Abstract

We present optitrode, a miniaturized flexible probe for integrated, localized light delivery and electrical recording. This device features an annular light guide with transparent polymer and fused silica layers surrounding a twisted-wire tetrode. We have developed a novel fabrication process, V-groove guided capillary assembly, to achieve high-precision, coaxial alignment of the various layers of the device. Optitrode with a length-to-diameter ratio ∼500 (5 cm long, 100 μm diameter) has been fabricated, and both the electrical and optical functions have been characterized. The prototype can deliver 11% (110 mW) of the total laser power under abrupt bending angle ∼25°.

© 2012 Optical Society of America

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  1. C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).
  2. T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).
  3. F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
    [CrossRef]
  4. K. Deisseroth, Nat. Methods 8, 26 (2011).
    [CrossRef]
  5. S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
    [CrossRef]
  6. Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
    [CrossRef]
  7. I.-J. Cho, H. W. Baac, and E. Yoon, in IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS), pp. 995–998 (2010).
  8. S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).
  9. J. C. McDonald and G. M. Whitesides, Acc. Chem. Res. 35, 491 (2002).
    [CrossRef]
  10. F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
    [CrossRef]

2011

K. Deisseroth, Nat. Methods 8, 26 (2011).
[CrossRef]

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

2010

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

2009

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

2007

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

2006

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

2002

J. C. McDonald and G. M. Whitesides, Acc. Chem. Res. 35, 491 (2002).
[CrossRef]

1995

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

Baac, H. W.

I.-J. Cho, H. W. Baac, and E. Yoon, in IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS), pp. 995–998 (2010).

Bamberg, E.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Barbic, M.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Bories, C.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Boyden, E. S.

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

Brauner, M.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Buzsaki, G.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Cho, I.-J.

I.-J. Cho, H. W. Baac, and E. Yoon, in IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS), pp. 995–998 (2010).

Dani, J. A.

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

Dani, J.A.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

De Koninck, Y.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Deisseroth, K.

K. Deisseroth, Nat. Methods 8, 26 (2011).
[CrossRef]

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

Deschenes, M.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Dufour, S.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Gheewala, M.

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

Gottschalk, A.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Gray, C. M.

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

Kay, K.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Lavertu, G.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

LeChasseur, Y.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Liang, Y.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

Liewald, J. F.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Lin, S.-T.

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

Losonczy, A.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Magee, J. C.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Maldonado, P. E.

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

McDonald, J. C.

J. C. McDonald and G. M. Whitesides, Acc. Chem. Res. 35, 491 (2002).
[CrossRef]

McNaughton, B.

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

Nagel, G.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Royer, S.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Shih, W.-C.

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

Siapas, A.G.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

Vallee, R.

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

Wang, L.-P.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

Watzke, N.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Whitesides, G. M.

J. C. McDonald and G. M. Whitesides, Acc. Chem. Res. 35, 491 (2002).
[CrossRef]

Wilson, M.

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

Wolfe, J. C.

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

Wood, P. G.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Yoon, E.

I.-J. Cho, H. W. Baac, and E. Yoon, in IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS), pp. 995–998 (2010).

Zemelman, B. V.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

Zhang, F.

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

Zhang, L.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

Zhang, T.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

Zhou, F.-M.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

Acc. Chem. Res.

J. C. McDonald and G. M. Whitesides, Acc. Chem. Res. 35, 491 (2002).
[CrossRef]

Eur. J. Neurosci.

S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279 (2010).
[CrossRef]

J. Neurosci.

T. Zhang, L. Zhang, Y. Liang, A.G. Siapas, F.-M. Zhou, and J.A. Dani, J. Neurosci. 29, 4035 (2009).

J. Neurosci. Methods

C. M. Gray, P. E. Maldonado, M. Wilson, and B. McNaughton, J. Neurosci. Methods 63, 43 (1995).

Nat. Methods

K. Deisseroth, Nat. Methods 8, 26 (2011).
[CrossRef]

Y. LeChasseur, S. Dufour, G. Lavertu, C. Bories, M. Deschenes, R. Vallee, and Y. De Koninck, Nat. Methods 8, 319 (2011).
[CrossRef]

F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, Nat. Methods 3, 785 (2006).
[CrossRef]

Nature

F. Zhang, L.-P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007).
[CrossRef]

Other

I.-J. Cho, H. W. Baac, and E. Yoon, in IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS), pp. 995–998 (2010).

S.-T. Lin, M. Gheewala, J. C. Wolfe, J. A. Dani, and W.-C. Shih, in 5th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 700–703 (2011).

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