Abstract

This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source–detector fibers for tomography as well as parallel sampling of all source–detector pairs for rapid imaging. Endoscopic NIR tomography at an 8Hz frame rate was achieved in phantoms and tissue specimens with a 12mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.

© 2006 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate Part II: Experimental demonstration

Zhen Jiang, Daqing Piao, Guan Xu, Jerry W. Ritchey, G. Reed Holyoak, Kenneth E. Bartels, Charles F. Bunting, Gennady Slobodov, and Jerzy S. Krasinki
Opt. Express 16(22) 17505-17520 (2008)

Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate Part I: Simulation

Guan Xu, Daqing Piao, Cameron H. Musgrove, Charles F. Bunting, and Hamid Dehghani
Opt. Express 16(22) 17484-17504 (2008)

Photoacoustic tomography: a potential new tool for prostate cancer

Xueding Wang, William W. Roberts, Paul L. Carson, David P. Wood, and J. Brian Fowlkes
Biomed. Opt. Express 1(4) 1117-1126 (2010)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription