Abstract

A large number of degrees of freedom are required to produce a high quality focus through random scattering media. Previous demonstrations based on spatial phase modulations suffer from either a slow speed or a small number of degrees of freedom. In this work, a high speed wavefront determination technique based on spatial frequency domain wavefront modulations is proposed and experimentally demonstrated, which is capable of providing both a high operation speed and a large number of degrees of freedom. The technique was employed to focus light through a strongly scattering medium and the entire wavefront was determined in 400 milliseconds, ~three orders of magnitude faster than the previous report.

© 2011 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
    [CrossRef] [PubMed]
  2. J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
    [CrossRef] [PubMed]
  3. W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
    [CrossRef] [PubMed]
  4. A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
    [CrossRef]
  5. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
    [CrossRef]
  6. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  7. E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
    [CrossRef] [PubMed]
  8. W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
    [CrossRef] [PubMed]
  9. T. Vo-Dinh, Biomedical photonics handbook (CRC press, New York, 2003).
  10. A. Yariv and P. Yeh, “Phase conjugate optics and real-time holography,” IEEE J. Quantum Electron. 14(9), 650–660 (1978).
    [CrossRef]
  11. C. Gu and P. C. Yeh, “Partial phase-conjugation, fidelity, and reciprocity,” Opt. Commun. 107(5-6), 353–357 (1994).
    [CrossRef]
  12. A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
    [CrossRef] [PubMed]
  13. M. Cui, E. J. McDowell, and C. H. Yang, “Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation,” Appl. Phys. Lett. 95(12), 123702 (2009).
    [CrossRef] [PubMed]
  14. M. Cui and C. Yang, “Implementation of a digital optical phase conjugation system and its application to study the robustness of turbidity suppression by phase conjugation,” Opt. Express 18(4), 3444–3455 (2010).
    [CrossRef] [PubMed]
  15. C. L. Hsieh, Y. Pu, R. Grange, and D. Psaltis, “Digital phase conjugation of second harmonic radiation emitted by nanoparticles in turbid media,” Opt. Express 18(12), 12283–12290 (2010).
    [CrossRef] [PubMed]
  16. G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
    [CrossRef] [PubMed]
  17. C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
    [CrossRef]
  18. A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. J. Hebert, and M. C. W. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
    [PubMed]
  19. D. Débarre, E. J. Botcherby, M. J. Booth, and T. Wilson, “Adaptive optics for structured illumination microscopy,” Opt. Express 16(13), 9290–9305 (2008).
    [CrossRef] [PubMed]
  20. M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
    [CrossRef] [PubMed]
  21. M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
    [CrossRef] [PubMed]
  22. N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
    [CrossRef]
  23. W. B. Bridges, P. T. Brunner, S. P. Lazzara, T. A. Nussmeier, T. R. O’Meara, J. A. Sanguinet, and W. P. Brown., “Coherent optical adaptive techniques,” Appl. Opt. 13(2), 291–300 (1974).
    [CrossRef] [PubMed]
  24. J. E. Pearson, W. B. Bridges, S. Hansen, T. A. Nussmeier, and M. E. Pedinoff, “Coherent optical adaptive techniques: design and performance of an 18-element visible multidither COAT system,” Appl. Opt. 15(3), 611–621 (1976).
    [CrossRef] [PubMed]
  25. I. M. Vellekoop and A. P. Mosk, “Focusing coherent light through opaque strongly scattering media,” Opt. Lett. 32(16), 2309–2311 (2007).
    [CrossRef] [PubMed]
  26. M. Cui, E. J. McDowell, and C. Yang, “An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear,” Opt. Express 18(1), 25–30 (2010).
    [CrossRef] [PubMed]
  27. I. M. Vellekoop and C. M. Aegerter, “Focusing light through living tissue,” Proc. SPIE 7554, 755430, 755430-10 (2010).
    [CrossRef]

2010

2009

M. Cui, E. J. McDowell, and C. H. Yang, “Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation,” Appl. Phys. Lett. 95(12), 123702 (2009).
[CrossRef] [PubMed]

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef]

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

2008

2007

I. M. Vellekoop and A. P. Mosk, “Focusing coherent light through opaque strongly scattering media,” Opt. Lett. 32(16), 2309–2311 (2007).
[CrossRef] [PubMed]

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

2006

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[CrossRef] [PubMed]

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

2004

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

2002

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. J. Hebert, and M. C. W. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
[PubMed]

1999

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[CrossRef]

1995

A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
[CrossRef] [PubMed]

1994

C. Gu and P. C. Yeh, “Partial phase-conjugation, fidelity, and reciprocity,” Opt. Commun. 107(5-6), 353–357 (1994).
[CrossRef]

1991

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

1990

W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[CrossRef] [PubMed]

1978

A. Yariv and P. Yeh, “Phase conjugate optics and real-time holography,” IEEE J. Quantum Electron. 14(9), 650–660 (1978).
[CrossRef]

1976

1974

Aegerter, C. M.

I. M. Vellekoop and C. M. Aegerter, “Focusing light through living tissue,” Proc. SPIE 7554, 755430, 755430-10 (2010).
[CrossRef]

Barclay, H. T.

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Betzig, E.

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[CrossRef]

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Bonifacino, J. S.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Booth, M. J.

D. Débarre, E. J. Botcherby, M. J. Booth, and T. Wilson, “Adaptive optics for structured illumination microscopy,” Opt. Express 16(13), 9290–9305 (2008).
[CrossRef] [PubMed]

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

Botcherby, E. J.

Bridges, W. B.

Brown, W. P.

Brunner, P. T.

Burns, L. D.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Campbell, M. C. W.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Cui, M.

Davidson, M. W.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

de Rosny, J.

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

Débarre, D.

Del Bene, F.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

Denk, W.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[CrossRef] [PubMed]

W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[CrossRef] [PubMed]

Derode, A.

A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
[CrossRef] [PubMed]

Donnelly Iii, W.

Fink, M.

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fraser, S. E.

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Ghosh, K. K.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Grange, R.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Gu, C.

C. Gu and P. C. Yeh, “Partial phase-conjugation, fidelity, and reciprocity,” Opt. Commun. 107(5-6), 353–357 (1994).
[CrossRef]

Hansen, S.

Hebert, T. J.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hess, H. F.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Holtom, G. R.

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[CrossRef]

Hsieh, C. L.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Huisken, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

Ji, N.

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[CrossRef]

Juskaitis, R.

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

Lazzara, S. P.

Lerosey, G.

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lindwasser, O. W.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Lippincott-Schwartz, J.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Mack-Bucher, J. A.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[CrossRef] [PubMed]

McDowell, E. J.

M. Cui, E. J. McDowell, and C. Yang, “An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear,” Opt. Express 18(1), 25–30 (2010).
[CrossRef] [PubMed]

M. Cui, E. J. McDowell, and C. H. Yang, “Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation,” Appl. Phys. Lett. 95(12), 123702 (2009).
[CrossRef] [PubMed]

McMahon, A.

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

Milkie, D. E.

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[CrossRef]

Mosk, A. P.

Mukamel, E. A.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Murphy, D. V.

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Neil, M. A. A.

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

Nussmeier, T. A.

O’Meara, T. R.

Olenych, S.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Page, D. A.

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Patterson, G. H.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Pearson, J. E.

Pedinoff, M. E.

Primmerman, C. A.

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Psaltis, D.

Pu, Y.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Queener, H.

Romero-Borja, F.

Roorda, A.

Roux, P.

A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
[CrossRef] [PubMed]

Rueckel, M.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[CrossRef] [PubMed]

Sanguinet, J. A.

Schnitzer, M. J.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sougrat, R.

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

Stathopoulos, A.

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

Stelzer, E. H. K.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Strickler, J. H.

W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[CrossRef] [PubMed]

Supatto, W.

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Swoger, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

Tourin, A.

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

Vellekoop, I. M.

I. M. Vellekoop and C. M. Aegerter, “Focusing light through living tissue,” Proc. SPIE 7554, 755430, 755430-10 (2010).
[CrossRef]

I. M. Vellekoop and A. P. Mosk, “Focusing coherent light through opaque strongly scattering media,” Opt. Lett. 32(16), 2309–2311 (2007).
[CrossRef] [PubMed]

Wang, L. V.

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef]

Webb, W. W.

W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[CrossRef] [PubMed]

Wei Ho, E. T.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Wilson, T.

D. Débarre, E. J. Botcherby, M. J. Booth, and T. Wilson, “Adaptive optics for structured illumination microscopy,” Opt. Express 16(13), 9290–9305 (2008).
[CrossRef] [PubMed]

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

Wilt, B. A.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Wittbrodt, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

Xie, X. S.

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[CrossRef]

Yang, C.

Yang, C. H.

M. Cui, E. J. McDowell, and C. H. Yang, “Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation,” Appl. Phys. Lett. 95(12), 123702 (2009).
[CrossRef] [PubMed]

Yariv, A.

A. Yariv and P. Yeh, “Phase conjugate optics and real-time holography,” IEEE J. Quantum Electron. 14(9), 650–660 (1978).
[CrossRef]

Yeh, P.

A. Yariv and P. Yeh, “Phase conjugate optics and real-time holography,” IEEE J. Quantum Electron. 14(9), 650–660 (1978).
[CrossRef]

Yeh, P. C.

C. Gu and P. C. Yeh, “Partial phase-conjugation, fidelity, and reciprocity,” Opt. Commun. 107(5-6), 353–357 (1994).
[CrossRef]

Zollars, B. G.

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Zumbusch, A.

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[CrossRef]

Annu. Rev. Neurosci.

B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci. 32(1), 435–506 (2009).
[CrossRef] [PubMed]

Appl. Opt.

Appl. Phys. Lett.

M. Cui, E. J. McDowell, and C. H. Yang, “Observation of polarization-gate based reconstruction quality improvement during the process of turbidity suppression by optical phase conjugation,” Appl. Phys. Lett. 95(12), 123702 (2009).
[CrossRef] [PubMed]

IEEE J. Quantum Electron.

A. Yariv and P. Yeh, “Phase conjugate optics and real-time holography,” IEEE J. Quantum Electron. 14(9), 650–660 (1978).
[CrossRef]

Nat. Methods

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[CrossRef]

Nat. Photonics

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef]

Nat. Protoc.

W. Supatto, A. McMahon, S. E. Fraser, and A. Stathopoulos, “Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis,” Nat. Protoc. 4(10), 1397–1412 (2009).
[CrossRef] [PubMed]

Nature

C. A. Primmerman, D. V. Murphy, D. A. Page, B. G. Zollars, and H. T. Barclay, “Compensation of atmospheric optical distortion using a synthetic beacon,” Nature 353(6340), 141–143 (1991).
[CrossRef]

Opt. Commun.

C. Gu and P. C. Yeh, “Partial phase-conjugation, fidelity, and reciprocity,” Opt. Commun. 107(5-6), 353–357 (1994).
[CrossRef]

Opt. Express

Opt. Lett.

Phys. Rev. Lett.

A. Derode, P. Roux, and M. Fink, “Robust acoustic time-reversal with high-order multiple-scattering,” Phys. Rev. Lett. 75(23), 4206–4209 (1995).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, “Three-dimensional vibrational imaging by coherent anti-stokes raman scattering,” Phys. Rev. Lett. 82(20), 4142–4145 (1999).
[CrossRef]

Proc. Natl. Acad. Sci. U.S.A.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[CrossRef] [PubMed]

M. J. Booth, M. A. A. Neil, R. Juskaitis, and T. Wilson, “Adaptive aberration correction in a confocal microscope,” Proc. Natl. Acad. Sci. U.S.A. 99(9), 5788–5792 (2002).
[CrossRef] [PubMed]

Proc. SPIE

I. M. Vellekoop and C. M. Aegerter, “Focusing light through living tissue,” Proc. SPIE 7554, 755430, 755430-10 (2010).
[CrossRef]

Science

G. Lerosey, J. de Rosny, A. Tourin, and M. Fink, “Focusing beyond the diffraction limit with far-field time reversal,” Science 315(5815), 1120–1122 (2007).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313(5793), 1642–1645 (2006).
[CrossRef] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[CrossRef] [PubMed]

W. Denk, J. H. Strickler, and W. W. Webb, “2-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[CrossRef] [PubMed]

Other

T. Vo-Dinh, Biomedical photonics handbook (CRC press, New York, 2003).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

Experiment setup. AOM1 and AOM2, acousto-optic modulators driven by 50MHz and 50.05MHz signals respectively; M, mirror; B, beam block; Relay, 4f relay lens pair; Fold, folding mirrors; CL, camera lens; 20x, NA 0.5 20x objective lens; 100x, NA 0.9 100x objective lens; Pinhole, 50 μm diameter pinhole.

Fig. 2
Fig. 2

Schematic illustration of the experiment. (a) The XY mirror beam and the SLM beam were beating at 50kHz. For every mode the XY mirrors visited in k space, the 50kHz signal from the target was analyzed to yield the phase and amplitude information. (b) At the end of the measurement, the information in k space was transformed to the spatial domain and the phase profile was displayed on the SLM to focus light onto the target.

Fig. 3
Fig. 3

(a) Raw data recorded during the experiment. Three signals were recorded: X mirror feedback signal, Y mirror feedback signal, and the photodiode signal (target signal). (b) The center area of (a). The 50 kHz oscillation can be clearly seen.

Fig. 4
Fig. 4

(a) The transmission intensity profile with wavefront compensation. (b) The compensation wavefront displayed on the SLM. (c) The transmission intensity profile without wavefront compensation.

Metrics