Abstract

Polarization is indicative of material anisotropy, a property that reveals structural orientation information of molecules inside the material. Herein we investigate whether polarization can be detected optoacoustically in scattering and absorbing tissues. Using a laboratory prototype of polarization-sensitive optoacoustic tomography, we demonstrate high-resolution reconstructions of dichroism contrast deep in optically diffusive tissue-mimicking phantoms. The technique is expected to enable highly accurate imaging of polarization contrast in tissues, far beyond the current capabilities of pure optical polarization-imaging approaches.

© 2008 Optical Society of America

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  1. V. E. Gusev and A. A. Karabutov, Laser Optoacoustics (American Institute of Physics, 1993).
  2. X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
    [CrossRef] [PubMed]
  3. G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
    [CrossRef] [PubMed]
  4. D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
    [CrossRef] [PubMed]
  5. S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, Opt. Express 15, 6583 (2007).
    [CrossRef] [PubMed]
  6. D. Razansky and V. Ntziachristos, Med. Phys. 34, 4293 (2007).
    [CrossRef] [PubMed]
  7. P. J. Wu and J. T. Walsh, J. Biomed. Opt. 11, 014031 (2006).
    [CrossRef] [PubMed]
  8. J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
    [CrossRef] [PubMed]
  9. V. Louis-Dorr, K. Naoun, P. Alle, A.-M. Benoit, and A. Raspiller, Appl. Opt. 43, 1515 (2004).
    [CrossRef] [PubMed]
  10. L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
    [CrossRef] [PubMed]
  11. M. Xu and R. R. Alfano, Phys. Rev. Lett. 95, 213901 (2005).
    [CrossRef] [PubMed]
  12. S. G. Demos, H. Radousky, and R. Alfano, Opt. Express 7, 23 (2000).
    [CrossRef] [PubMed]
  13. S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
    [CrossRef]
  14. S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
    [CrossRef] [PubMed]
  15. M. A. Rizzo and D. W. Piston, Biophys. J. 88, L14 (2005).
    [CrossRef]

2007 (4)

D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, Opt. Express 15, 6583 (2007).
[CrossRef] [PubMed]

D. Razansky and V. Ntziachristos, Med. Phys. 34, 4293 (2007).
[CrossRef] [PubMed]

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

2006 (1)

P. J. Wu and J. T. Walsh, J. Biomed. Opt. 11, 014031 (2006).
[CrossRef] [PubMed]

2005 (3)

G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
[CrossRef] [PubMed]

M. A. Rizzo and D. W. Piston, Biophys. J. 88, L14 (2005).
[CrossRef]

M. Xu and R. R. Alfano, Phys. Rev. Lett. 95, 213901 (2005).
[CrossRef] [PubMed]

2004 (1)

2003 (2)

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

2001 (1)

J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
[CrossRef] [PubMed]

2000 (2)

S. G. Demos, H. Radousky, and R. Alfano, Opt. Express 7, 23 (2000).
[CrossRef] [PubMed]

S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
[CrossRef]

Aaron, J.

Alfano, R.

Alfano, R. R.

M. Xu and R. R. Alfano, Phys. Rev. Lett. 95, 213901 (2005).
[CrossRef] [PubMed]

Alle, P.

Benoit, A.-M.

Bouma, B. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Bressner, J. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Claborn, K. A.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

de Boer, J. F.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Demos, S. G.

Emelianov, S.

Estrada, M.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Geday, M. A.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Gusev, V. E.

V. E. Gusev and A. A. Karabutov, Laser Optoacoustics (American Institute of Physics, 1993).

Halpern, E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Houser, S. L.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Jacques, S. L.

S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
[CrossRef]

Jin, L.-W.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Kahr, B.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Kaminsky, W.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Karabutov, A. A.

V. E. Gusev and A. A. Karabutov, Laser Optoacoustics (American Institute of Physics, 1993).

Ku, G.

G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Kuhn, J. R.

J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
[CrossRef] [PubMed]

Kurimoto, M.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Larson, T.

Lee, K.

S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
[CrossRef]

Louis-Dorr, V.

Maezawa, I.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Mallidi, S.

Nadkarni, S. K.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Naoun, K.

Ntziachristos, V.

Pang, Y.

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Park, B. H.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Pierce, M. C.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Piston, D. W.

M. A. Rizzo and D. W. Piston, Biophys. J. 88, L14 (2005).
[CrossRef]

Poenie, M.

J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
[CrossRef] [PubMed]

Radousky, H.

Raspiller, A.

Razansky, D.

Rizzo, M. A.

M. A. Rizzo and D. W. Piston, Biophys. J. 88, L14 (2005).
[CrossRef]

Roman, J. R.

S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
[CrossRef]

Sohraby, F.

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Sokolov, K.

Stoica, G.

G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Tearney, G. J.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Vinegoni, C.

Walsh, J. T.

P. J. Wu and J. T. Walsh, J. Biomed. Opt. 11, 014031 (2006).
[CrossRef] [PubMed]

Wang, L. V.

G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Wang, X.

G. Ku, X. Wang, X. Xie, G. Stoica, and L. V. Wang, Appl. Opt. 44, 770 (2005).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Whittaker, P.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

Wu, P. J.

P. J. Wu and J. T. Walsh, J. Biomed. Opt. 11, 014031 (2006).
[CrossRef] [PubMed]

Wu, Z.

J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
[CrossRef] [PubMed]

Xie, X.

Xu, M.

M. Xu and R. R. Alfano, Phys. Rev. Lett. 95, 213901 (2005).
[CrossRef] [PubMed]

Appl. Opt. (2)

Biophys. J. (2)

M. A. Rizzo and D. W. Piston, Biophys. J. 88, L14 (2005).
[CrossRef]

J. R. Kuhn, Z. Wu, and M. Poenie, Biophys. J. 80, 972 (2001).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol. (1)

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, J. Am. Coll. Cardiol. 49, 1474 (2007).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

S. L. Jacques, J. R. Roman, and K. Lee, J. Biomed. Opt. 7, 329 (2000).
[CrossRef]

P. J. Wu and J. T. Walsh, J. Biomed. Opt. 11, 014031 (2006).
[CrossRef] [PubMed]

Med. Phys. (1)

D. Razansky and V. Ntziachristos, Med. Phys. 34, 4293 (2007).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

Opt. Express (2)

Opt. Lett. (1)

Phys. Rev. Lett. (1)

M. Xu and R. R. Alfano, Phys. Rev. Lett. 95, 213901 (2005).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. USA (1)

L.-W. Jin, K. A. Claborn, M. Kurimoto, M. A. Geday, I. Maezawa, F. Sohraby, M. Estrada, W. Kaminsky, and B. Kahr, Proc. Natl. Acad. Sci. USA 100, 15294 (2003).
[CrossRef] [PubMed]

Other (1)

V. E. Gusev and A. A. Karabutov, Laser Optoacoustics (American Institute of Physics, 1993).

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Figures (3)

Fig. 1
Fig. 1

Optoacoustic polarization measurements. (a) Diagram of the experimental setup: P1, linear polarizer; HP, half-wave plate; F, polarized film; TM, turbid medium; T, transducer. (b) Relative peak-to-peak magnitude of the recorded optoacoustic response versus the angle α of the half-wave plate with respect to the polarizer P1 for different depths of the film F.

Fig. 2
Fig. 2

Optical polarization measurements. (a) Diagram of the experimental setup; (b) relative peak intensity recorded by the CCD camera versus the angle α of the half-wave plate with respect to the linear polarizer P1, for two different thicknesses of turbid slab.

Fig. 3
Fig. 3

Polarization-sensitive optoacoustic tomography (PSOT) images of a thin polarized film incorporated into heterogeneous tissue-mimicking phantom. (a) Diagram of the measurement configuration; (b) and (c) are the regular optoacoustic images for polarization angles providing maximal and minimal optoacoustic response from the film, respectively. (d) Difference image between (b) and (c).

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