An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrast- enhanced PA imaging at a wavelength of . Of all the wavelengths tested in a range from 710 to , the background PA signal from tissue in vivo was lowest and more homogeneous at . For blood-laden tissue, the background PA signal was up to 70% less at . Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at increased 38% compared to . Therefore, contrast-enhanced PA imaging at is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.
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