Abstract

Photoacoustic tomography is usually limited to acoustically homogeneous tissue. A hybrid scheme is developed to break this limitation by utilizing ultrasound to determine the unknown Green's function of inhomogeneous tissue. The method can effectively decrease the distortion and false contrast in images by extracting information from speckle noise. The method does not depend on the prior knowledge of tissue and the medium complexity. Moreover, the estimation of Green’s function and the photoacoustic detection are performed by the same transducer. Therefore, the scheme could be easily integrated into a classical photoacoustic tomography system and extend its application in speckle environment.

© 2013 OSA

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    [Crossref] [PubMed]
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2013 (1)

Y. Sun, K. C. P. Li, and B. O'Neill, “Multispectral photoacoustic imaging of tissue denaturation induced by high-intensity focused ultrasound treatment,” Proc. SPIE 8581, 85813H, 85813H-5 (2013).
[Crossref]

2012 (5)

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

A. Dima and V. Ntziachristos, “Non-invasive carotid imaging using optoacoustic tomography,” Opt. Express 20(22), 25044–25057 (2012).
[Crossref] [PubMed]

C. Yoon, J. Kang, S. Han, Y. Yoo, T.-K. Song, and J. H. Chang, “Enhancement of photoacoustic image quality by sound speed correction: ex vivo evaluation,” Opt. Express 20(3), 3082–3090 (2012).
[Crossref] [PubMed]

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

2011 (7)

J. R. Rajian, M. L. Fabiilli, J. B. Fowlkes, P. L. Carson, and X. Wang, “Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion,” Opt. Express 19(15), 14335–14347 (2011).
[Crossref] [PubMed]

Y. Sun, E. S. Sobel, and H. Jiang, “First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints,” Med. Phys. 38(7), 4009–4017 (2011).
[Crossref] [PubMed]

L. Nie, Z. Guo, and L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7), 076005 (2011).
[Crossref] [PubMed]

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

D. Wu, C. Tao, and X. Liu, “Photoacoustic tomography in scattering biological tissue by using virtual time reversal mirror,” J. Appl. Phys. 109(8), 084702 (2011).
[Crossref]

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Statistical optoacoustic image reconstruction using a-prior knowledge on the location of acoustic distortions,” Appl. Phys. Lett. 98(17), 171110 (2011).
[Crossref]

2010 (6)

2009 (3)

I. Vasconcelos, R. Snieder, and H. Douma, “Representation theorems and Green’s function retrieval for scattering in acoustic media,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(3), 036605 (2009).
[Crossref] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

Y. Sun, E. Sobel, and H. Jiang, “Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study,” J. Biomed. Opt. 14(6), 064002 (2009).
[Crossref] [PubMed]

2008 (1)

J.-L. Robert and M. Fink, “Green’s function estimation in speckle using the decomposition of the time reversal operator: Application to aberration correction in medical imaging,” J. Acoust. Soc. Am. 123(2), 866–877 (2008).
[Crossref] [PubMed]

2006 (3)

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

X. Jin and L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[Crossref] [PubMed]

2005 (1)

2004 (2)

Y. Xu and L. V. Wang, “Time reversal and its application to tomography with diffracting sources,” Phys. Rev. Lett. 92(3), 033902 (2004).
[Crossref] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

2003 (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

1983 (1)

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Aguirre, A.

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

Ambartsoumian, G.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Aubry, J.-F.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Boccara, A.-C.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Bossy, E.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Carson, P. L.

Chang, J. H.

Cheng, C.-C.

Coleman, D. J.

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Daoudi, K.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

David, G.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

de Mul, F. F. M.

Deán-Ben, X. L.

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Statistical optoacoustic image reconstruction using a-prior knowledge on the location of acoustic distortions,” Appl. Phys. Lett. 98(17), 171110 (2011).
[Crossref]

Dima, A.

Douma, H.

I. Vasconcelos, R. Snieder, and H. Douma, “Representation theorems and Green’s function retrieval for scattering in acoustic media,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(3), 036605 (2009).
[Crossref] [PubMed]

Elbaum, M.

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Erpelding, T. N.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express 1(1), 278–284 (2010).
[Crossref] [PubMed]

Fabiilli, M. L.

Feleppa, E. J.

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Fink, M.

J.-L. Robert and M. Fink, “Green’s function estimation in speckle using the decomposition of the time reversal operator: Application to aberration correction in medical imaging,” J. Acoust. Soc. Am. 123(2), 866–877 (2008).
[Crossref] [PubMed]

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Fowlkes, J. B.

Gamelin, J.

Greenebaum, M.

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Guo, P.

Guo, Z.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

L. Nie, Z. Guo, and L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7), 076005 (2011).
[Crossref] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett. 35, 2067–2069 (2010).
[Crossref] [PubMed]

Han, S.

He, J.

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett. 35, 2067–2069 (2010).
[Crossref] [PubMed]

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
[Crossref] [PubMed]

Huang, F.

Jankovic, L.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express 1(1), 278–284 (2010).
[Crossref] [PubMed]

Jiang, H.

Y. Sun, E. S. Sobel, and H. Jiang, “First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints,” Med. Phys. 38(7), 4009–4017 (2011).
[Crossref] [PubMed]

J. Xiao, L. Yao, Y. Sun, E. S. Sobel, J. He, and H. Jiang, “Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints,” Opt. Express 18(14), 14359–14365 (2010).
[Crossref] [PubMed]

Y. Sun, E. Sobel, and H. Jiang, “Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study,” J. Biomed. Opt. 14(6), 064002 (2009).
[Crossref] [PubMed]

Jin, X.

X. Jin and L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[Crossref] [PubMed]

Kang, J.

Kim, C.

Kolkman, R. G. M.

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Kuchment, P.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Li, K. C. P.

Y. Sun, K. C. P. Li, and B. O'Neill, “Multispectral photoacoustic imaging of tissue denaturation induced by high-intensity focused ultrasound treatment,” Proc. SPIE 8581, 85813H, 85813H-5 (2013).
[Crossref]

Li, M.-L.

Liu, X.

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

D. Wu, C. Tao, and X. Liu, “Photoacoustic tomography in scattering biological tissue by using virtual time reversal mirror,” J. Appl. Phys. 109(8), 084702 (2011).
[Crossref]

C. Tao and X. Liu, “Reconstruction of high quality photoacoustic tomography with a limited-view scanning,” Opt. Express 18(3), 2760–2766 (2010).
[Crossref] [PubMed]

Liu, X. J.

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

Lizzi, F. L.

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

Maslov, K.

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

Maurudis, A.

Montaldo, G.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Nie, L.

L. Nie, Z. Guo, and L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7), 076005 (2011).
[Crossref] [PubMed]

Ntziachristos, V.

A. Dima and V. Ntziachristos, “Non-invasive carotid imaging using optoacoustic tomography,” Opt. Express 20(22), 25044–25057 (2012).
[Crossref] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Statistical optoacoustic image reconstruction using a-prior knowledge on the location of acoustic distortions,” Appl. Phys. Lett. 98(17), 171110 (2011).
[Crossref]

O'Neill, B.

Y. Sun, K. C. P. Li, and B. O'Neill, “Multispectral photoacoustic imaging of tissue denaturation induced by high-intensity focused ultrasound treatment,” Proc. SPIE 8581, 85813H, 85813H-5 (2013).
[Crossref]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Pashley, M. D.

Percival, C.

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

Rajian, J. R.

Razansky, D.

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Statistical optoacoustic image reconstruction using a-prior knowledge on the location of acoustic distortions,” Appl. Phys. Lett. 98(17), 171110 (2011).
[Crossref]

Robert, J. L.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Robert, J.-L.

J.-L. Robert and M. Fink, “Green’s function estimation in speckle using the decomposition of the time reversal operator: Application to aberration correction in medical imaging,” J. Acoust. Soc. Am. 123(2), 866–877 (2008).
[Crossref] [PubMed]

Siphanto, R. I.

Snieder, R.

I. Vasconcelos, R. Snieder, and H. Douma, “Representation theorems and Green’s function retrieval for scattering in acoustic media,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(3), 036605 (2009).
[Crossref] [PubMed]

Sobel, E.

Y. Sun, E. Sobel, and H. Jiang, “Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study,” J. Biomed. Opt. 14(6), 064002 (2009).
[Crossref] [PubMed]

Sobel, E. S.

Y. Sun, E. S. Sobel, and H. Jiang, “First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints,” Med. Phys. 38(7), 4009–4017 (2011).
[Crossref] [PubMed]

J. Xiao, L. Yao, Y. Sun, E. S. Sobel, J. He, and H. Jiang, “Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints,” Opt. Express 18(14), 14359–14365 (2010).
[Crossref] [PubMed]

Song, T.-K.

Steenbergen, W.

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Sun, Y.

Y. Sun, K. C. P. Li, and B. O'Neill, “Multispectral photoacoustic imaging of tissue denaturation induced by high-intensity focused ultrasound treatment,” Proc. SPIE 8581, 85813H, 85813H-5 (2013).
[Crossref]

Y. Sun, E. S. Sobel, and H. Jiang, “First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints,” Med. Phys. 38(7), 4009–4017 (2011).
[Crossref] [PubMed]

J. Xiao, L. Yao, Y. Sun, E. S. Sobel, J. He, and H. Jiang, “Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints,” Opt. Express 18(14), 14359–14365 (2010).
[Crossref] [PubMed]

Y. Sun, E. Sobel, and H. Jiang, “Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study,” J. Biomed. Opt. 14(6), 064002 (2009).
[Crossref] [PubMed]

Tanter, M.

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Tao, C.

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

D. Wu, C. Tao, and X. Liu, “Photoacoustic tomography in scattering biological tissue by using virtual time reversal mirror,” J. Appl. Phys. 109(8), 084702 (2011).
[Crossref]

C. Tao and X. Liu, “Reconstruction of high quality photoacoustic tomography with a limited-view scanning,” Opt. Express 18(3), 2760–2766 (2010).
[Crossref] [PubMed]

Thumma, K. K.

Tseng, Y.-C.

van Adrichem, L. N. A.

van Leeuwen, T. G.

van Neck, J. W.

Vasconcelos, I.

I. Vasconcelos, R. Snieder, and H. Douma, “Representation theorems and Green’s function retrieval for scattering in acoustic media,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(3), 036605 (2009).
[Crossref] [PubMed]

Wang, L. V.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

L. Nie, Z. Guo, and L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7), 076005 (2011).
[Crossref] [PubMed]

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
[Crossref] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett. 35, 2067–2069 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express 1(1), 278–284 (2010).
[Crossref] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

X. Jin and L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[Crossref] [PubMed]

Y. Xu and L. V. Wang, “Time reversal and its application to tomography with diffracting sources,” Phys. Rev. Lett. 92(3), 033902 (2004).
[Crossref] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wang, X.

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

J. R. Rajian, M. L. Fabiilli, J. B. Fowlkes, P. L. Carson, and X. Wang, “Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion,” Opt. Express 19(15), 14335–14347 (2011).
[Crossref] [PubMed]

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wang, Y.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Wu, D.

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

D. Wu, C. Tao, and X. Liu, “Photoacoustic tomography in scattering biological tissue by using virtual time reversal mirror,” J. Appl. Phys. 109(8), 084702 (2011).
[Crossref]

Xia, J.

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

Xiao, J.

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Xu, Y.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Y. Xu and L. V. Wang, “Time reversal and its application to tomography with diffracting sources,” Phys. Rev. Lett. 92(3), 033902 (2004).
[Crossref] [PubMed]

Yao, L.

Yoo, Y.

Yoon, C.

Zhu, Q.

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

Appl. Phys. Lett. (3)

D. Wu, X. Wang, C. Tao, and X. J. Liu, “Limited-view photoacoustic tomography utilizing backscatterers as virtual transducers,” Appl. Phys. Lett. 99(24), 244102 (2011).
[Crossref]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Statistical optoacoustic image reconstruction using a-prior knowledge on the location of acoustic distortions,” Appl. Phys. Lett. 98(17), 171110 (2011).
[Crossref]

E. Bossy, K. Daoudi, A.-C. Boccara, M. Tanter, J.-F. Aubry, G. Montaldo, and M. Fink, “Time reversal of photoacoustic waves,” Appl. Phys. Lett. 89(18), 184108 (2006).
[Crossref]

Biomed. Opt. Express (1)

Chin. Phys. B (1)

D. Wu, C. Tao, X. Liu, and X. Wang, “Influence of limited-view scanning on depth imaging of photoacoustic tomography,” Chin. Phys. B 21(1), 014301 (2012).
[Crossref]

J. Acoust. Soc. Am. (2)

F. L. Lizzi, M. Greenebaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, “Theoretical Framework for Spectrum Analysis in Ultrasonic Tissue Characterization,” J. Acoust. Soc. Am. 73(4), 1366–1373 (1983).
[Crossref] [PubMed]

J.-L. Robert and M. Fink, “Green’s function estimation in speckle using the decomposition of the time reversal operator: Application to aberration correction in medical imaging,” J. Acoust. Soc. Am. 123(2), 866–877 (2008).
[Crossref] [PubMed]

J. Appl. Phys. (1)

D. Wu, C. Tao, and X. Liu, “Photoacoustic tomography in scattering biological tissue by using virtual time reversal mirror,” J. Appl. Phys. 109(8), 084702 (2011).
[Crossref]

J. Biomed. Opt. (5)

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
[Crossref] [PubMed]

Y. Sun, E. Sobel, and H. Jiang, “Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study,” J. Biomed. Opt. 14(6), 064002 (2009).
[Crossref] [PubMed]

L. Nie, Z. Guo, and L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt. 16(7), 076005 (2011).
[Crossref] [PubMed]

J. Xia, Z. Guo, K. Maslov, A. Aguirre, Q. Zhu, C. Percival, and L. V. Wang, “Three-dimensional photoacoustic tomography based on the focal-line concept,” J. Biomed. Opt. 16(9), 090505 (2011).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J. L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Med. Phys. (2)

Y. Sun, E. S. Sobel, and H. Jiang, “First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints,” Med. Phys. 38(7), 4009–4017 (2011).
[Crossref] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Opt. Express (8)

R. I. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem, and W. Steenbergen, “Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis,” Opt. Express 13(1), 89–95 (2005).
[Crossref] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

C. Tao and X. Liu, “Reconstruction of high quality photoacoustic tomography with a limited-view scanning,” Opt. Express 18(3), 2760–2766 (2010).
[Crossref] [PubMed]

M.-L. Li, Y.-C. Tseng, and C.-C. Cheng, “Model-based correction of finite aperture effect in photoacoustic tomography,” Opt. Express 18(25), 26285–26292 (2010).
[Crossref] [PubMed]

J. R. Rajian, M. L. Fabiilli, J. B. Fowlkes, P. L. Carson, and X. Wang, “Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion,” Opt. Express 19(15), 14335–14347 (2011).
[Crossref] [PubMed]

C. Yoon, J. Kang, S. Han, Y. Yoo, T.-K. Song, and J. H. Chang, “Enhancement of photoacoustic image quality by sound speed correction: ex vivo evaluation,” Opt. Express 20(3), 3082–3090 (2012).
[Crossref] [PubMed]

A. Dima and V. Ntziachristos, “Non-invasive carotid imaging using optoacoustic tomography,” Opt. Express 20(22), 25044–25057 (2012).
[Crossref] [PubMed]

J. Xiao, L. Yao, Y. Sun, E. S. Sobel, J. He, and H. Jiang, “Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints,” Opt. Express 18(14), 14359–14365 (2010).
[Crossref] [PubMed]

Opt. Lett. (1)

Phys. Med. Biol. (1)

X. Jin and L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[Crossref] [PubMed]

Phys. Rev. E Stat. Nonlin. Soft Matter Phys. (1)

I. Vasconcelos, R. Snieder, and H. Douma, “Representation theorems and Green’s function retrieval for scattering in acoustic media,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 80(3), 036605 (2009).
[Crossref] [PubMed]

Phys. Rev. Lett. (1)

Y. Xu and L. V. Wang, “Time reversal and its application to tomography with diffracting sources,” Phys. Rev. Lett. 92(3), 033902 (2004).
[Crossref] [PubMed]

Proc. SPIE (1)

Y. Sun, K. C. P. Li, and B. O'Neill, “Multispectral photoacoustic imaging of tissue denaturation induced by high-intensity focused ultrasound treatment,” Proc. SPIE 8581, 85813H, 85813H-5 (2013).
[Crossref]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

The sketch of the scenario considered. Scatters (circles) are randomly distributed in tissue. A 16-element transducer array is utilized to send and record ultrasound, and record generated photoacoustic signals.

Fig. 2
Fig. 2

Extracting PA images from speckle noise. (a) The detected PA field. (b) The image by excluding speckle noise. (c) Image by including speckle noise.

Fig. 3
Fig. 3

Influence of signal length on the image quality. (a) FWHM. (b) Amplitude ratio between the two absorbers.

Fig. 4
Fig. 4

Influence of transducer array length on the performance of the US-PA method. (a) FWHM. (b) Amplitude ratio between the two absorbers.

Equations (6)

Equations on this page are rendered with MathJax. Learn more.

p( r d ,t )= 0 T d t 0 R q( r 0 , t 0 )g( r d ,t | r 0 , t 0 )d r 0 ,
p( r d ,t )= 0 T d t 0 R q( r 0 , t 0 )[ g h ( r d ,t | r 0 , t 0 )+ g s ( r d ,t | r 0 , t 0 ) ]d r d .
p TR ( r 0 ,t )= 0 T d t 1 Σ d r d p d ( r d ,T t 1 )[ g h ( r 0 ,t | r d , t 1 )+ g s ( r 0 ,t | r d , t 1 ) ] ,
G s ( r d (i) ,r,ω )= r d (j) Σ ϕ( ω ) H s ( j,i,ω ) G h * ( r d (j) ,r,ω )dS ,
G s ( r d (i) ,r,ω ) j=1 N ϕ( ω ) H s ( j,i,ω ) G h ( r d (j) ,r,ω ) .
p TR ( r 0 ,T )~ i=1 N w(i, r 0 ) p d (i) ( | r d (i) r 0 | /c ) ,

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