Abstract

We developed and fabricated a preclinical photoacoustic imaging endoscope (PAIE) with an acousto-optic coaxial structure for cavity imaging that integrates a Plexiglas tube, an optical fiber, a ring transducer array, a taper reflector, and an ultrasonic coupling medium. A photoacoustic image for a section of pig colorectal tissue embedded in a transparent gelatin phantom was reconstructed. Furthermore, human colorectal cancer and normal colorectal tissue were imaged ex vivo with a contrast ratio of ~2.3. Experimental results demonstrate that the PAIE has potential for detecting colorectal cancer in clinical use.

© 2010 Optical Society of America

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