Abstract

We used multiple optical wavelengths to study ultrasound-modulated optical tomography (UOT) in tissue phantoms. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observed variations of the ultrasound-modulated signal at various optical absorptions. The experimental variations were found to be highly correlated with predictions from Monte Carlo simulations. By irradiating the sample at two optical wavelengths, we quantitatively estimated the total concentration and the concentration ratio of double dyes in objects embedded in tissue phantoms. The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue.

© 2007 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
In vitro photoacoustic measurement of hemoglobin oxygen saturation using a single pulsed broadband supercontinuum laser source

Changho Lee, Mansik Jeon, Min Yong Jeon, Jeehyun Kim, and Chulhong Kim
Appl. Opt. 53(18) 3884-3889 (2014)

Imaging optically scattering objects with ultrasound-modulated optical tomography

Sri-Rajasekhar Kothapalli, Sava Sakadzic, Chulhong Kim, and Lihong V. Wang
Opt. Lett. 32(16) 2351-2353 (2007)

Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography

Rui Li, Daniel S. Elson, Chris Dunsby, Robert Eckersley, and Meng-Xing Tang
Opt. Express 19(8) 7299-7311 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription