Abstract

We present a new method that can provide high resolution images of absolute optical absorption coefficient in heterogeneous turbid media. In this method, acoustic measurements in conventional photoacoustic tomography are combined with diffusing light measurements to separate the product of absorption coefficient and optical fluence or photon density. We validate this method using a series of tissuelike phantom experiments. The experimental results show that targets as small as 0.5mm in diameter with optical absorption contrasts as low as 1.5 relative to a 50mm diameter scattering background medium can be clearly detected.

© 2007 Optical Society of America

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References

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2007 (1)

J. Laufer, D. Delpy, C. Elwell, and P. Beard, Phys. Med. Biol. 52, 141 (2007).
[CrossRef]

2006 (1)

Z. Yuan and H. Jiang, Appl. Phys. Lett. 88, 231101 (2006).
[CrossRef]

2005 (2)

Z. Yuan, C. Wu, H. Zhao, and H. Jiang, Opt. Lett. 30, 3054 (2005).
[CrossRef] [PubMed]

B. Cox, S. Arridge, K. Kostli, and P. Beard, Proc. SPIE 5697, 49 (2005).
[CrossRef]

2003 (1)

2002 (1)

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, J. Acoust. Soc. Am. 112, 1536 (2002).
[CrossRef] [PubMed]

2001 (1)

A. A. Oraevsky, A. A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, and Z. Gatalica, Proc. SPIE 4256, 12 (2001).

2000 (1)

1999 (1)

R. A. Kruger, D. Reinecke, and G. Kruger, Med. Phys. 26, 1832 (1999).
[CrossRef] [PubMed]

1998 (1)

Appl. Phys. Lett. (1)

Z. Yuan and H. Jiang, Appl. Phys. Lett. 88, 231101 (2006).
[CrossRef]

J. Acoust. Soc. Am. (1)

G. Paltauf, J. Viator, S. Prahl, and S. Jacques, J. Acoust. Soc. Am. 112, 1536 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Med. Phys. (1)

R. A. Kruger, D. Reinecke, and G. Kruger, Med. Phys. 26, 1832 (1999).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (2)

Phys. Med. Biol. (1)

J. Laufer, D. Delpy, C. Elwell, and P. Beard, Phys. Med. Biol. 52, 141 (2007).
[CrossRef]

Proc. SPIE (2)

B. Cox, S. Arridge, K. Kostli, and P. Beard, Proc. SPIE 5697, 49 (2005).
[CrossRef]

A. A. Oraevsky, A. A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, and Z. Gatalica, Proc. SPIE 4256, 12 (2001).

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Figures (5)

Fig. 1
Fig. 1

Schematic of the experimental setup.

Fig. 2
Fig. 2

Reconstructed optical absorption coefficient images (units: mm 1 ) . (a) 1 mm diameter target. (b) Two targets (2 and 3 mm in diameter). (c) 0.5 mm diameter target.

Fig. 3
Fig. 3

Recovered optical absorption profiles plotted along (a) y = 1 mm , (b) y = 7 mm ( 3 mm diameter target) and y = 8 mm ( 2 mm diameter target), and (c) y = 1 mm from the images shown in Figs. 2a, 2b, 2c, respectively.

Fig. 4
Fig. 4

Reconstructed optical absorption coefficient images (units: mm 1 ) . A 2 mm diameter target having an optical contrast of (a) 2:1 and (b) 1.5:1, relative to the background.

Fig. 5
Fig. 5

Recovered optical absorption profiles plotted along (a) y = 6 and (b) 6.5 mm from the images shown in Figs. 4a, 4b, respectively.

Equations (5)

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2 p ( r , ω ) + k 0 2 p ( r , ω ) = i k 0 c 0 β Φ ( r ) C p ,
( J T J + λ I ) Δ χ = I T ( p o p c ) ,
F = min : p c p o 2 + λ χ χ ̃ 2 ,
D Ψ ( r ) μ α Ψ ( r ) = S ( r ) ,
χ 2 = i = 1 M ( Ψ i ( m ) Ψ i ( c ) ) 2 ,

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