Abstract

A technique to enhance the photoacoustic emissions from laser-heated nanoparticles is presented. Gold nano particle-doped phantoms are subjected to pulsed optical and ultrasound fields, resulting in bubble formation and collapse and producing strong acoustic emissions. The applied ultrasound field allows for cavitation at lower laser fluences than using light alone. The acoustic emission associated with bubble collapse well exceeds the direct photoacoustic response and is used to image a nanoparticle-doped region in a tissue phantom. The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.

© 2010 Optical Society of America

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2009

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

D. Lapotko, Opt. Express 17, 2538 (2009).
[CrossRef] [PubMed]

2008

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

2007

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

B. Krasovitski, H. Kislev, and E. Kimmel, Ultrasonics 47, 90 (2007).
[CrossRef] [PubMed]

2006

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

2005

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

M. Ferrari, Nat. Rev. Cancer 5, 161 (2005).
[CrossRef] [PubMed]

2004

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

2003

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

V. P. Zharov, V. Galitovsky, and M. Viegas, Appl. Phys. Lett. 83, 4897 (2003).
[CrossRef]

2001

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateena, Proc. SPIE 4434, 60 (2001).
[CrossRef]

1994

T. G. Leighton, The Acoustic Bubble (Academic, 1994).

Anderson, R. R.

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Conjusteau, A.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Copland, J. A.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Eghtadri, M.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

El-Sayed, I. H.

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

El-Sayed, M. A.

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

Farny, C. H.

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

Ferrari, M.

M. Ferrari, Nat. Rev. Cancer 5, 161 (2005).
[CrossRef] [PubMed]

Galanzha, E. I.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

Galitovskaya, E. N.

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

Galitovsky, V.

V. P. Zharov, V. Galitovsky, and M. Viegas, Appl. Phys. Lett. 83, 4897 (2003).
[CrossRef]

Gill, K. L.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Holt, R. G.

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

Huang, X.

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

Jain, P. K.

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

Joe, E. K.

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Karabutov, A. A.

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateena, Proc. SPIE 4434, 60 (2001).
[CrossRef]

Kim, J-W.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

Kimmel, E.

B. Krasovitski, H. Kislev, and E. Kimmel, Ultrasonics 47, 90 (2007).
[CrossRef] [PubMed]

Kislev, H.

B. Krasovitski, H. Kislev, and E. Kimmel, Ultrasonics 47, 90 (2007).
[CrossRef] [PubMed]

Kotagiri, N.

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

Kotov, N. A.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Krasovitski, B.

B. Krasovitski, H. Kislev, and E. Kimmel, Ultrasonics 47, 90 (2007).
[CrossRef] [PubMed]

Ku, G.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Lapotko, D.

Leighton, T. G.

T. G. Leighton, The Acoustic Bubble (Academic, 1994).

Li, Z.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Lin, C. P.

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Mercer, K. E.

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

Moon, H-M.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

Motamedi, M.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Murray, T. W.

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

O’Neal, D. P.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Oraevsky, A.

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Oraevsky, A. A.

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateena, Proc. SPIE 4434, 60 (2001).
[CrossRef]

Pitsillides, C. M.

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Roy, R. A.

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

Savateena, E. V.

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateena, Proc. SPIE 4434, 60 (2001).
[CrossRef]

Shashkov, E. V.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

Skrabalak, S. E.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Smeltzer, M. S.

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

Stoica, G.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Viegas, M.

V. P. Zharov, V. Galitovsky, and M. Viegas, Appl. Phys. Lett. 83, 4897 (2003).
[CrossRef]

Wang, L. V.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Wang, X.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Wang, Y.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Wei, X.

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Wu, T.

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

Xia, Y.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Xie, X.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

Yang, X. M.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Zharov, V. P.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

V. P. Zharov, V. Galitovsky, and M. Viegas, Appl. Phys. Lett. 83, 4897 (2003).
[CrossRef]

Acoust. Res. Lett. Online

C. H. Farny, T. Wu, R. G. Holt, T. W. Murray, and R. A. Roy, Acoust. Res. Lett. Online 6, 138 (2005).
[CrossRef]

Appl. Phys. Lett.

V. P. Zharov, V. Galitovsky, and M. Viegas, Appl. Phys. Lett. 83, 4897 (2003).
[CrossRef]

Biophys. J.

V. P. Zharov, K. E. Mercer, E. N. Galitovskaya, and M. S. Smeltzer, Biophys. J. 90, 619 (2006).
[CrossRef]

C. M. Pitsillides, E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin, Biophys. J. 84, 4023 (2003).
[CrossRef] [PubMed]

Lasers Med. Sci.

X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci. 23, 217 (2008).
[CrossRef]

Lasers Surg. Med.

J-W. Kim, E. V. Shashkov, E. I. Galanzha, N. Kotagiri, and V. P. Zharov, Lasers Surg. Med. 39, 622 (2007).
[CrossRef] [PubMed]

Nano Lett.

X. M. Yang, S. E. Skrabalak, Z. Li, Y. Xia, and L. V. Wang, Nano Lett. 7, 3798 (2007).
[CrossRef] [PubMed]

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O’Neal, G. Stoica, and L. V. Wang, Nano Lett. 4, 1689 (2004).
[CrossRef]

M. Eghtadri, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, Nano Lett. 7, 1914 (2007).
[CrossRef]

Nat. Nano.

J-W. Kim, E. I. Galanzha, E. V. Shashkov, H-M. Moon, and V. P. Zharov, Nat. Nano. 4, 688 (2009).
[CrossRef]

Nat. Rev. Cancer

M. Ferrari, Nat. Rev. Cancer 5, 161 (2005).
[CrossRef] [PubMed]

Opt. Express

Proc. SPIE

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateena, Proc. SPIE 4434, 60 (2001).
[CrossRef]

Ultrasonics

B. Krasovitski, H. Kislev, and E. Kimmel, Ultrasonics 47, 90 (2007).
[CrossRef] [PubMed]

Other

T. G. Leighton, The Acoustic Bubble (Academic, 1994).

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Figures (3)

Fig. 1
Fig. 1

Experimental setup. The following abbreviations are used: IMB, impedance matching box; FLS, flashlamp sync; PBS, polarizing beamsplitter; and PD, photodetector.

Fig. 2
Fig. 2

(a) Single-shot (top) and aver aged ( 500 × ) photoacoustic signals generated at a fluence of 11.4 mJ / cm 2 . (b) Single-shot inertial collapse signals generated at the same fluence as (a) but with 1.0 and 1.5 MPa ultrasound fields. (c) Peak amplitudes of inertial collapse signals and photoacoustic (PA) signals generated as a function of laser fluence. The inset shows the probability of detecting an inertial collapse event.

Fig. 3
Fig. 3

Images of nanoparticle-doped spheres generated from the photoacoustic response to a laser fluence of (a) 22.6 mJ / cm 2 and (b) 11.4 mJ / cm 2 . Images created using the inertial collapse signals with an applied 1.5 MPa ultrasound field are shown in (c) for a laser fluence of 22.6 mJ / cm 2 and (d) 11.4 mJ / cm 2 . The sphere diameters were (a), (c) 530 μm and (b), (d) 550 μm .

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