We present a new, simple method to suppress texture pattern artifacts induced by the optical heterogeneity of tissues to improve the performance of flow imaging for real-time phase-resolved optical Doppler tomography. The method performs transverse scanning of the probe beam in the forward and then reverse directions, and it takes average of the spatial phase changes between them to obtain the final velocity image. It relies on the fact that the phase changes between successive axial scans due to the optical heterogeneity of the sample are time independent, while those due to the moving particles are time dependent. We experimentally demonstrate this method by real-time imaging of a flow phantom.

© 2006 Optical Society of America

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2006 (2)

2005 (2)

2004 (1)

2003 (1)

2002 (1)

2000 (1)

1997 (1)

Bajraszewski, T.

Berisha, F.

Bouma, B. E.

Cense, B.

Chen, T. C.

Chen, Z. P.

Cobb, M. J.

de Boer, J. F.

Ding, Z. H.

Fercher, A. F.

Hitzenberger, C. K.

Leitgeb, R. A.

Li, X. D.

Ma, Z. H.

R. K. Wang and Z. H. Ma, Phys. Med. Biol. 51, 3231 (2006).
[Crossref] [PubMed]

MacDonald, D. J.

Malekafzali, A.

Miao, J. J.

Milner, T. E.

Nassif, N.

Nelson, J. S.

Park, B. H.

Pierce, M. C.

Ren, H. W.

Saxer, C.

Schmetterer, L.

Srinivas, S.

Sun, T.

Tearney, G. J.

Vakoc, B. J.

van Gemert, M. J.

Wang, R. K.

R. K. Wang and Z. H. Ma, Phys. Med. Biol. 51, 3231 (2006).
[Crossref] [PubMed]

Wang, X. J.

White, B. R.

Wojtkowski, M.

Xiang, S. H.

Yun, S. H.

Zhang, J.

Zhao, Y. H.

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Figures (3)

Fig. 1
Fig. 1

Schematic of the spectral-domain OCT system used in this study: PC, polarization controller; C, collimator; ND, neutral-density filter; DM, double-pass mirror; L, lens; M, mirror; G, grating.

Fig. 2
Fig. 2

Imaging results from a solid scattering sample: (a) structure image; (b), (c) velocity images obtained from the conventional PR and the current methods, respectively, with Δ x = 5 μ m . (d), (e) Corresponding velocity images with Δ x = 2.5 μ m . The respective image sizes are (a)–(c) 1.4 mm × 2.5 mm and (d), (e) 1.4 mm × 1.25 mm . The velocity images were coded as gray, white represents 10 kHz , and black represents 10 kHz .

Fig. 3
Fig. 3

Imaging results from a flow phantom with (left column) Δ x = 5 μ m and (right column) Δ x = 2.5 μ m : (a), (d) structure images; (b), (e) velocity images obtained from the conventional PR method; (c), (f), images obtained from the current approach. The respective image sizes are (left column) 1.2 mm × 2.5 mm and (right column) 1.2 mm × 1.25 mm . The color coding for velocity images is the same as in Fig. 2.

Tables (1)

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Table 1 Evaluated STDs of DFS for the Velocity Images (in kHz)

Equations (2)

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Δ ϕ a ( z , x ) = Δ ϕ F ( x , z ) + k ¯ Δ z ( Δ n x + Δ x , z Δ n x , z ) ,
Δ ϕ b ( z , x ) = Δ ϕ F ( x , z ) + k ¯ Δ z ( Δ n x , z Δ n x + Δ x , z ) .