Abstract

We present a compact coherent anti-Stokes Raman scattering microscope based on a widely tunable picosecond Er:fiber laser. Intense and bandwidth-limited 1 ps pump pulses at a center wavelength of 775 nm are generated via frequency mixing within the broadband fundamental at 1.55 μm. Narrowband Stokes pulses are obtained by frequency shifting of solitons in a highly nonlinear bulk fiber and subsequent second-harmonic generation. The tuning range from 850 nm to 1100 nm gives access to vibrational resonances between 1150cm1 and 3800cm1. A first imaging application in the spectral region of CH stretch vibrations is demonstrated.

© 2009 Optical Society of America

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2009 (2)

2008 (1)

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883909 (2008).
[CrossRef]

2007 (3)

2006 (3)

2005 (2)

A. Volkmer, J. Phys. D 38, R59 (2005).
[CrossRef]

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

2004 (1)

2003 (2)

2002 (1)

2000 (2)

M. Hashimoto, T. Araki, and S. Kawata, Opt. Lett. 25, 1768 (2000).
[CrossRef]

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

1999 (1)

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

1993 (1)

1991 (1)

1971 (1)

D. von der Linde, A. Laubereau, and W. Kaiser, Phys. Rev. Lett. 26, 954 (1971).
[CrossRef]

Adler, F.

Andresen, E. R.

Araki, T.

Arbore, M. A.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Birkedal, V.

Brackmann, C.

Burkacky, O.

Cheng, J.-X.

Coté, D.

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Enejder, A.

Evans, C. L.

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883909 (2008).
[CrossRef]

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Fejer, M. M.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Fermann, M.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Galvanauskas, A.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Harter, D.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Hashimoto, M.

Haus, H. A.

Hilligsøe, K. M.

Holtom, G. R.

Huber, R.

Imeshev, G.

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

Ippen, E. P.

Ishigame, Y.

Jones, D. J.

Kaiser, W.

D. von der Linde, A. Laubereau, and W. Kaiser, Phys. Rev. Lett. 26, 954 (1971).
[CrossRef]

Kawata, S.

Keiding, S. R.

Kieu, K.

Krauss, G.

Larsen, J.

Laubereau, A.

D. von der Linde, A. Laubereau, and W. Kaiser, Phys. Rev. Lett. 26, 954 (1971).
[CrossRef]

Leitenstorfer, A.

Lin, C. P.

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Moutzouris, K.

Müller, M.

M. Müller and A. Zumbusch, ChemPhysChem 8, 2156 (2007).
[CrossRef] [PubMed]

Nelson, L. E.

Nielsen, C. K.

Nishihara, H.

Paulsen, H. N.

Potma, E. O.

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

E. O. Potma, D. J. Jones, J.-X. Cheng, X. S. Xie, and J. Ye, Opt. Lett. 27, 1168 (2002).
[CrossRef]

Puoris'haag, M.

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Saar, B. G.

Scheu, R.

Sell, A.

Sotier, F.

Suhara, T.

Tamura, K.

Tauser, F.

Thøgersen, J.

Träutlein, D.

Volkmer, A.

A. Volkmer, J. Phys. D 38, R59 (2005).
[CrossRef]

von der Linde, D.

D. von der Linde, A. Laubereau, and W. Kaiser, Phys. Rev. Lett. 26, 954 (1971).
[CrossRef]

Wise, F. W.

Xie, X. S.

K. Kieu, B. G. Saar, G. R. Holtom, X. S. Xie, and F. W. Wise, Opt. Lett. 34, 2051 (2009).
[CrossRef] [PubMed]

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883909 (2008).
[CrossRef]

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

E. O. Potma, D. J. Jones, J.-X. Cheng, X. S. Xie, and J. Ye, Opt. Lett. 27, 1168 (2002).
[CrossRef]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Ye, J.

Zinth, W.

Zumbusch, A.

M. Müller and A. Zumbusch, ChemPhysChem 8, 2156 (2007).
[CrossRef] [PubMed]

O. Burkacky, A. Zumbusch, C. Brackmann, and A. Enejder, Opt. Lett. 31, 3656 (2006).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Annu. Rev. Anal. Chem. (1)

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883909 (2008).
[CrossRef]

ChemPhysChem (1)

M. Müller and A. Zumbusch, ChemPhysChem 8, 2156 (2007).
[CrossRef] [PubMed]

J. Opt. Soc. Am. B (1)

G. Imeshev, M. A. Arbore, M. M. Fejer, A. Galvanauskas, M. Fermann, and D. Harter, J. Opt. Soc. Am. B 17, 1148 (2000).

J. Phys. D (1)

A. Volkmer, J. Phys. D 38, R59 (2005).
[CrossRef]

Opt. Express (3)

Opt. Lett. (11)

Phys. Rev. Lett. (2)

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

D. von der Linde, A. Laubereau, and W. Kaiser, Phys. Rev. Lett. 26, 954 (1971).
[CrossRef]

Proc. Natl. Acad. Sci. USA (1)

C. L. Evans, E. O. Potma, M. Puoris'haag, D. Coté, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

Schematic setup of the laser system. OSC, fs-Er:fiber oscillator; EDFA, erbium-doped fiber amplifier; Si PC, silicon prism compressor; HNF, highly nonlinear germanosilicate fiber for frequency conversion; Ge, 50-μm-thick germanium plate for dispersion management (optional); PPLN, periodically poled lithium niobate crystal; VDL, variable delay line; DBC, dichroic beam combiner.

Fig. 2
Fig. 2

Spectral intensity of the picosecond pump pulses versus wavelength (a) and nonlinear autocorrelation trace (b).

Fig. 3
Fig. 3

Spectral power of the tunable Stokes pulses versus wavelength. The spectra from 960 nm to 1100 nm are generated using a 50-μm-thin Ge Brewster plate for dispersion management before frequency doubling. Average output powers at various wavelength positions are indicated.

Fig. 4
Fig. 4

(a) and (b) Microscopic CARS image of a mixture of PS and PMMA beads on a glass slide. (a) Imaging of the aliphatic CH stretch vibration resonance at 2950 cm 1 and (b) the aromatic CH stretch vibration at 3050 cm 1 . (c) Imaging of the lipid distribution in live C. elegans at 2845 cm 1 .

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