Abstract

Pulse inversion acoustic imaging is useful as it allows second harmonic imaging to be obtained with short acoustic pulses. This allows high axial resolution, but removes any overlap in the frequency spectra of fundamental and harmonic. We demonstrate pulse inversion ultrasound modulated optical tomography using an optical speckle based detection method. Inverted and non-inverted acoustic pulses combined with synchronized strobed illumination are applied to an optically scattering medium. Over the acquisition time of a camera, multiple pulses are summed and at the next frame the phase of the ultrasound is shifted by π/2 and the process repeated. Combining the two frames allows a second harmonic signal to be obtained. A reduction in linewidth is observed (DC=9.26mm, fundamental=4.02mm, second harmonic=2.43mm) in line scans of optically absorbing objects embedded in a scattering medium (thickness=16mm, scattering coefficient=2.3mm1, anisotropy factor=0.938).

© 2012 Optical Society of America

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2008

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

2006

M. Hisaka, Appl. Phys. Lett. 88, 033901 (2006).
[CrossRef]

2005

2002

1999

D. H. Simpson, C. T. Chin, and P. N. Burns, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 372 (1999).
[CrossRef]

S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
[CrossRef]

1998

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

1997

B. Ward, A. C. Baker, and V. F. Humphrey, J. Acoust. Soc. Am. 101, 143 (1997).
[CrossRef]

L. V. Wang and X. Zhao, Appl. Opt. 36, 7277 (1997).
[CrossRef]

1995

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

1989

M. J. W. Povey, J. Food Eng. 9, 1 (1989).
[CrossRef]

1983

S. M. Bentzen, Med. Phys. 10, 579 (1983).
[CrossRef]

Atlan, M.

Baker, A. C.

B. Ward, A. C. Baker, and V. F. Humphrey, J. Acoust. Soc. Am. 101, 143 (1997).
[CrossRef]

Bentzen, S. M.

S. M. Bentzen, Med. Phys. 10, 579 (1983).
[CrossRef]

Blackstock, D. T.

M. F. Hamilton and D. T. Blackstock, Nonlinear Acoustics (Academic, 1997).

Boccara, A. C.

Burns, P. N.

D. H. Simpson, C. T. Chin, and P. N. Burns, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 372 (1999).
[CrossRef]

Chin, C. T.

D. H. Simpson, C. T. Chin, and P. N. Burns, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 372 (1999).
[CrossRef]

Delaye, P.

Duck, F. A.

F. A. Duck, Ultrasound Med. Biol. 28, 1 (2002).
[CrossRef]

Forget, B. C.

Gross, M.

Hamilton, M. F.

M. F. Hamilton and D. T. Blackstock, Nonlinear Acoustics (Academic, 1997).

Hedrick, W. R.

W. R. Hedrick and L. Metzger, J. Diagn. Med. Sonogr. 21, 183 (2005).
[CrossRef]

Hemmer, P.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

Hisaka, M.

M. Hisaka, Appl. Phys. Lett. 88, 033901 (2006).
[CrossRef]

Humphrey, V. F.

B. Ward, A. C. Baker, and V. F. Humphrey, J. Acoust. Soc. Am. 101, 143 (1997).
[CrossRef]

Kampmann, W.

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

Kim, C.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

Lebec, M.

Leutz, W.

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Leveque, S.

Li, J.

Li, Y.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

Maret, G.

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Metzger, L.

W. R. Hedrick and L. Metzger, J. Diagn. Med. Sonogr. 21, 183 (2005).
[CrossRef]

Obladen, M.

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

Pottier, L.

Povey, M. J. W.

M. J. W. Povey, J. Food Eng. 9, 1 (1989).
[CrossRef]

Ramaz, F.

Roosen, G.

Saint-Jalmes, H.

Selb, J.

Simpson, D. H.

D. H. Simpson, C. T. Chin, and P. N. Burns, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 372 (1999).
[CrossRef]

van de Hulst, H. C.

H. C. van de Hulst, Light Scattering by Small Particles(Dover, 1981).

Vogel, M.

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

Wagner, K. H.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

Walka, M. M.

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

Wang, L. V.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

J. Li and L. V. Wang, Appl. Opt. 41, 2079 (2002).
[CrossRef]

L. V. Wang and X. Zhao, Appl. Opt. 36, 7277 (1997).
[CrossRef]

Ward, B.

B. Ward, A. C. Baker, and V. F. Humphrey, J. Acoust. Soc. Am. 101, 143 (1997).
[CrossRef]

Zhang, H.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

Zhao, X.

Appl. Opt.

Appl. Phys. Lett.

Y. Li, H. Zhang, C. Kim, K. H. Wagner, P. Hemmer, and L. V. Wang, Appl. Phys. Lett. 93, 011111 (2008).
[CrossRef]

M. Hisaka, Appl. Phys. Lett. 88, 033901 (2006).
[CrossRef]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control

D. H. Simpson, C. T. Chin, and P. N. Burns, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 372 (1999).
[CrossRef]

J. Acoust. Soc. Am.

B. Ward, A. C. Baker, and V. F. Humphrey, J. Acoust. Soc. Am. 101, 143 (1997).
[CrossRef]

J. Diagn. Med. Sonogr.

W. R. Hedrick and L. Metzger, J. Diagn. Med. Sonogr. 21, 183 (2005).
[CrossRef]

J. Food Eng.

M. J. W. Povey, J. Food Eng. 9, 1 (1989).
[CrossRef]

Med. Phys.

S. M. Bentzen, Med. Phys. 10, 579 (1983).
[CrossRef]

Opt. Express

Opt. Lett.

Physica B

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Ultrasound Med. Biol.

W. Kampmann, M. M. Walka, M. Vogel, and M. Obladen, Ultrasound Med. Biol. 24, 1169 (1998).
[CrossRef]

F. A. Duck, Ultrasound Med. Biol. 28, 1 (2002).
[CrossRef]

Other

M. F. Hamilton and D. T. Blackstock, Nonlinear Acoustics (Academic, 1997).

H. C. van de Hulst, Light Scattering by Small Particles(Dover, 1981).

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Figures (3)

Fig. 1.
Fig. 1.

(a) 0 and π US pulse pairs are input to the US transducer (top trace), which are strobed after time Td (second trace). This occurs 1000 times over the exposure time Te of the camera. In the next camera frame, π/2 and 3π/2 pulse pairs are applied and are again strobed. Ti=interval time between acoustic pulses. (b) Experiment set up. FG, function generator; PA, power amplifier; UT, US transducer; LD, laser diode; ST, stage; AP, aperture; CA, camera; and PC, computer.

Fig. 2.
Fig. 2.

(a) Cut-away of two absorbing rods embedded in the scattering gel; and (b) comparison of line scans.

Fig. 3.
Fig. 3.

(a) Line-spread functions obtained by USMOT (b) Line-spread function obtained from hydrophone scans of US.

Equations (7)

Equations on this page are rendered with MathJax. Learn more.

I0,i=IMsin(2ωaTd+φi),
I1,i=IMsin(2ωaTd+φi+π).
I0,iI1,i=2IMsin(2ωaTd+φi).
(I0,iI1,i)2=2IM2,
IM=[(I0,iI1,i)22]12,
s=IMIdc,
s=[(I0,iI1,i)22]12(I0,i+I1,i)/2

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