Abstract

We demonstrate a novel multifunctional optical system that is capable of trapping, imaging, position sensing, and fluorescence detection of micrometer-sized fluorescent test particles using hollow-core photonic crystal fiber (HC-PCF). This multifunctional optical system for trapping, position sensing, and fluorescent detection is designed such that a near-IR laser light is used to create an optical trap across a liquid-filled HC-PCF, and a 473 nm laser is employed as a source for fluorescence excitation. This proposed system and the obtained results are expected to significantly enable an efficient integrated trapping platform employing HC-PCF for diagnostic biomedical applications.

© 2012 Optical Society of America

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    [CrossRef]

2012 (1)

V. K. Shinoj and V. M. Murukeshan, J. Appl. Phys. 111, 023106 (2012).
[CrossRef]

2011 (2)

2010 (1)

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

2009 (1)

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

2008 (1)

H. Zhang and K.-K. Liu, J. R. Soc. Interface 5, 671 (2008).
[CrossRef]

2007 (3)

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

J. Tuominen, H. J. Hoffrén, and H. Ludvigsen, J. Eur. Opt. Soc. Rapid Publ. 2, 07016 (2007).
[CrossRef]

S. Smolka, M. Barth, and O. Benson, Opt. Express 15, 12783 (2007).
[CrossRef]

2005 (1)

2001 (1)

A. J. Tüdös, G. A. J. Besselink, and R. B. M. Schasfoort, Lab Chip 1, 83 (2001).
[CrossRef]

2000 (1)

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

1994 (1)

K. Svoboda and S. M. Block, Ann. Rev. Biophys. Biomol. Struct. 23, 247 (1994).
[CrossRef]

1991 (1)

S. Sato, M. Ishigure, and H. Inaba, Electron. Lett. 27, 1831 (1991).
[CrossRef]

Barth, M.

Benson, O.

Benvenuto, A.

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

Besselink, G. A. J.

A. J. Tüdös, G. A. J. Besselink, and R. B. M. Schasfoort, Lab Chip 1, 83 (2001).
[CrossRef]

Block, S. M.

K. Svoboda and S. M. Block, Ann. Rev. Biophys. Biomol. Struct. 23, 247 (1994).
[CrossRef]

Carrozza, M. C.

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

Chen, D.

Cronin-Golomb, M.

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

Dario, P.

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

Domachuk, P.

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

Enger, J.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Eriksson, E.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Goksör, M.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Granéli, A.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Hanstorp, D.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Hoffrén, H. J.

J. Tuominen, H. J. Hoffrén, and H. Ludvigsen, J. Eur. Opt. Soc. Rapid Publ. 2, 07016 (2007).
[CrossRef]

Huang, S. C.

Huang, Y. J.

Inaba, H.

S. Sato, M. Ishigure, and H. Inaba, Electron. Lett. 27, 1831 (1991).
[CrossRef]

Ishigure, M.

S. Sato, M. Ishigure, and H. Inaba, Electron. Lett. 27, 1831 (1991).
[CrossRef]

Lee, C. R.

Li, Y.

Lin, J. D.

Lin, S. H.

Liu, K.-K.

H. Zhang and K.-K. Liu, J. R. Soc. Interface 5, 671 (2008).
[CrossRef]

Ludvigsen, H.

J. Tuominen, H. J. Hoffrén, and H. Ludvigsen, J. Eur. Opt. Soc. Rapid Publ. 2, 07016 (2007).
[CrossRef]

Menciassi, A.

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

Murukeshan, V. M.

V. K. Shinoj and V. M. Murukeshan, J. Appl. Phys. 111, 023106 (2012).
[CrossRef]

V. K. Shinoj and V. M. Murukeshan, Micro Nano Lett. 6, 785 (2011).
[CrossRef]

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

Omenetto, F. G.

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

Padmanabhan, P.

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

Padmanabhan, S.

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

Ramser, K.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Sato, S.

S. Sato, M. Ishigure, and H. Inaba, Electron. Lett. 27, 1831 (1991).
[CrossRef]

Schasfoort, R. B. M.

A. J. Tüdös, G. A. J. Besselink, and R. B. M. Schasfoort, Lab Chip 1, 83 (2001).
[CrossRef]

Scrimgeour, J.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Shinoj, V. K.

V. K. Shinoj and V. M. Murukeshan, J. Appl. Phys. 111, 023106 (2012).
[CrossRef]

V. K. Shinoj and V. M. Murukeshan, Micro Nano Lett. 6, 785 (2011).
[CrossRef]

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

Smolka, S.

Svoboda, K.

K. Svoboda and S. M. Block, Ann. Rev. Biophys. Biomol. Struct. 23, 247 (1994).
[CrossRef]

Tüdös, A. J.

A. J. Tüdös, G. A. J. Besselink, and R. B. M. Schasfoort, Lab Chip 1, 83 (2001).
[CrossRef]

Tuominen, J.

J. Tuominen, H. J. Hoffrén, and H. Ludvigsen, J. Eur. Opt. Soc. Rapid Publ. 2, 07016 (2007).
[CrossRef]

Wellander, R.

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

Wolchover, N.

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

Xie, C.

Yu, C. P.

Zhang, H.

H. Zhang and K.-K. Liu, J. R. Soc. Interface 5, 671 (2008).
[CrossRef]

Ann. Rev. Biophys. Biomol. Struct. (1)

K. Svoboda and S. M. Block, Ann. Rev. Biophys. Biomol. Struct. 23, 247 (1994).
[CrossRef]

Appl. Phys. Lett. (1)

P. Domachuk, N. Wolchover, M. Cronin-Golomb, and F. G. Omenetto, Appl. Phys. Lett. 94, 141101 (2009).
[CrossRef]

Electron. Lett. (1)

S. Sato, M. Ishigure, and H. Inaba, Electron. Lett. 27, 1831 (1991).
[CrossRef]

J. Appl. Phys. (1)

V. K. Shinoj and V. M. Murukeshan, J. Appl. Phys. 111, 023106 (2012).
[CrossRef]

J. Biomed. Opt. (1)

S. Padmanabhan, V. K. Shinoj, V. M. Murukeshan, and P. Padmanabhan, J. Biomed. Opt. 15, 017005 (2010).
[CrossRef]

J. Eur. Opt. Soc. Rapid Publ. (1)

J. Tuominen, H. J. Hoffrén, and H. Ludvigsen, J. Eur. Opt. Soc. Rapid Publ. 2, 07016 (2007).
[CrossRef]

J. Micromech. Microeng. (1)

P. Dario, M. C. Carrozza, A. Benvenuto, and A. Menciassi, J. Micromech. Microeng. 10, 235 (2000).
[CrossRef]

J. Opt. A: Pure Appl. Opt. (1)

E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp, and M. Goksör, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
[CrossRef]

J. R. Soc. Interface (1)

H. Zhang and K.-K. Liu, J. R. Soc. Interface 5, 671 (2008).
[CrossRef]

Lab Chip (1)

A. J. Tüdös, G. A. J. Besselink, and R. B. M. Schasfoort, Lab Chip 1, 83 (2001).
[CrossRef]

Micro Nano Lett. (1)

V. K. Shinoj and V. M. Murukeshan, Micro Nano Lett. 6, 785 (2011).
[CrossRef]

Opt. Express (2)

Opt. Lett. (1)

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Figures (4)

Fig. 1.
Fig. 1.

Schematic of experimental setup employed for the multifunctional trap.

Fig. 2.
Fig. 2.

(a), (b) Images of a particle being trapped within an HC-PCF (solid white lines encircling particle positions are guides for the eyes).

Fig. 3.
Fig. 3.

Optical spectrometer data obtained at the back focal plane of the DO at time intervals of 2 s. In this configuration, an 800 nm laser is used to trap the bead. The 473 nm laser is used as the fluorescence excitation source. Inset: The fluorescence emission region is enlarged.

Fig. 4.
Fig. 4.

(a) Schematic of the setup employing QPD for particle detection, yielding electrical signals proportional to the particle displacements. QPD signals corresponding to the particle positions along the (b) X and (c) Y directions and (d) Brownian motion of the trapped bead projected on the xy plane.

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