Abstract

We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6×106 RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to 18pM concentration of the target biomolecules.

© 2011 Optical Society of America

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