Abstract

We present a portable optical cataract assessment technology which measures with a circular photodetector the fraction of light scattered backwards by the human eye lens when illuminated by a laser diode. As our signal arises directly from the fundamental pathology—increased scattering in the lens—it directly assesses cataract extent and progression. Initial clinical results in undilated human eyes show device reading correlations in agreement with clinical examination and Scheimpflug photography.

© 2011 Optical Society of America

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References

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  1. G. B. Benedek, Invest. Ophthalmol. Visual Sci. 38, 1911(1997).
  2. L. Chylack, in Albert: Albert & Jakobiec’s Principles & Practice of Ophthalmology, 3rd ed, D.M.Albert, J.W.Miller, D.T.Azar, and B.A.Blodi, eds. (Saunders, 2008), ch. 108.
  3. L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).
  4. A. Wegener and H. Laser-Junga, Clin. Experiment. Ophthal. 37, 144 (2009).
    [CrossRef]
  5. M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
    [CrossRef] [PubMed]
  6. M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
    [CrossRef] [PubMed]
  7. D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

2009

A. Wegener and H. Laser-Junga, Clin. Experiment. Ophthal. 37, 144 (2009).
[CrossRef]

D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

2008

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

1997

G. B. Benedek, Invest. Ophthalmol. Visual Sci. 38, 1911(1997).

1993

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

1990

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

Ansari, R.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Bailey, I.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Benedek, G. B.

G. B. Benedek, Invest. Ophthalmol. Visual Sci. 38, 1911(1997).

Brar, G.

D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

Bullimore, M.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Chylack, L.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

L. Chylack, in Albert: Albert & Jakobiec’s Principles & Practice of Ophthalmology, 3rd ed, D.M.Albert, J.W.Miller, D.T.Azar, and B.A.Blodi, eds. (Saunders, 2008), ch. 108.

Clarke, M. P.

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

Datiles, M.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Ferris, F.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Friend, J.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Grewal, D.

D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

Grewal, S.

D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

Laser-Junga, H.

A. Wegener and H. Laser-Junga, Clin. Experiment. Ophthal. 37, 144 (2009).
[CrossRef]

Leske, C.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Matthews, J. C.

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

McCarthy, D.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Pearson, J. C.

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

Reed, G.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Singer, D.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Suh, K.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Vernon, S. A.

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

Vitale, S.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Wegener, A.

A. Wegener and H. Laser-Junga, Clin. Experiment. Ophthal. 37, 144 (2009).
[CrossRef]

Wolfe, J.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Wu, S.-Y.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Zigler, S.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Arch. Ophthalmol.

M. Datiles, R. Ansari, K. Suh, S. Vitale, G. Reed, S. Zigler, and F. Ferris, Arch. Ophthalmol. 126, 1687(2008).
[CrossRef] [PubMed]

Br. J. Ophthalmol.

M. P. Clarke, J. C. Pearson, S. A. Vernon, and J. C. Matthews, Br. J. Ophthalmol. 74, 526 (1990).
[CrossRef] [PubMed]

Clin. Experiment. Ophthal.

A. Wegener and H. Laser-Junga, Clin. Experiment. Ophthal. 37, 144 (2009).
[CrossRef]

Invest. Ophthalmol. Visual Sci.

G. B. Benedek, Invest. Ophthalmol. Visual Sci. 38, 1911(1997).

Ophthalmol. Annu.

D. Grewal, G. Brar, and S. Grewal, Ophthalmol. Annu. 116, 1436 (2009).

The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol.

L. Chylack, J. Wolfe, D. Singer, C. Leske, M. Bullimore, I. Bailey, J. Friend, D. McCarthy, S.-Y. Wu, The Longitudinal Study of Cataract Study Group, Arch. Ophthalmol. 111, 831 (1993).

Other

L. Chylack, in Albert: Albert & Jakobiec’s Principles & Practice of Ophthalmology, 3rd ed, D.M.Albert, J.W.Miller, D.T.Azar, and B.A.Blodi, eds. (Saunders, 2008), ch. 108.

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Figures (4)

Fig. 1
Fig. 1

Phtotograph of cataract measurement device prototype in use.

Fig. 2
Fig. 2

Schematic of cataract measurement device. Arrows represent backscattered laser light.

Fig. 3
Fig. 3

Cataract measuring device reading against clinical rating (LOCS III nuclear opalescence) for 28 human eyes. Pearson correlation coefficient r = 0.59 .

Fig. 4
Fig. 4

Cataract measuring device reading against Pentacam-assessed cataract volume (above threshold of 15% lens density in the Pentacam Nuclear Staging System program) for 24 human eyes. Pearson correlation coefficient r = 0.58 .

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