Abstract

We demonstrate a two-color, fiber-delivered picosecond source for coherent Raman scattering (CRS) imaging. The wavelength-tunable picosecond pump is generated by nonlinear spectral compression of a prechirped femtosecond pulse from a mode-locked titanium:sapphire (Ti:S) laser. The 1064nm picosecond Stokes pulse is generated by an all-fiber time-lens source that is synchronized to the Ti:S laser. The pump and Stokes beams are combined in an optical fiber coupler, which serves not only as the delivery fiber but also as the nonlinear medium for spectral compression of the femtosecond pulse. CRS imaging of mouse skin is performed to demonstrate the practicality of this source.

© 2011 Optical Society of America

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2011

2010

2009

2008

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

2002

1999

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

1993

M. Oberthaler and R. A. Hopfel, Appl. Phys. Lett. 63, 1017 (1993).
[CrossRef]

Andresen, E. R.

Balu, M.

Bégin, S.

Berto, P.

Brackmann, C.

F. Svedberg, C. Brackmann, T. Hellerer, and A. J. Enejder, J. Biomed. Opt. 15, 026026 (2010).
[CrossRef] [PubMed]

Buhman, K. K.

Burgoyne, B.

Chen, H.

Chen, Z.

Cheng, J. X.

Côté, D.

Dong, L.

Dudley, J. M.

Durst, M. E.

Enejder, A. J.

F. Svedberg, C. Brackmann, T. Hellerer, and A. J. Enejder, J. Biomed. Opt. 15, 026026 (2010).
[CrossRef] [PubMed]

Fermann, M. E.

Finot, C.

Freudiger, C. W.

Fu, L.

Fukui, K.

Hanke, T.

He, C.

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Hellerer, T.

F. Svedberg, C. Brackmann, T. Hellerer, and A. J. Enejder, J. Biomed. Opt. 15, 026026 (2010).
[CrossRef] [PubMed]

Holtom, G. R.

K. Kieu, B. G. Saar, G. R. Holtom, X. S. Xie, and F. W. Wise, Opt. Lett. 34, 2051 (2009).
[CrossRef] [PubMed]

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Hopfel, R. A.

M. Oberthaler and R. A. Hopfel, Appl. Phys. Lett. 63, 1017 (1993).
[CrossRef]

Itoh, K.

Johnston, R. S.

Jones, D. J.

Jung, Y.

Kajiyama, S.

Kang, J. X.

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Kieu, K.

Kitagawa, Y.

Kobat, D.

Krauss, G.

Lee, J. H.

Leitenstorfer, A.

Liu, G.

Lu, S.

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Mercier, V.

Min, W.

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Moffatt, D. J.

Nishimura, N.

Nishizawa, N.

Oberthaler, M.

M. Oberthaler and R. A. Hopfel, Appl. Phys. Lett. 63, 1017 (1993).
[CrossRef]

Oron, D.

Ozeki, Y.

Pegoraro, A. F.

Pezacki, J. P.

Potma, E. O.

Ridsdale, A.

Rigneault, H.

Saar, B. G.

Schaffer, C. B.

Seibel, E. J.

Sell, A.

Selm, R.

Shi, Y.

Slipchenko, M. N.

Stolow, A.

Sumimura, K.

Svedberg, F.

F. Svedberg, C. Brackmann, T. Hellerer, and A. J. Enejder, J. Biomed. Opt. 15, 026026 (2010).
[CrossRef] [PubMed]

Thomas, B. K.

Träutlein, D.

Tromberg, B. J.

Tsai, J. C.

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Umemura, W.

Vallée, R.

Villeneuve, A.

Wang, H.

Wang, K.

Winterhalder, M.

Wise, F. W.

Wong, A. W.

Xie, X. S.

Xu, C.

Ye, J.

Zhu, J.

Zumbusch, A.

Appl. Phys. Lett.

M. Oberthaler and R. A. Hopfel, Appl. Phys. Lett. 63, 1017 (1993).
[CrossRef]

Biomed. Opt. Express

J. Biomed. Opt.

F. Svedberg, C. Brackmann, T. Hellerer, and A. J. Enejder, J. Biomed. Opt. 15, 026026 (2010).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Rev. Lett.

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Science

C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

Experimental setup of the fiber-delivered two-color picosecond source for CARS imaging. The 1064 nm synchronized time-lens source is described in detail in [12]: M, mirror; G, 1800   line / mm grating; L1, f = 30 cm concave lens; CL, f = 10 m concave cylindrical lens; BS, beam splitter; HWP, half-wave plate; QWP, quarter-wave plate; L2, aspheric lens; CFBG, chirped fiber Bragg grating; L3, collimating lens; LPF, 800 nm long-pass filter; PC, polarization controller.

Fig. 2
Fig. 2

(a) Measured (dots) and calculated (curve) pulse width as a function of the rotation angle of the cylindrical lens. (b) Measured 817 nm pump pulse spectra at various output power from the fiber coupler. (c) Measured second-order interferometric autocorrelation trace at 150 mW output power.

Fig. 3
Fig. 3

(a) Measured spectrum of the time-lens output. Cross-correlation traces of the time-lens output with an 87 fs pulse (b) and the 150 mW , 1.8 ps pulse from the fiber coupler (c). (c) Inset, measured SF signal at the half-maximum of the cross-correlation trace over 180 s .

Fig. 4
Fig. 4

CARS image of sebaceous glands at the CH 2 stretching frequency in mouse ear: 512 × 512 pixels, 4 s / frame , no average.

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