Abstract

Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.

© 2011 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Optoacoustic tomography with varying illumination and non-uniform detection patterns

Thomas Jetzfellner, Amir Rosenthal, Andreas Buehler, Alexander Dima, Karl-Hans Englmeier, Vasilis Ntziachristos, and Daniel Razansky
J. Opt. Soc. Am. A 27(11) 2488-2495 (2010)

Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging

Rui Ma, Adrian Taruttis, Vasilis Ntziachristos, and Daniel Razansky
Opt. Express 17(24) 21414-21426 (2009)

Video rate optoacoustic tomography of mouse kidney perfusion

Andreas Buehler, Eva Herzog, Daniel Razansky, and Vasilis Ntziachristos
Opt. Lett. 35(14) 2475-2477 (2010)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (3)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription