Abstract

By detecting the transient four-wave mixing from gold nanoparticles in resonance with their surface plasmon, we demonstrate a multiphoton imaging modality suited for cell microscopy. Four-wave mixing is measured free from background using a three-beam excitation geometry and heterodyne detection. We achieve a spatial resolution of 140 nm in-plane and 470 nm in the axial direction, surpassing the one-photon diffraction limit. With this technique, high-contrast photostable imaging of Golgi structures is demonstrated in HepG2 cells labeled with gold nanoparticles of 10 nm and 5 nm diameter.

© 2009 Optical Society of America

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  1. H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
    [CrossRef]
  2. D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
    [CrossRef]
  3. M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
    [CrossRef]
  4. D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007), and references therein.
    [CrossRef]
  5. P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
    [CrossRef]
  6. P. Borri and W. Langbein, J. Phys. Condens. Matter 19, 295201 (2007).
    [CrossRef]
  7. F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
    [CrossRef]
  8. F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
    [CrossRef]

2009

F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
[CrossRef]

2008

F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
[CrossRef]

2007

2006

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

2005

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

2002

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

2001

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Berciaud, S.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Bimberg, D.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Blab, G. A.

Borri, P.

F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
[CrossRef]

F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
[CrossRef]

P. Borri and W. Langbein, J. Phys. Condens. Matter 19, 295201 (2007).
[CrossRef]

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Boyer, D.

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

Cheng, J.-X.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Cognet, L.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007), and references therein.
[CrossRef]

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Giorgi, F. D.

He, W.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Huff, T. B.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Ichas, F.

Langbein, W.

F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
[CrossRef]

F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
[CrossRef]

P. Borri and W. Langbein, J. Phys. Condens. Matter 19, 295201 (2007).
[CrossRef]

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Lasne, D.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007), and references therein.
[CrossRef]

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Lippitz, M.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Lounis, B.

D. Lasne, G. A. Blab, F. D. Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express 15, 14184 (2007), and references therein.
[CrossRef]

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

Low, P. S.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Maali, A.

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

Masia, F.

F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
[CrossRef]

F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
[CrossRef]

Orrit, M.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

Ouyang, D.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Schneider, S.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Sellin, R. L.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Tamarat, P.

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

Tchebotareva, A. L.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

van Dijk, M. A.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Wang, H.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Wei, A.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Woggon, U.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Zweifel, D. A.

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Appl. Phys. Lett.

F. Masia, W. Langbein, and P. Borri, Appl. Phys. Lett. 93, 021114 (2008).
[CrossRef]

J. Phys. Condens. Matter

P. Borri and W. Langbein, J. Phys. Condens. Matter 19, 295201 (2007).
[CrossRef]

Opt. Express

Phys. Chem. Chem. Phys.

M. A. van Dijk, A. L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, and B. Lounis, Phys. Chem. Chem. Phys. 8, 3486 (2006).
[CrossRef]

Phys. Rev. Lett.

P. Borri, W. Langbein, S. Schneider, U. Woggon, R. L. Sellin, D. Ouyang, and D. Bimberg, Phys. Rev. Lett. 87, 157401 (2001).
[CrossRef]

Phys. Status Solidi C

F. Masia, W. Langbein, and P. Borri, Phys. Status Solidi C 6, 916 (2009).
[CrossRef]

Proc. Natl. Acad. Sci. USA

H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J.-X. Cheng, Proc. Natl. Acad. Sci. USA 102, 15752 (2005).
[CrossRef]

Science

D. Boyer, P. Tamarat, A. Maali, B. Lounis, and M. Orrit, Science 297, 1160 (2002).
[CrossRef]

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