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996).
    [CrossRef]
  10. A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
    [CrossRef]
  11. R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
    [CrossRef]
  12. S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
    [CrossRef]
  13. W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
    [CrossRef]

2011 (1)

2010 (3)

M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
[CrossRef]

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010).
[CrossRef]

2009 (1)

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

2007 (1)

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

2005 (1)

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

2001 (2)

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

J. D. Briers, Physiol. Meas. 22, R35 (2001).
[CrossRef]

2000 (1)

1996 (1)

J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996).
[CrossRef]

1993 (1)

S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
[CrossRef]

1990 (1)

W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
[CrossRef]

Bandyopadhyay, R.

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

Boas, D. A.

A. Mazhar, D. J. Cuccia, T. B. Rice, S. A. Carp, A. J. Durkin, D. A. Boas, B. Choi, and B. J. Tromberg, Biomed. Opt. Express 2, 1553 (2011).
[CrossRef]

D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010).
[CrossRef]

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

A. K. Dunn and D. A. Boas, Opt. Lett. 25, 1777 (2000).
[CrossRef]

Bolay, H.

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

Briers, J. D.

J. D. Briers, Physiol. Meas. 22, R35 (2001).
[CrossRef]

J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996).
[CrossRef]

Carp, S. A.

Chance, B.

S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
[CrossRef]

Channual, J.

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

Cheong, W.

W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
[CrossRef]

Choi, B.

Clancy, N. T.

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

Cuccia, D. J.

Dixon, P. K.

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

Doherty, J. O.

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

Dunn, A. K.

D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010).
[CrossRef]

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

A. K. Dunn and D. A. Boas, Opt. Lett. 25, 1777 (2000).
[CrossRef]

Durian, D. J.

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

Durkin, A. J.

Enfield, J. G.

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

Feng, S.

S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
[CrossRef]

Gittings, A. S.

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

Gratton, E.

M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
[CrossRef]

Jia, W.

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

Kelly, K. M.

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

Leahy, M. J.

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

Li, P.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Lotfi, J.

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

Luo, Q.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Luo, W.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Mantulin, W. W.

M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
[CrossRef]

Mazhar, A.

McNamara, P.

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

Moskowitz, M. A.

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

Prahl, S. A.

W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
[CrossRef]

Qiu, J.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Rice, T. B.

Rossow, M. J.

M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
[CrossRef]

Suh, S. S.

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

Tromberg, B. J.

Wang, J.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Webster, S.

J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996).
[CrossRef]

Welch, A. J.

W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
[CrossRef]

Zeng, F.

S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
[CrossRef]

Zhang, H.

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

Biomed. Opt. Express (1)

J. Biomed. Opt. (5)

M. J. Rossow, W. W. Mantulin, and E. Gratton, J. Biomed. Opt. 15, 026003 (2010).
[CrossRef]

J. Qiu, P. Li, W. Luo, J. Wang, H. Zhang, and Q. Luo, J. Biomed. Opt. 15, 016003 (2010).
[CrossRef]

J. D. Briers and S. Webster, J. Biomed. Opt. 1, 174 (1996).
[CrossRef]

D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010).
[CrossRef]

J. O. Doherty, P. McNamara, N. T. Clancy, J. G. Enfield, and M. J. Leahy, J. Biomed. Opt. 14, 034025 (2009).
[CrossRef]

J. Cereb. Blood Flow Metab. (1)

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef]

J. Invest. Dermatol. (1)

B. Choi, W. Jia, J. Channual, K. M. Kelly, and J. Lotfi, J. Invest. Dermatol. 128, 846 (2007).
[CrossRef]

Opt. Lett. (1)

Physiol. Meas. (1)

J. D. Briers, Physiol. Meas. 22, R35 (2001).
[CrossRef]

Proc. IEEE (1)

W. Cheong, S. A. Prahl, and A. J. Welch, Proc. IEEE 26, 2166 (1990).
[CrossRef]

Proc. SPIE (1)

S. Feng, F. Zeng, and B. Chance, Proc. SPIE 1888, 78 (1993).
[CrossRef]

Rev. Sci. Instrum. (1)

R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005).
[CrossRef]

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Figures (4)

Fig. 1.
Fig. 1.

Schematic of the experimental setup.

Fig. 2.
Fig. 2.

(a) Procedure of lateral speckle contrast analysis method. (b) Relationship between the depth sensitivity and source–detector distance. (c) Relationship between the mean depth of the photon packet and the source-–detector separation. (d) Probability density distributions of mean depths that the detected photons traveled inside the medium.

Fig. 3.
Fig. 3.

(a)–(c) Blood flow images obtained by traditional method, the lateral speckle contrast analysis method weighted with constant and deep depth sensitivity curves, respectively. (d) Profiles of the velocity along the horizontal dashed lines indicated in (a)–(c).

Fig. 4.
Fig. 4.

(a) Schematic of the tissue like phantom. (b) Velocity images with lateral speckle contrast analysis method. (c)–(d) Velocity images with full-field method without and with cross-polarization, respectively.

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