Abstract

The characteristics of a novel magneto-optic surface-plasmon-resonance (MOSPR) sensor and its use for the detection of biomolecules are presented. This physical transduction principle is based on the combination of the magneto-optic activity of magnetic materials and a surface-plasmon resonance of metallic layers. Such a combination can produce a sharp enhancement of the magneto-optic effects that strongly depends on the optical properties of the surrounding medium, allowing its use for biosensing applications. Experimental characterizations of the MOSPR sensor have shown an increase in the limit of detection by a factor of 3 in changes of refractive index and in the adsorption of biomolecules compared with standard sensors. Optimization of the metallic layers and the experimental setup could result in an improvement of the limit of detection by as much as 1 order of magnitude.

© 2006 Optical Society of America

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References

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2004 (2)

2003 (1)

2001 (1)

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

1999 (3)

J. Guo, Z. Zhu, and W. Deng, Appl. Opt. 38, 6550 (1999).
[CrossRef]

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999).
[CrossRef]

1997 (1)

1983 (1)

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

1982 (1)

C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982).
[CrossRef]

1977 (1)

P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977).
[CrossRef]

Armelles, G.

B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).

Bertrand, P.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Calle, A.

B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).

Chinowsky, T.

T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999).
[CrossRef]

Chou, C.

Deng, W.

Ferguson, P. E.

P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977).
[CrossRef]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Gershon, P. D.

Guo, J.

Hermann, C.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Ho, H. P.

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Hooper, I. R.

I. R. Hooper and J. R. Sambles, Appl. Phys. Lett. 85, 3017 (2004).
[CrossRef]

Jung, L.

T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999).
[CrossRef]

Kock, E. E.

J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

Kolomenskii, A. A.

Kong, S. K.

Kosobukin, V. A.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Krafka, C.

J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

Kuo, W. C.

Lampel, G.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Law, W. C.

Lechuga, L. M.

B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).

L. M. Lechuga, in Biosensors and Modern Biospecific Analytical Techniques, L.Gorton, ed., Comprehensive Analytical Chemistry Series, XLIV (Elsevier, 2005), Chap. 5.

Liedberg, B.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982).
[CrossRef]

Lind, T.

C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982).
[CrossRef]

Liu, C.

Lundström, I.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

Lynch, D. W.

J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

Nylander, C.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982).
[CrossRef]

Peretti, J.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Safarov, V. I.

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Sambles, J. R.

I. R. Hooper and J. R. Sambles, Appl. Phys. Lett. 85, 3017 (2004).
[CrossRef]

Schuessler, H. A.

Sepúlveda, B.

B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).

Stafsudd, O. M.

P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977).
[CrossRef]

Wallis, R. F.

P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977).
[CrossRef]

Weaver, J. H.

J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

Wu, H. T.

Wu, S. Y.

Yee, S.

T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999).
[CrossRef]

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Zhu, Z.

Appl. Opt. (2)

Appl. Phys. Lett. (1)

I. R. Hooper and J. R. Sambles, Appl. Phys. Lett. 85, 3017 (2004).
[CrossRef]

Opt. Lett. (2)

Phys. Rev. B (1)

C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001).
[CrossRef]

Physica B + C (1)

P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977).
[CrossRef]

Sens. Actuators (2)

C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982).
[CrossRef]

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

Sens. Actuators B (2)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999).
[CrossRef]

Other (3)

L. M. Lechuga, in Biosensors and Modern Biospecific Analytical Techniques, L.Gorton, ed., Comprehensive Analytical Chemistry Series, XLIV (Elsevier, 2005), Chap. 5.

J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).

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Figures (3)

Fig. 1
Fig. 1

(a) Comparison of Δ R p p R p p for a Co layer of 20 nm , a Co Au multilayer that comprises 10 nm of Co and 29.4 nm of Au, and a Cr Co Cr Au multilayer with 2 and 3 nm of Cr, 7.5 nm of Co, and 23 nm of Au. (b) Sensitivity of Δ R p p R p p in each configuration.

Fig. 2
Fig. 2

Experimental and theoretical curves of Δ R p p R p p of the Cr Co Cr Au multilayer as a function of the angle of incidence.

Fig. 3
Fig. 3

Comparison of the experimental normalized signals of the MOSPR and the SPR sensors that are due to refractive-index changes, and evaluation of their experimental sensitivities. Inset, Normalized signal of the detection of the physical adsorption of bovine serum albumin proteins.

Equations (4)

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Δ R p p R p p = R p p ( M ) R p p ( 0 ) R p p ( 0 ) ,
η = S n d = ( S A ) ( A n d ) ,
η E = η S min .
η E min = 1 η E .

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