Abstract

The feasibility of photoacoustic tomography (PAT) in imaging human peripheral joints in a noninvasive manner was demonstrated through studies of cadaver human fingers. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the finger at the levels of the joints were visualized successfully with satisfactory spatial resolution. The imaging depth of PAT in the near-infrared region enables the cross-sectional imaging of a human finger as a whole organ. As a novel technology with unique advantages, PAT holds promise for early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.

© 2007 Optical Society of America

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References

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    [CrossRef] [PubMed]
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2006 (2)

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

X. Wang, D. L. Chamberland, P. L. Carson, J. B. Fowlkes, R. O. Bude, and D. A. Jamadar, Med. Phys. 33, 2691 (2006).
[CrossRef] [PubMed]

2005 (1)

M. A. Anastasio, J. Zhang, X. Pan, Y. Zou, G. Ku, and L. V. Wang, IEEE Trans. Med. Imaging 24, 199 (2005).
[CrossRef] [PubMed]

2003 (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

2002 (1)

M. Xu and L.-H. Wang, IEEE Trans. Med. Imaging 21, 814 (2002).
[CrossRef] [PubMed]

1999 (2)

R. A. Kruger, K. K. Kopecky, A. M. Aisen, D. R. Reinecke, G. A. Kruger, and W. L. Kiser, Radiology 211, 275 (1999).
[PubMed]

R. O. Esenaliev, A. A. Karabutov, and A. A. Oraevsky, IEEE J. Sel. Top. Quantum Electron. 5, 981 (1999).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

R. O. Esenaliev, A. A. Karabutov, and A. A. Oraevsky, IEEE J. Sel. Top. Quantum Electron. 5, 981 (1999).
[CrossRef]

IEEE Trans. Med. Imaging (2)

M. Xu and L.-H. Wang, IEEE Trans. Med. Imaging 21, 814 (2002).
[CrossRef] [PubMed]

M. A. Anastasio, J. Zhang, X. Pan, Y. Zou, G. Ku, and L. V. Wang, IEEE Trans. Med. Imaging 24, 199 (2005).
[CrossRef] [PubMed]

Med. Phys. (1)

X. Wang, D. L. Chamberland, P. L. Carson, J. B. Fowlkes, R. O. Bude, and D. A. Jamadar, Med. Phys. 33, 2691 (2006).
[CrossRef] [PubMed]

Nat. Biotechnol. (2)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003).
[CrossRef] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Radiology (1)

R. A. Kruger, K. K. Kopecky, A. M. Aisen, D. R. Reinecke, G. A. Kruger, and W. L. Kiser, Radiology 211, 275 (1999).
[PubMed]

Other (1)

P. R. Hoskins, T. Anderson, M. Sharp, S. Meagher, T. McGillivray, and W. N. McDicken, in 2004 IEEE International Ultrasonics Symposium Proceedings (IEEE, 2004), pp. 752-755.
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Schematic of the PAT system for human peripheral joints.

Fig. 2
Fig. 2

Cross-sectional PAT images at the A, PIP and B, DIP joint regions of a human finger harvested from a fresh cadaver. Corresponding histological photographs at the C, PIP and D, DIP regions of the finger are also shown. AP, aponeurosis; PH, phalanx; SK, skin; SU, subcutaneous tissue; TE, tendon; VP, volar plate.

Fig. 3
Fig. 3

A, Cross-sectional PAT image at the PIP joint region of a human finger. B, Spatially compounded pulse-echo ultrasound image of a similar cross section in the human finger.

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