Abstract

We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin (HbO2) absorption coefficients around 800nm. By calculating the ratio of the exponential decay constant of A-mode scan signal in the long-wavelength range (>800nm) over that in the short-wavelength range (<800nm), the relative oxygen saturation level of Hb can be calibrated. Such a relative level can be used for practical diagnosis application after a golden standard is built by comparing the variation of the OCT result with that of a conventional method, such as the use of a blood gas analyzer. In our experiment, the variation curve based on the SSD-OCT measurement, which has the advantages of noninvasive, real-time, and high-resolution measurements, is coincident with that of using a commercial blood gas analyzer.

© 2008 Optical Society of America

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References

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2007

L. Kagemann, G. Wollstein, M. Wojtkowski, H. Ishikawa, K. A. Townsend, M. L. Gabriele, V. J. Srinivasan, J. G. Fujimoto, and J. S. Schuman, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

2005

2003

2000

1999

L. D. Victor, Am. Fam. Physician 60, 2279 (1999).
[PubMed]

1996

D. M. Brizel, S. P. Scully, J. M. Harrelson, L. J. Layfield, J. M. Bean, L. R. Prosnitz, and M. W. Dewhirst, Cancer Res. 56, 941 (1996).
[PubMed]

Am. Fam. Physician

L. D. Victor, Am. Fam. Physician 60, 2279 (1999).
[PubMed]

Cancer Res.

D. M. Brizel, S. P. Scully, J. M. Harrelson, L. J. Layfield, J. M. Bean, L. R. Prosnitz, and M. W. Dewhirst, Cancer Res. 56, 941 (1996).
[PubMed]

Immunohematol

M. A. Popvsky and N. R. Haley, Immunohematol 16, 157 (2000).

J. Biomed. Opt.

L. Kagemann, G. Wollstein, M. Wojtkowski, H. Ishikawa, K. A. Townsend, M. L. Gabriele, V. J. Srinivasan, J. G. Fujimoto, and J. S. Schuman, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Vox Sang.

J. Bux, Vox Sang. 89, 1 (2005).
[CrossRef] [PubMed]

Other

http://omlc.ogi.edu/spectra/index.html.

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Figures (3)

Fig. 1
Fig. 1

Absorption spectra of Hb and Hb O 2 [9].

Fig. 2
Fig. 2

Oxygen pressure level in the blood drop measured with a blood gas analyzer (circles with the right ordinate) and the ratio of μ long over μ short obtained from Figs. 3a, 3b, 3c, 3d, 3e, 3f (squares with the left ordinate). The error bars for the ratio of μ long over μ short were obtained from the exponential fittings of ten sets of average A-mode scanning at various air exposure times.

Fig. 3
Fig. 3

SSD-OCT A-mode scanning results in the cases of (a) 0, (b) 2, (c) 4, (d) 6, (e) 8, and (f) 10 min air exposure periods. The fitting curves are shown, and the calibrated decay constants are given.

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