Abstract

Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from 3% to 4%. Spectral analysis was also performed on the acquired data, which improved the processing speed by a factor of 5 compared with a least-square fitting approach. Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties.

© 2009 Optical Society of America

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2009 (1)

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

2008 (4)

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, Opt. Express 16, 11525 (2008).
[PubMed]

X. Liang, A. L. Oldenburg, V. Crecea, E. J. Chaney, and S. A. Boppart, Opt. Express 16, 11052 (2008).
[CrossRef] [PubMed]

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

2006 (2)

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

2005 (3)

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

2002 (1)

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

2001 (1)

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

2000 (1)

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

1998 (1)

Ahn, Y.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Boppart, S. A.

Bouma, B. E.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

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B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Catheline, S.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Chadwick, R. S.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Chan, R. C.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Chaney, E. J.

Chau, A. H.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Chen, Z.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Chiang, H. K.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Crecea, V.

Dadd, M. J.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Dimitriadis, E. K.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Dumont, D. M.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Fahey, B. J.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Fink, M.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Greenleaf, J. F.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Horkay, F.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Hsu, S. J.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Huang, S.

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

Ingber, D. E.

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

Insana, M. F.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Jia, W.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Kaazempur, M. M. R.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Kachar, B.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Khalil, A. S.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Kim, C.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Kinnick, R. R.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Ko, H.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Kuhl, C.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Liang, X.

Lorenzen, J.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Maresca, J.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Nelson, R. C.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Nightingale, K. R.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Nightingale, R. W.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Oldenburg, A. L.

Orescanin, M.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Palmeri, M. L.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Rao, B.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Rinne, S. A.

Robinson, D. E.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Schmitt, J. M.

Sinkus, R.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Sondermann, E.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Stack, R.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Tan, W.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Tanter, M.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Toohey, K. S.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Trahey, G. E.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Urban, M. W.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Wang, L. V.

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Wang, Q.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Wilson, L. S.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Xu, M.

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Yu, L.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Ann. Biomed. Eng. (1)

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Biophys. J. (1)

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Cancer Cells (1)

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

J. Acoust. Soc. Am. (2)

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Magn. Reson. Med. (1)

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Opt. Express (3)

Phys. Med. Biol. (2)

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Proc. SPIE (1)

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Tissue Eng. (1)

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Other (1)

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

(a) OCE classifications. (b) Schematic diagram of AM-OCE.

Fig. 2
Fig. 2

AM-OCE data analysis. (a) B-mode (brightness mode) OCT image of a sphere embedded in tissue phantom. (b) Amplitude of the M-mode OCT image of the sphere recorded at the position shown by the arrow in (a). (c) Phase of the M-mode OCT image and its fitting curve in the time domain. (d) Power spectrum of (c).

Fig. 3
Fig. 3

AM-OCE results on gelatin phantoms. (a) AM-OCE shear modulus. (b) AM-OCE shear damping parameter. * denotes no statistical or calculation error estimations.

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