Abstract

Interferometric synthetic aperture microscopy processing of optical coherence tomography data has been shown to allow computational focusing of en face planes that have traditionally been regarded as out of focus. It is shown that this focusing of the image also produces a defocusing effect in autocorrelation artifacts resulting from Fourier-domain data collection. This effect is verified experimentally and through simulation.

© 2007 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
    [CrossRef]
  2. R. Leitgeb, C. Hitzenberger, and A. Fercher, Opt. Express 11, 889 (2003).
    [CrossRef] [PubMed]
  3. R. A. Leitgeb, C. K. Hitzenberger, A. F. Fercher, and T. Bajraszewski, Opt. Lett. 28, 2201 (2003).
    [CrossRef] [PubMed]
  4. J. Zhang, J. S. Nelson, and Z. Chen, Opt. Lett. 30, 147 (2005).
    [CrossRef] [PubMed]
  5. M. Sarunic, M. A. Choma, C. Yang, and J. A. Izatt, Opt. Express 13, 957 (2005).
    [CrossRef] [PubMed]
  6. J. Ai and L. V. Wang, Appl. Phys. Lett. 88, 111115 (2006).
    [CrossRef]
  7. A. Ozcan, M. J. F. Digonnet, and G. S. Kino, J. Opt. Soc. Am. A 23, 1669 (2006).
    [CrossRef]
  8. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, J. Opt. Soc. Am. A 23, 1027 (2006).
    [CrossRef]
  9. T. S. Ralston, D. L. Marks, S. A. Boppart, and P. S. Carney, Opt. Lett. 31, 3585 (2006).
    [CrossRef] [PubMed]
  10. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
    [CrossRef]
  11. B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).
  12. R. K. Wang and Z. Ma, Phys. Med. Biol. 51, 3231 (2006).
    [CrossRef] [PubMed]
  13. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114 (2000).
    [CrossRef]
  14. P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
    [CrossRef]
  15. D. L. Marks, A. L. Oldenburg, J. J. Reynolds, and S. A. Boppart, Appl. Opt. 42, 204 (2003).
    [CrossRef] [PubMed]

2007

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

2006

2005

2003

2000

Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114 (2000).
[CrossRef]

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

1995

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Ai, J.

J. Ai and L. V. Wang, Appl. Phys. Lett. 88, 111115 (2006).
[CrossRef]

Andretzky, P.

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

Bajraszewski, T.

Boppart, S. A.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, J. Opt. Soc. Am. A 23, 1027 (2006).
[CrossRef]

T. S. Ralston, D. L. Marks, S. A. Boppart, and P. S. Carney, Opt. Lett. 31, 3585 (2006).
[CrossRef] [PubMed]

D. L. Marks, A. L. Oldenburg, J. J. Reynolds, and S. A. Boppart, Appl. Opt. 42, 204 (2003).
[CrossRef] [PubMed]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Carney, P. S.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, S. A. Boppart, and P. S. Carney, Opt. Lett. 31, 3585 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, J. Opt. Soc. Am. A 23, 1027 (2006).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Chen, Z.

Choma, M. A.

Davis, B. J.

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

de Boer, J. F.

Digonnet, M. J. F.

El-Zaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Fercher, A.

Fercher, A. F.

R. A. Leitgeb, C. K. Hitzenberger, A. F. Fercher, and T. Bajraszewski, Opt. Lett. 28, 2201 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Häusler, G.

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

Hitzenberger, C.

Hitzenberger, C. K.

R. A. Leitgeb, C. K. Hitzenberger, A. F. Fercher, and T. Bajraszewski, Opt. Lett. 28, 2201 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Izatt, J. A.

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Kiesewetter, F.

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

Kino, G. S.

Knauer, M.

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

Leitgeb, R.

Leitgeb, R. A.

Ma, Z.

R. K. Wang and Z. Ma, Phys. Med. Biol. 51, 3231 (2006).
[CrossRef] [PubMed]

Marks, D. L.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, S. A. Boppart, and P. S. Carney, Opt. Lett. 31, 3585 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, J. Opt. Soc. Am. A 23, 1027 (2006).
[CrossRef]

D. L. Marks, A. L. Oldenburg, J. J. Reynolds, and S. A. Boppart, Appl. Opt. 42, 204 (2003).
[CrossRef] [PubMed]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Nelson, J. S.

Oldenburg, A. L.

Ozcan, A.

Ralston, T. S.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, S. A. Boppart, and P. S. Carney, Opt. Lett. 31, 3585 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, J. Opt. Soc. Am. A 23, 1027 (2006).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Reynolds, J. J.

Sarunic, M.

Saxer, C.

Schlachter, S. C.

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Wang, L. V.

J. Ai and L. V. Wang, Appl. Phys. Lett. 88, 111115 (2006).
[CrossRef]

Wang, R. K.

R. K. Wang and Z. Ma, Phys. Med. Biol. 51, 3231 (2006).
[CrossRef] [PubMed]

Xiang, S.

Yang, C.

Zhang, J.

Zhao, Y.

Appl. Opt.

Appl. Phys. Lett.

J. Ai and L. V. Wang, Appl. Phys. Lett. 88, 111115 (2006).
[CrossRef]

J. Opt. Soc. Am. A

Nat. Phys.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, Nat. Phys. 3, 129 (2007).
[CrossRef]

Opt. Commun.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

R. K. Wang and Z. Ma, Phys. Med. Biol. 51, 3231 (2006).
[CrossRef] [PubMed]

Proc. SPIE

P. Andretzky, M. Knauer, F. Kiesewetter, and G. Häusler, Proc. SPIE 3915, 55 (2000).
[CrossRef]

Other

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, "Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy," J. Opt. Soc. Am. A (in press).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (2)

Fig. 1
Fig. 1

(a) The x z plane of the object and (b) the resulting OCT and (c) ISAM images with c τ 0 = 1 mm . The structures in (a) have been broadened for display. In (b) and (c) the contribution of R s r is shown in blue, R s r * (conjugate image) in green, and R s s (autocorrelation) in red. The color scale is clipped at 10% of the maximum signal so that low-level detail can be seen.

Fig. 2
Fig. 2

(a) OCT and (b) ISAM reconstructions from real data. The gray scale is clipped at 10% of the maximum value so that low-level detail can be seen.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

I T ( r , τ ) = R r r ( 0 ) + R s s ( r , 0 ) + R s r ( r , τ ) + R s r * ( r , τ ) ,
I ̂ F ( r , ω ) = S r r ( ω ) + S s s ( r , ω ) + e i ω τ 0 S s r ( r , ω ) + e i ω τ 0 S s r * ( r , ω ) ,
I F ( r , τ ) = R r r ( τ ) + R s s ( r , τ ) + R s r ( r , τ + τ 0 ) + R s r * ( r , τ τ 0 ) .
S ̃ ( Q , k ) = L ̃ ( Q , k , z ) e i 2 k z z η ̃ ( Q , z ) d z ,

Metrics