Abstract

Experimental evidence supporting the use of a surface-plasmon interferometer as a biosensor is presented. The device is shown to be capable of bulk refractive index sensing (bulk refractometry) and has a spectral interrogation sensitivity of 315.145nm/refractive index unit.

© 2009 Optical Society of America

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References

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  1. W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
    [CrossRef]
  2. K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, Opt. Express 15, 7610 (2007).
    [CrossRef] [PubMed]
  3. R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.
  4. X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
    [CrossRef] [PubMed]
  5. J. Homola, Anal. Bioanal. Chem. 377, 528 (2003).
    [CrossRef] [PubMed]
  6. P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, Opt. Express 14, 7063 (2006).
    [CrossRef] [PubMed]
  7. S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
    [CrossRef]
  8. D. R. Lide, CRC Handbook of Chemistry and Physics (CRC Press, 2004).
  9. S. Hiu and X. G. Huang, Sens. Actuators B 126, 579 (2007).
    [CrossRef]
  10. C. Thirstrup and W. Zong, Sens. Actuators B 106, 796 (2005).
    [CrossRef]
  11. P. Debackere, P. Bienstman, and R. Baets, Opt. Quantum Electron. 38, 857 (2006).
    [CrossRef]
  12. J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
    [CrossRef]

2009 (1)

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

2007 (4)

K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, Opt. Express 15, 7610 (2007).
[CrossRef] [PubMed]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
[CrossRef] [PubMed]

S. Hiu and X. G. Huang, Sens. Actuators B 126, 579 (2007).
[CrossRef]

2006 (2)

P. Debackere, P. Bienstman, and R. Baets, Opt. Quantum Electron. 38, 857 (2006).
[CrossRef]

P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, Opt. Express 14, 7063 (2006).
[CrossRef] [PubMed]

2005 (2)

2004 (1)

D. R. Lide, CRC Handbook of Chemistry and Physics (CRC Press, 2004).

2003 (1)

J. Homola, Anal. Bioanal. Chem. 377, 528 (2003).
[CrossRef] [PubMed]

1997 (1)

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

Baets, R.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, Opt. Express 15, 7610 (2007).
[CrossRef] [PubMed]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, Opt. Express 14, 7063 (2006).
[CrossRef] [PubMed]

P. Debackere, P. Bienstman, and R. Baets, Opt. Quantum Electron. 38, 857 (2006).
[CrossRef]

W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
[CrossRef]

Bartolozzi, I.

Beckx, S.

Bienstman, P.

Bogaerts, W.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
[CrossRef]

Ctyrocký, J.

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

De Vos, K.

K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, Opt. Express 15, 7610 (2007).
[CrossRef] [PubMed]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

Debackere, P.

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, Opt. Express 14, 7063 (2006).
[CrossRef] [PubMed]

P. Debackere, P. Bienstman, and R. Baets, Opt. Quantum Electron. 38, 857 (2006).
[CrossRef]

Dumon, P.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
[CrossRef]

Hiu, S.

S. Hiu and X. G. Huang, Sens. Actuators B 126, 579 (2007).
[CrossRef]

Hoa, X. D.

X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
[CrossRef] [PubMed]

Homola, J.

J. Homola, Anal. Bioanal. Chem. 377, 528 (2003).
[CrossRef] [PubMed]

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

Hradilová, J.

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

Huang, X. G.

S. Hiu and X. G. Huang, Sens. Actuators B 126, 579 (2007).
[CrossRef]

Kirk, A. G.

X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
[CrossRef] [PubMed]

Kolárová, P.

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

Lide, D. R.

D. R. Lide, CRC Handbook of Chemistry and Physics (CRC Press, 2004).

Luyssaert, B.

Schacht, E.

Schaekers, M.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

Scheerlinck, S.

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, Opt. Express 14, 7063 (2006).
[CrossRef] [PubMed]

Selvaraja, S.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

Skalský, M.

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

Sleeckx, E.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

Tabrizian, M.

X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
[CrossRef] [PubMed]

Taillaert, D.

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
[CrossRef]

Thirstrup, C.

C. Thirstrup and W. Zong, Sens. Actuators B 106, 796 (2005).
[CrossRef]

Van Campenhout, J.

Van Thourhout, D.

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, J. Lightwave Technol. 23, 401 (2005).
[CrossRef]

Wiaux, V.

Zong, W.

C. Thirstrup and W. Zong, Sens. Actuators B 106, 796 (2005).
[CrossRef]

Anal. Bioanal. Chem. (1)

J. Homola, Anal. Bioanal. Chem. 377, 528 (2003).
[CrossRef] [PubMed]

Biosens. Bioelectron. (1)

X. D. Hoa, A. G. Kirk, and M. Tabrizian, Biosens. Bioelectron. 23, 151 (2007).
[CrossRef] [PubMed]

J. Lightwave Technol. (1)

Opt. Commun. (1)

S. Selvaraja, E. Sleeckx, M. Schaekers, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. Baets, Opt. Commun. 182, 1767 (2009).
[CrossRef]

Opt. Express (2)

Opt. Quantum Electron. (1)

P. Debackere, P. Bienstman, and R. Baets, Opt. Quantum Electron. 38, 857 (2006).
[CrossRef]

Sens. Actuators B (3)

J. Homola, J. Čtyrocký, M. Skalský, J. Hradilová, and P. Kolářová, Sens. Actuators B 38-39, 286 (1997).
[CrossRef]

S. Hiu and X. G. Huang, Sens. Actuators B 126, 579 (2007).
[CrossRef]

C. Thirstrup and W. Zong, Sens. Actuators B 106, 796 (2005).
[CrossRef]

Other (2)

D. R. Lide, CRC Handbook of Chemistry and Physics (CRC Press, 2004).

R. Baets, D. Taillaert, W. Bogaerts, P. Dumon, K. De Vos, P. Debackere, S. Scheerlinck, and D. Van Thourhout, in Conference on Lasers and Electro-Optics (Optical Society of America, 2007), pp. 1221-1222.

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Figures (5)

Fig. 1
Fig. 1

Schematical setup of the proposed structure, | E x | field shown (perpendicular to the interface).

Fig. 2
Fig. 2

Left, schematic representation of the surface-plasmon interferometer, the flowcell, and the measurement setup; right, focused ion beam cross section of the fabricated device.

Fig. 3
Fig. 3

Simulated transmission spectra for H 2 O , 2 m. % NaCl, and 10 m. % Nacl. Simulations done using CAMFR, an in-house developed eigenmode solver using adaptive spatial resolution [11]. Theoretical sensitivity is equal to 392 nm /RIU.

Fig. 4
Fig. 4

Measured transmission spectra for H 2 O , 2 m. % NaCl, and 10 m. % Nacl, fiber-to-detector spectra.

Fig. 5
Fig. 5

λ min as a function of NaCl concentration; the solid line is a linear fit to calculated λ min values.

Tables (1)

Tables Icon

Table 1 λ min , δ λ min , and Detection Limit (DL) as a Function of NaCl Concentration a

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