Abstract

Optoacoustic tomography can visualize optical contrast in tissues while capitalizing on the advantages of ultrasound, such as high spatial resolution and fast imaging capabilities. We report a novel multispectral optoacoustic tomography system for deep tissue small animal imaging. The previously undocumented capacity of whole-body optoacoustic tomography at a video rate has been demonstrated by visualizing mouse kidney perfusion using Indocyanine Green in vivo.

© 2010 Optical Society of America

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  1. V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
    [CrossRef]
  2. L. V. Wang, Med. Phys. 35, 5758 (2008).
    [CrossRef]
  3. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
    [CrossRef]
  4. D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
    [CrossRef]
  5. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, Opt. Express 17, 21414 (2009).
    [CrossRef]
  6. X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
    [CrossRef]
  7. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
    [CrossRef]
  8. B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
    [CrossRef]
  9. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
    [CrossRef]
  10. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
    [CrossRef]
  11. C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
    [CrossRef]
  12. B. A. J. Angelsen, Ultrasound Imaging (Emantec AS, 2000).
  13. A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
    [CrossRef]
  14. M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

2010 (1)

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

2009 (6)

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
[CrossRef]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, Opt. Express 17, 21414 (2009).
[CrossRef]

2008 (1)

L. V. Wang, Med. Phys. 35, 5758 (2008).
[CrossRef]

2007 (1)

2005 (1)

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

2004 (1)

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

2003 (1)

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

1976 (1)

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Aguirre, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

Angelsen, B. A. J.

B. A. J. Angelsen, Ultrasound Imaging (Emantec AS, 2000).

Brecht, H. P.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

Chen, Q.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Conjusteau, A.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Distel, M.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

Fronheiser, M.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

Gamelin, J.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

Guo, P. Y.

Huang, F.

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Koster, R. W.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

Ku, G.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Kwant, G.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Landsman, M. L. J.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Li, C.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

Ma, R.

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, Opt. Express 17, 21414 (2009).
[CrossRef]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

Maurudis, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

Mook, G. A.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

Ntziachristos, V.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
[CrossRef]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, Opt. Express 17, 21414 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
[CrossRef]

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

Pang, Y. J.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Perrimon, N.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

Razansky, D.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
[CrossRef]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, Opt. Express 17, 21414 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
[CrossRef]

Ripoll, J.

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

Rosenthal, A.

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
[CrossRef]

Stoica, G.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Su, R.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

Tan, Y.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Taruttis, A.

Vinegoni, C.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
[CrossRef]

Wang, L. H. V.

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Wang, L. V.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

L. V. Wang, Med. Phys. 35, 5758 (2008).
[CrossRef]

Wang, X. D.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Wang, Y.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Weissleder, R.

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

Xie, X. Y.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Xing, D.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Yin, B. Z.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Zeng, Y. G.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Zhu, Q.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, Opt. Express 17, 10489 (2009).
[CrossRef]

Zijlstra, W. G.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

IEEE Trans. Med. Imaging (1)

A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 28, 1997 (2009).
[CrossRef]

J. Appl. Physiol. (1)

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, J. Appl. Physiol. 40, 575 (1976).

J. Biomed. Opt. (2)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, J. Biomed. Opt. 14, 064007 (2009).
[CrossRef]

J. Biomed. Opt. Lett. (1)

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, J. Biomed. Opt. Lett. 15, 010509 (2010).
[CrossRef]

Med. Phys. (1)

L. V. Wang, Med. Phys. 35, 5758 (2008).
[CrossRef]

Nat. Biotech. (2)

V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, Nat. Biotech. 23, 313 (2005).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. V. Wang, Nat. Biotech. 21, 803 (2003).
[CrossRef]

Nat. Photon. (1)

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, Nat. Photon. 3, 412(2009).
[CrossRef]

Opt. Express (2)

Opt. Lett. (1)

Phys. Med. Biol. (1)

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. G. Zeng, Y. Tan, and Q. Chen, Phys. Med. Biol. 49, 1339 (2004).
[CrossRef]

Other (1)

B. A. J. Angelsen, Ultrasound Imaging (Emantec AS, 2000).

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