Abstract

Computationally reconstructed interferometric synthetic aperture microscopy is coregistered with optical coherence tomography (OCT) focal plane data to provide quantitative cross validation with OCT. This is accomplished through a qualitative comparison of images and a quantitative analysis of the width of the point-spread function in simulation and experiment. The width of the ISAM point-spread function is seen to be independent of depth, in contrast to OCT.

© 2010 Optical Society of America

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2007 (3)

2006 (4)

2004 (1)

2003 (1)

2002 (1)

1999 (1)

1998 (1)

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

1997 (1)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Artal, P.

Bachmann, A. H.

Boppart, S. A.

Bouma, B. E.

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Brezinski, M. E.

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Carney, P. S.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Chen, Z.

Davis, B. J.

Ding, Z.

Drexler, W.

Fercher, A. F.

Fernández, E. J.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

W. Drexler, U. Morgner, F. X. Krtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 24, 1221 (1999).
[CrossRef]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hee, R.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hermann, B.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Ippen, E. P.

Krtner, F. X.

Lasser, T.

Leitgeb, R. A.

Li, X. D.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Marks, D. L.

Menard, S. W.

S. W. Menard, Applied Logistic Regression Analysis (Sage, 2002).

Morgner, U.

Nelson, J. S.

Oldenburg, A. L.

Pitris, C.

W. Drexler, U. Morgner, F. X. Krtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 24, 1221 (1999).
[CrossRef]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Prieto, P. M.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Ralston, T. S.

Ren, H.

Reynolds, J. J.

Sattmann, H.

Schlachter, S. C.

Southern, J. F.

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Steinmann, L.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Unterhuber, A.

Villiger, M.

Zhao, Y.

Appl. Opt. (1)

J. Opt. Soc. Am. A (4)

Nat. Phys. (1)

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

Opt. Lett. (5)

Radiology (1)

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, Radiology 208, 81 (1998).
[PubMed]

Science (2)

D. Huang, E. A. Swanson, C. P. Lin, W. G. Stinson, W. Chang, R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
[CrossRef] [PubMed]

Other (2)

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, in IEEE International Symposium on Biomedical Imaging, IEEE (2006), pp. 578–581.
[CrossRef]

S. W. Menard, Applied Logistic Regression Analysis (Sage, 2002).

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Figures (4)

Fig. 1
Fig. 1

(a) En face OCT of a plane 450 μ m above the focal plane. (b) ISAM reconstruction of the same en face plane. (c) En face OCT with the focal plane moved to the plane of interest in (a). The field of view in each panel is 360 μ m × 360 μ m . All images are displayed on a linear scale. The gray scales indicate the displayed range of relative signal amplitudes.

Fig. 2
Fig. 2

Simulation of scatterers in OCT and ISAM. The plot shows the PSF (FWHM) versus distance from focus for simulated OCT (solid curve), simulated ISAM (dashed curve), and the corresponding theoretical PSF of OCT (crosshair curve).

Fig. 3
Fig. 3

Experimental measurement of the PSF (FWHM) versus distance from the focus for OCT (solid curve) and ISAM (dashed curve).

Fig. 4
Fig. 4

ISAM and OCT in ex vivo rat adipose tissue. (a) En face OCT of a plane 419 μ m (optical depth) above the focal plane. (b) ISAM reconstruction of the same en face plane. (c) En face OCT with the focal plane moved to the plane of interest in (a). The field of view in each panel is 500 μ m × 500 μ m . All images have gamma correction ( γ = 0.5 ) . Gray scales indicate the displayed range of relative signal amplitudes.

Equations (1)

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S ̃ ( Q , k ) = K ( Q , k ) η ͌ [ Q , 2 k 2 Q 2 4 ] ,

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