Abstract

X-ray imaging using a Talbot-Lau interferometer, consisting of three binary gratings, is a well-established approach to acquire x-ray phase-contrast and dark-field images with a polychromatic source. However, challenges in the production of high aspect ratio gratings limit the construction of a compact setup for high x-ray energies. In this study we consider the use of phase gratings with triangular-shaped structures in an x-ray interferometer and show that such gratings can yield high visibilities for significantly shorter propagation distances than conventional gratings with binary structures. The findings are supported by simulation and experimental results for both cases of a monochromatic and a polychromatic source.

© 2014 Optical Society of America

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    [CrossRef]
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2013 (3)

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

2012 (2)

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

2011 (3)

A. Momose, W. Yashiro, S. Harasse, H. Kuwabara, “Four-dimensional X-ray phase tomography with Talbot interferometry and white synchrotron radiation: dynamic observation of a living worm,” Opt. Express 19, 8423–8432 (2011).
[CrossRef]

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

2010 (2)

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

G.-H. Chen, N. Bevins, J. Zambelli, Z. Qi, “Small-angle scattering computed tomography (SAS-CT) using a Talbot-Lau interferometer and a rotating anode X-ray tube: theory and experiments,” Opt. Express 18, 12960–12970 (2010).
[CrossRef]

2009 (1)

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

2008 (2)

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

2007 (1)

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

2006 (1)

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

2005 (1)

2004 (1)

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

2003 (1)

1997 (1)

1995 (1)

1990 (1)

Achterhold, K.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Adam-Neumair, S.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Alkadhi, H.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

Arrizón, V.

Auweter, S.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

Auweter, S. D.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

Bamberg, F.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Bech, M.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

Bennett, E. E.

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

Bevins, N.

Bohla, A.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Boucher, R. C.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Bravin, A.

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

Bronnimann, C.

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

Bruyndonckx, P.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Bunk, O.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

Chen, G.-H.

Cloetens, P.

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13, 6296–6304 (2005).
[CrossRef]

Crosbie, J.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Cyran, C. C.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

David, C.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13, 6296–6304 (2005).
[CrossRef]

Diaz, A.

Donath, T.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

Donnelley, M.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Duc, G. L.

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

Eickelberg, O.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Eikenberry, E. F.

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

Fouras, A.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Gifford, M.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Goodman, J.

J. Goodman, Introduction to Fourier Optics, 3rd ed. (McGraw-Hill, 2005).

Grünzweig, C.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

Guggenberger, R.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

Harasse, S.

Hauser, N.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Hegedus, M. M.

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

Hempel, E.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

Herzen, J.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Hodler, J.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

Hohl, M. K.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Ingrisch, M.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

Jaffray, D. A.

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

Kenntner, J.

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Kraft, P.

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

Kubik-Huch, R. A.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Kuwabara, H.

Liu, X.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Loewen, R.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Lohmann, A. W.

López-Olazagasti, E.

Malecki, A.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Meinel, F. G.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Meiser, J.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

Mohr, J.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Momose, A.

Morgan, K.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Moseley, D. J.

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

Nikolaou, K.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Parsons, D. W.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Pauwels, B.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Pfeiffer, F.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13, 6296–6304 (2005).
[CrossRef]

Popescu, S.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

Potdevin, G.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Qi, Z.

Rapacchi, S.

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

Reiser, M.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Reiser, M. F.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

Richard, S.

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

Roessl, E.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Ruth, R.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Sasov, A.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Schleede, S.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Schulz, J.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Siewerdsen, J. H.

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

Singer, G.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Siu, K. W.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Stampanoni, M.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13, 6296–6304 (2005).
[CrossRef]

Suleski, T. J.

Tapfer, A.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Thieme, S. F.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Thomas, J. A.

Thüring, T.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Trippel, M.

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Uesugi, K.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Velroyen, A.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

Vich, M.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

Vock, P.

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

Waese, A. M.

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

Walter, M.

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Wang, Z.

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

Weitkamp, T.

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13, 6296–6304 (2005).
[CrossRef]

Wen, H.

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

Williams, I.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Yagi, N.

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

Yaroshenko, A.

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

Yashiro, W.

Yildirim, A.

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Yildirim, A. O.

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

Zambelli, J.

Ziegler, E.

Appl. Opt. (2)

Invest. Radiol. (2)

M. Stampanoni, Z. Wang, T. Thüring, C. David, E. Roessl, M. Trippel, R. A. Kubik-Huch, G. Singer, M. K. Hohl, N. Hauser, “The first analysis and clinical evaluation of native breast tissue using differential phase-contrast mammography,” Invest. Radiol. 46, 801–806 (2011).
[CrossRef]

T. Donath, F. Pfeiffer, O. Bunk, C. Grünzweig, E. Hempel, S. Popescu, P. Vock, C. David, “Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen,” Invest. Radiol. 45, 445–452 (2010).

J. Anat. (1)

D. W. Parsons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. C. Boucher, K. Uesugi, N. Yagi, K. W. Siu, “High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI),” J. Anat. 213, 217–227 (2008).
[CrossRef]

J. Opt. Soc. Am. A (1)

Med. Phys. (2)

J. H. Siewerdsen, A. M. Waese, D. J. Moseley, S. Richard, D. A. Jaffray, “Spektr: A computational tool for X-ray spectral analysis and imaging system optimization,” Med. Phys. 31, 3057–3067 (2004).
[CrossRef]

A. Tapfer, M. Bech, B. Pauwels, X. Liu, P. Bruyndonckx, A. Sasov, J. Kenntner, J. Mohr, M. Walter, J. Schulz, F. Pfeiffer, “Development of a prototype gantry system for preclinical X-ray phase-contrast computed tomography,” Med. Phys. 38, 5910–5915 (2011).
[CrossRef]

Nat. Mater. (1)

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Bronnimann, C. Grünzweig, C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7, 134–137 (2008).
[CrossRef]

Nat. Phys. (1)

F. Pfeiffer, T. Weitkamp, O. Bunk, C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources,” Nat. Phys. 2, 258–261 (2006).
[CrossRef]

Opt. Express (4)

Phys. Med. Biol. (2)

F. Pfeiffer, O. Bunk, C. David, M. Bech, G. L. Duc, A. Bravin, P. Cloetens, “High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography,” Phys. Med. Biol. 52, 6923–6930 (2007).
[CrossRef]

A. Velroyen, M. Bech, A. Malecki, A. Tapfer, A. Yaroshenko, M. Ingrisch, C. C. Cyran, S. D. Auweter, K. Nikolaou, M. Reiser, F. Pfeiffer, “Microbubbles as a scattering contrast agent for grating-based X-ray dark-field imaging,” Phys. Med. Biol. 58, N37 (2013).
[CrossRef]

Proc. Natl. Acad. Sci. U. S. A. (2)

A. Tapfer, M. Bech, A. Velroyen, J. Meiser, J. Mohr, M. Walter, J. Schulz, B. Pauwels, P. Bruyndonckx, X. Liu, A. Sasov, F. Pfeiffer, “Experimental results from a preclinical X-ray phase-contrast CT scanner,” Proc. Natl. Acad. Sci. U. S. A. 109, 15691–15696 (2012).
[CrossRef]

S. Schleede, F. G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S. F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser, F. Pfeiffer, “Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source,” Proc. Natl. Acad. Sci. U. S. A. 109, 17880–17885 (2012).
[CrossRef]

Radiology (2)

H. Wen, E. E. Bennett, M. M. Hegedus, S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251, 910–918 (2009).
[CrossRef]

A. Yaroshenko, F. G. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, S. Auweter, A. Bohla, A. O. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. F. Reiser, F. Pfeiffer, “Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner,” Radiology 269, 427–433 (2013).

Skeletal Radiol. (1)

T. Thüring, R. Guggenberger, H. Alkadhi, J. Hodler, M. Vich, Z. Wang, C. David, M. Stampanoni, “Human hand radiography using X-ray differential phase contrast combined with dark-field imaging,” Skeletal Radiol. 42, 827–835 (2013).
[CrossRef]

Other (1)

J. Goodman, Introduction to Fourier Optics, 3rd ed. (McGraw-Hill, 2005).

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Figures (6)

Fig. 1
Fig. 1

Simulated monochromatic intensity carpets for ideal (a) binary, π/2 phase grating and triangular gratings with phase shift (b) π/2, (c) 3π/2 and (d) 5π/2. (e) Simulated visibility for binary π/2, 3π/2 and 5π/2 gratings (black, dashed) and triangular π/2 (mangenta, dashed), 3π/2 (blue, bold solid) and 5π/2 (red, solid) gratings.

Fig. 2
Fig. 2

(a) 60 kVp normalized tungsten source spectrum used in the simulation. Simulated (polychromatic) visibility for ideal binary and triangular gratings with a phase shift (b) π/2, (c) π, (d) 3π/2, (e) 2π and (f) 5π/2 for the mean energy. Visibilities obtained with an analyzer grating with the same period as the phase grating.

Fig. 3
Fig. 3

Different phase grating shapes achieved by skewing binary structures.

Fig. 4
Fig. 4

Top row: directly measured intensity carpets for (a) a binary grating and (b) a binary grating, tilted to a triangular shape. Bottom row: visibilities calculated from the measured carpet for (c) binary and (d) triangular phase grating (solid, blue) and the simulated values (dashed, red).

Fig. 5
Fig. 5

Measured visibilities with a polychromatic source for different distances between the phase grating G1 and the analyzer grating G2 at 40 and 60 kVp source voltage.

Fig. 6
Fig. 6

(A) Transmission, (B) differential phase-contrast and (C) dark-field images of a phantom, consisting of plastic tubes with sand (right), water (center) and paper (left), acquired with a triangular phase grating.

Tables (2)

Tables Icon

Table 1 Propagation distances with visibility peaks for triangular-shaped gratings for a monochromatic source.

Tables Icon

Table 2 Periods of the source (P0), the phase (P1) and the analyzer (P2) gratings, needed to realize a compact (total length 1 meter) setup at 100 keV.

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