Abstract

Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm at 100kHz axial scan rates using single mode fiber optics and a multiplexing approach. Unlike previously reported PS-OCT multiplexing schemes, the method uses a passive polarization delay unit and does not require active polarization modulating devices. This advance decreases system cost and avoids complex synchronization requirements. The polarization delay unit was implemented in the sample beam path in order to simultaneously illuminate the sample with two different polarization states. The orthogonal polarization components for the depth-multiplexed signals from the two input states were detected using dual balanced detection. PS-OCT images were computed using Jones calculus. 3D PS-OCT imaging was performed in the human and rat retina. In addition to standard OCT images, PS-OCT images were generated using contrast form birefringence and depolarization. Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images.

© 2012 OSA

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2011 (6)

M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Polarization sensitive optical coherence tomography in the human eye,” Prog. Retin. Eye Res. 30(6), 431–451 (2011).
[CrossRef] [PubMed]

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

Z. H. Lu, D. K. Kasaragod, and S. J. Matcher, “Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography,” J. Biomed. Opt. 16(7), 070502 (2011).
[CrossRef] [PubMed]

K. H. Kim, B. H. Park, Y. P. Tu, T. Hasan, B. Lee, J. A. Li, and J. F. de Boer, “Polarization-sensitive optical frequency domain imaging based on unpolarized light,” Opt. Express 19(2), 552–561 (2011).
[CrossRef] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-Carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express 19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

2010 (9)

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

T. Schmoll, E. Götzinger, M. Pircher, C. K. Hitzenberger, and R. A. Leitgeb, “Single-camera polarization-sensitive spectral-domain OCT by spatial frequency encoding,” Opt. Lett. 35(2), 241–243 (2010).
[CrossRef] [PubMed]

M. K. Al-Qaisi and T. Akkin, “Swept-source polarization-sensitive optical coherence tomography based on polarization-maintaining fiber,” Opt. Express 18(4), 3392–3403 (2010).
[CrossRef] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

W. Y. Oh, B. J. Vakoc, M. Shishkov, G. J. Tearney, and B. E. Bouma, “>400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging,” Opt. Lett. 35(17), 2919–2921 (2010).
[CrossRef] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[CrossRef] [PubMed]

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

2009 (4)

2008 (6)

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, M. Shishkov, A. E. Desjardins, B. H. Park, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing,” Opt. Express 16(2), 1096–1103 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

2007 (2)

C. M. Fan, Y. Wang, and R. K. K. Wang, “Spectral domain polarization sensitive optical coherence tomography achieved by single camera detection,” Opt. Express 15(13), 7950–7961 (2007).
[CrossRef] [PubMed]

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

2006 (2)

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

2004 (9)

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[CrossRef] [PubMed]

S. G. Guo, J. Zhang, L. Wang, J. S. Nelson, and Z. P. Chen, “Depth-resolved birefringence and differential optical axis orientation measurements with fiber-based polarization-sensitive optical coherence tomography,” Opt. Lett. 29(17), 2025–2027 (2004).
[CrossRef] [PubMed]

B. Hyle Park, M. C. Pierce, B. Cense, and J. F. de Boer, “Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components,” Opt. Lett. 29(21), 2512–2514 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

J. Zhang, W. Jung, J. S. Nelson, and Z. Chen, “Full range polarization-sensitive Fourier domain optical coherence tomography,” Opt. Express 12(24), 6033–6039 (2004).
[CrossRef] [PubMed]

2003 (3)

2002 (1)

S. Jiao and L. V. Wang, “Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography,” J. Biomed. Opt. 7(3), 350–358 (2002).
[CrossRef] [PubMed]

2001 (4)

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

C. K. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. F. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
[CrossRef] [PubMed]

1997 (1)

1992 (1)

1990 (1)

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Ahlers, C.

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

Akkin, T.

Al-Qaisi, M. K.

Bagnaninchi, P. O.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Barry, S.

Baumann, B.

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[CrossRef] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

E. Götzinger, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography,” Opt. Express 17(25), 22704–22717 (2009).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

Biedermann, B. R.

Bonesi, M.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Bouma, B. E.

Bursell, S. E.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Cable, A.

Cable, A. E.

Carvalho, M.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Cense, B.

Chen, T. C.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Chen, Y. L.

Chen, Z.

Chen, Z. P.

Choma, M. A.

Clermont, A.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Coleman, A.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

de Boer, J. F.

K. H. Kim, B. H. Park, Y. P. Tu, T. Hasan, B. Lee, J. A. Li, and J. F. de Boer, “Polarization-sensitive optical frequency domain imaging based on unpolarized light,” Opt. Express 19(2), 552–561 (2011).
[CrossRef] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, M. Shishkov, A. E. Desjardins, B. H. Park, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing,” Opt. Express 16(2), 1096–1103 (2008).
[CrossRef] [PubMed]

B. Hyle Park, M. C. Pierce, B. Cense, and J. F. de Boer, “Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components,” Opt. Lett. 29(21), 2512–2514 (2004).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003).
[CrossRef] [PubMed]

J. F. de Boer, T. E. Milner, M. J. C. van Gemert, and J. S. Nelson, “Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography,” Opt. Lett. 22(12), 934–936 (1997).
[CrossRef] [PubMed]

Desjardins, A. E.

Dreher, A. W.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Duan, L.

Duan, Y. L.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Duker, J. S.

Eigenwillig, C. M.

El Haj, A.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Fan, C. M.

Fercher, A. F.

Findl, O.

Fujimoto, J. G.

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[CrossRef] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[CrossRef] [PubMed]

M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B 9(6), 903–908 (1992).
[CrossRef]

Fukuchi, T.

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

Geitzenauer, W.

Goetzinger, E.

Golbaz, I.

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

Gonzalez-Pola, C.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Gora, M.

Gorczynska, I.

Goto, H.

Götzinger, E.

T. Schmoll, E. Götzinger, M. Pircher, C. K. Hitzenberger, and R. A. Leitgeb, “Single-camera polarization-sensitive spectral-domain OCT by spatial frequency encoding,” Opt. Lett. 35(2), 241–243 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

E. Götzinger, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography,” Opt. Express 17(25), 22704–22717 (2009).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

Gregori, G.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Guo, S. G.

Gupta, P. K.

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

Hackam, A.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Hasan, T.

Hauswirth, W. W.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Hee, M. R.

Hirn, C.

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

Hitzenberger, C. K.

M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Polarization sensitive optical coherence tomography in the human eye,” Prog. Retin. Eye Res. 30(6), 431–451 (2011).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

T. Schmoll, E. Götzinger, M. Pircher, C. K. Hitzenberger, and R. A. Leitgeb, “Single-camera polarization-sensitive spectral-domain OCT by spatial frequency encoding,” Opt. Lett. 35(2), 241–243 (2010).
[CrossRef] [PubMed]

E. Götzinger, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography,” Opt. Express 17(25), 22704–22717 (2009).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[CrossRef] [PubMed]

C. K. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. F. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
[CrossRef] [PubMed]

Hori, K.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Horio, N.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Hornegger, J.

Huang, D.

Huang, H. E. L.

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

Huber, R.

Hunter, K.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Hyle Park, B.

Iwaya, K.

Izatt, J. A.

Jiang, J.

Jiao, S.

S. Jiao and L. V. Wang, “Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography,” J. Biomed. Opt. 7(3), 350–358 (2002).
[CrossRef] [PubMed]

Jiao, S. L.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Jockovich, M. E.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Jung, W.

Jung, W. Q.

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

Kachi, S.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Kaluzny, B. J.

Karnowski, K.

Kasaragod, D. K.

Z. H. Lu, D. K. Kasaragod, and S. J. Matcher, “Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography,” J. Biomed. Opt. 16(7), 070502 (2011).
[CrossRef] [PubMed]

Kawana, K.

Keikhanzadeh, K.

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

Kim, K. H.

Klein, T.

Ko, T. H.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[CrossRef] [PubMed]

Kowalczyk, A.

Kraus, M. F.

Lee, B.

Leitgeb, R.

Leitgeb, R. A.

Lem, J.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Lewin, A. S.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Li, J. A.

Li, Q.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Lim, Y.

Liu, G. J.

Liu, J. J.

Lu, Z. H.

Z. H. Lu, D. K. Kasaragod, and S. J. Matcher, “Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography,” J. Biomed. Opt. 16(7), 070502 (2011).
[CrossRef] [PubMed]

Maffulli, G.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Maffulli, N.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Makita, S.

Matcher, S. J.

Z. H. Lu, D. K. Kasaragod, and S. J. Matcher, “Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography,” J. Biomed. Opt. 16(7), 070502 (2011).
[CrossRef] [PubMed]

Matsumura, M.

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

Meglinski, I.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Michels, S.

Milner, T. E.

Miura, M.

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

Miyake, Y.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Miyazawa, A.

Neel, V.

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

Nelson, J. S.

Oh, W. Y.

Okamoto, Y.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Park, B. H.

Park, H.

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

Phelan, C.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Pierce, M. C.

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

B. Hyle Park, M. C. Pierce, B. Cense, and J. F. de Boer, “Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components,” Opt. Lett. 29(21), 2512–2514 (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003).
[CrossRef] [PubMed]

Pircher, M.

M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Polarization sensitive optical coherence tomography in the human eye,” Prog. Retin. Eye Res. 30(6), 431–451 (2011).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

T. Schmoll, E. Götzinger, M. Pircher, C. K. Hitzenberger, and R. A. Leitgeb, “Single-camera polarization-sensitive spectral-domain OCT by spatial frequency encoding,” Opt. Lett. 35(2), 241–243 (2010).
[CrossRef] [PubMed]

E. Götzinger, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography,” Opt. Express 17(25), 22704–22717 (2009).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

C. K. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. F. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
[CrossRef] [PubMed]

Potsaid, B.

Prager, F.

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

Puliafito, C. A.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Quigley, H.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Rao, K. D.

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

Reiter, K.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Reitze, D. H.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Ruggeri, M.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Sarunic, M. V.

Sattmann, H.

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

Schlanitz, F.

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

Schmidt-Erfurth, U.

M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Polarization sensitive optical coherence tomography in the human eye,” Prog. Retin. Eye Res. 30(6), 431–451 (2011).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

Schmoll, T.

Schuman, J. S.

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[CrossRef] [PubMed]

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Schütze, C.

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

Sharma, P.

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

Shaw, B.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Shishkov, M.

Shou, K.

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

Song, Q. H.

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

Srinivas, S. M.

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

Srinivasan, V. J.

Sticker, M.

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

C. K. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. F. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
[CrossRef] [PubMed]

Strasswimmer, J.

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

Swanson, E. A.

Szkulmowski, M.

Takahashi, K.

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

Tearney, G. J.

Terasaki, H.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Timmers, A. M.

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

Tu, Y. P.

Vakoc, B. J.

van Gemert, M. J. C.

Vass, C.

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

Verma, Y.

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

Wang, L.

Wang, L. V.

S. Jiao and L. V. Wang, “Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography,” J. Biomed. Opt. 7(3), 350–358 (2002).
[CrossRef] [PubMed]

Wang, R. K. K.

Wang, Y.

Wehbe, H.

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

Weinreb, R. N.

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Wieser, W.

Wojtkowski, M.

Xie, T. Q.

Yamamoto, E.

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

Yamanari, M.

Yang, C. H.

Yang, Y.

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Yasuno, Y.

Yatagai, T.

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

Yu, L. F.

Yun, S. H.

Zhang, J.

Appl. Opt. (1)

Arch. Ophthalmol. (2)

N. Horio, S. Kachi, K. Hori, Y. Okamoto, E. Yamamoto, H. Terasaki, and Y. Miyake, “Progressive change of optical coherence tomography scans in retinal degeneration slow mice,” Arch. Ophthalmol. 119(9), 1329–1332 (2001).
[PubMed]

R. N. Weinreb, A. W. Dreher, A. Coleman, H. Quigley, B. Shaw, and K. Reiter, “Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness,” Arch. Ophthalmol. 108(4), 557–560 (1990).
[CrossRef] [PubMed]

Biomed. Opt. Express (1)

Graefes Arch. Clin. Exp. Ophthalmol. (1)

T. Fukuchi, K. Takahashi, K. Shou, and M. Matsumura, “Optical coherence tomography (OCT) findings in normal retina and laser-induced choroidal neovascularization in rats,” Graefes Arch. Clin. Exp. Ophthalmol. 239(1), 41–46 (2001).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci. (5)

V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S. E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5522–5528 (2006).
[CrossRef] [PubMed]

M. Ruggeri, H. Wehbe, S. L. Jiao, G. Gregori, M. E. Jockovich, A. Hackam, Y. L. Duan, and C. A. Puliafito, “In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(4), 1808–1814 (2007).
[CrossRef] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Q. Li, A. M. Timmers, K. Hunter, C. Gonzalez-Pola, A. S. Lewin, D. H. Reitze, and W. W. Hauswirth, “Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse,” Invest. Ophthalmol. Vis. Sci. 42(12), 2981–2989 (2001).
[PubMed]

J Biophoton. (1)

E. Götzinger, M. Pircher, B. Baumann, C. Hirn, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: a comparison,” J Biophoton. 1(2), 129–139 (2008).
[CrossRef] [PubMed]

J. Biomed. Opt. (7)

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

S. M. Srinivas, J. F. de Boer, H. Park, K. Keikhanzadeh, H. E. L. Huang, J. Zhang, W. Q. Jung, Z. P. Chen, and J. S. Nelson, “Determination of burn depth by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 207–212 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, and J. F. de Boer, “Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,” J. Biomed. Opt. 9(2), 292–298 (2004).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, H. Sattmann, C. Schütze, F. Schlanitz, C. Ahlers, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(6), 061704 (2010).
[CrossRef] [PubMed]

S. Jiao and L. V. Wang, “Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography,” J. Biomed. Opt. 7(3), 350–358 (2002).
[CrossRef] [PubMed]

Z. H. Lu, D. K. Kasaragod, and S. J. Matcher, “Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography,” J. Biomed. Opt. 16(7), 070502 (2011).
[CrossRef] [PubMed]

J. Opt. (1)

P. Sharma, Y. Verma, K. D. Rao, and P. K. Gupta, “Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source,” J. Opt. 13(11), 115301 (2011).
[CrossRef]

J. Opt. Soc. Am. B (1)

Opt. Express (21)

C. K. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. F. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[CrossRef] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11(18), 2183–2189 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. K. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[CrossRef] [PubMed]

J. Zhang, W. Jung, J. S. Nelson, and Z. Chen, “Full range polarization-sensitive Fourier domain optical coherence tomography,” Opt. Express 12(24), 6033–6039 (2004).
[CrossRef] [PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[CrossRef] [PubMed]

C. M. Fan, Y. Wang, and R. K. K. Wang, “Spectral domain polarization sensitive optical coherence tomography achieved by single camera detection,” Opt. Express 15(13), 7950–7961 (2007).
[CrossRef] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, M. Shishkov, A. E. Desjardins, B. H. Park, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing,” Opt. Express 16(2), 1096–1103 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

M. Gora, K. Karnowski, M. Szkulmowski, B. J. Kaluzny, R. Huber, A. Kowalczyk, and M. Wojtkowski, “Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range,” Opt. Express 17(17), 14880–14894 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-Carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express 19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

E. Götzinger, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography,” Opt. Express 17(25), 22704–22717 (2009).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. K. Al-Qaisi and T. Akkin, “Swept-source polarization-sensitive optical coherence tomography based on polarization-maintaining fiber,” Opt. Express 18(4), 3392–3403 (2010).
[CrossRef] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[CrossRef] [PubMed]

K. H. Kim, B. H. Park, Y. P. Tu, T. Hasan, B. Lee, J. A. Li, and J. F. de Boer, “Polarization-sensitive optical frequency domain imaging based on unpolarized light,” Opt. Express 19(2), 552–561 (2011).
[CrossRef] [PubMed]

Opt. Lett. (6)

Phys. Med. Biol. (1)

P. O. Bagnaninchi, Y. Yang, M. Bonesi, G. Maffulli, C. Phelan, I. Meglinski, A. El Haj, and N. Maffulli, “In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography,” Phys. Med. Biol. 55(13), 3777–3787 (2010).
[CrossRef] [PubMed]

Prog. Retin. Eye Res. (1)

M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Polarization sensitive optical coherence tomography in the human eye,” Prog. Retin. Eye Res. 30(6), 431–451 (2011).
[CrossRef] [PubMed]

Other (1)

V. Jayaraman, J. Jiang, H. Li, P. J. S. Heim, G. D. Cole, B. Potsaid, J. G. Fujimoto, and A. Cable, “OCT imaging up to 760 kHz axial scan rate using single-mode 1310nm MEMS-tunable VCSELs with >100nm tuning range,” in Lasers and Electro-Optics (CLEO),2011Conference on, 2011), 1–2.

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Figures (5)

Fig. 1
Fig. 1

Swept source / Fourier domain OCT with a passive polarization delay unit. (A) Scheme of the setup. In a single-mode fiber based Mach-Zehnder interferometer, a polarization delay unit is included in the sample illumination path. The sample and reference beam interfere at the non-polarizing beam splitter and are then split up into orthogonal polarization components by means of polarizing beam splitters. The two orthogonal polarization channels are detected by separate balanced receivers. (B) Scheme of the passive delay unit. (C) Exemplary image of the phase difference between the orthogonal detection channels. The OCT signals originating from the two incident states are separated by Δz = 1.8mm in depth. Acronyms: Polarization controller PC, galvanometer scanner GS, polarizing beam splitter PBS, non-polarizing beam splitter NPBS, quarter wave plate QWP, mirror M.

Fig. 2
Fig. 2

High speed volumetric PS-OCT imaging in the human retina. (A-D) Snapshot PS-OCT imaging of the optic disk region. (A) Volumetric rendering of a 3D reflectivity data set. (B) Rendering of the corresponding phase retardation data. Increasing phase retardation can be observed in the birefringent RNFL. (C) Reflectivity B-scan image. (D) Corresponding phase retardation image. Phase retardation values between 0° and 180° are encoded in a color map ranging from blue to red. Image pixels below a reflectivity threshold are displayed in grey. (E-H) PS-OCT imaging of the macula with dense sampling. (E) OCT fundus projection image. (F) Reflectivity B-scan image. (G) Phase retardation image. (H) Detail of (G) showing the polarization preserving photoreceptor layer and polarization scrambling in the RPE (purple arrows). All scale bars in microns.

Fig. 3
Fig. 3

Wide field PS-OCT imaging of the human retina. (A) Fundus projection image. As indicated in the color fundus photo (B), the scanned area covers a range of 26° × 26° on the retina. (C) Reflectivity B-scan image on the location indicated by the arrow in (A). (D) Corresponding phase retardation image (color scale: 0°– 180°). Increasing phase retardation due to RNFL birefringence can be observed by a color change from blue to yellow. (E) Wide field fundus image of phase retardation (color scale: 0° – 27°). Strong birefringence can be observed around the optic disk along the nerve fiber bundles. (F) Scanning laser polarimetry image of the same eye taken with the Zeiss GDx. Color map below. The scanned area of 15° × 15° is indicated by the dashed rectangle in (E).

Fig. 4
Fig. 4

Retinal PS-OCT imaging in rats. (A-E) Sprague Dawley rat. (F-K) Long Evans rat. (A, G) Fundus projection images showing the retinal vasculature around the optic disk. (B, C) Reflectivity B-scan images. (C, H) Retinal cross-section details. (D, J) Phase retardation images (color scale: 0° – 180°). PS-OCT reveals polarization properties distinguishing the birefringent sclera and polarization scrambling only in the pigmented RPE and choroid of the Long Evans rat. (E, K) DOPU images (color scale: 0 – 1). Polarization scrambling in the RPE/choroid complex of the pigmented rat manifests in lower DOPU values (yellow, green). All scale bars in microns.

Fig. 5
Fig. 5

PM fiber based delay for polarization multiplexing. (A) A PM fiber patch cable was inserted in the sample illumination arm of the interferometer. (B) PM fibers have different refractive indices, n1 and n2, along their two polarization channels. (C) The refractive index difference causes a delay Δz between its orthogonal polarization channels. (D) The OCT signals originating from these two orthogonal incident states appear displaced by Δz = 0.97mm for a 5m long PM fiber in the sample arm. (E) Reflectivity B-scan image. (E) Phase retardation image.

Equations (7)

Equations on this page are rendered with MathJax. Learn more.

E meas 1 =( H 1 V 1 ), E meas 2 =( H 2 V 2 )
E in 1 =( 1 0 ), E in 2 =( 0 1 ).
E surf 1,2 = J out J in E in 1,2 .
E meas 1,2 = J out J sample J in E in 1,2 .
J meas =[ E meas 1 E meas 2 ]= J out J sample J in .
J sample U = J out J sample J out 1 = J meas J surf 1 .
DOPU= Q mean 2 + U mean 2 + V mean 2

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