Abstract

A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

© 2009 Optical Society of America

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2008 (1)

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

2007 (2)

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

2006 (3)

Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006).
[CrossRef]

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
[CrossRef] [PubMed]

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

2005 (8)

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005).
[PubMed]

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005).
[CrossRef]

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

2004 (2)

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

2003 (2)

Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003).
[CrossRef] [PubMed]

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

2002 (2)

R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

2001 (2)

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

R. R. Raylman, "Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In," J. Nucl. Med. 42, 352-360 (2001).
[PubMed]

1999 (3)

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

1994 (1)

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Aretz, H. T.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Avril, N.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Barton, J. K.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Bonzom, S.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Boppart, S. A.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

Bouma, B. E.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

Brands, W. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Brewer, M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

Brewer, M. A.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Brezinski, M. E.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

Bristow, R. E.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Buck, A.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Burian, M.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Chak, A.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Charon, Y.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Chauhan, A.

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
[CrossRef] [PubMed]

Chen, Y.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

Cirocco, M.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Dadparvar, S.

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
[CrossRef] [PubMed]

Daghighian, F.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002).
[CrossRef] [PubMed]

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Das, A.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Davis, J. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Duval, A. A.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Escano, M. F.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Eshaghian, B.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Essner, R.

R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002).
[CrossRef] [PubMed]

Fisher, S. J.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Fishman, E. K.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Fong, Y.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Fujii, S.

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005).
[CrossRef]

Fujimoto, J. G.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Gardiner, G.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Ghazarossian, V.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

Giuliano, A. E.

R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002).
[CrossRef] [PubMed]

Giuntoli, R. L. N.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Gmitro, A. F.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Goodman, A.

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

Gordon, M. L.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Graeff, H.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Haber, G. B.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Halpern, E. F.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Hama, Y.

Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006).
[CrossRef]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hoffman, E. J.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Houser, S. L.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Hoyer, P. B.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

Hoying, J. B.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Humm, J.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Hunt, K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Isenberg, G.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Iwanczyk, J. S.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

Jana, S.

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
[CrossRef] [PubMed]

Janecek, M.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

Jang, I. K.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Jesser, C. A.

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

Jungbluth, A.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Kanamori, A.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Kandel, G.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Kang, D. H.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Kanter, E. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

Kauffman, C. R.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Kirkpatrick, N. D.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Kison, P. V.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Kortan, P.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Kuhn, W.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Kumar, R.

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
[CrossRef] [PubMed]

Larson, S. M.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Lederman, R. J.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Lefebvre, F.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Libus, J.

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

MacDonald, L.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

Maeda, H.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Marcon, N. E.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Marion, S. L.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

Matsumoto, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

Mazziotta, J. C.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Meisetschlager, G.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Menard, L.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Minato, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

Nabel, E. G.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Naehrig, J.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Nahrig, J.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Nakamoto, Y.

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005).
[CrossRef]

Nakamura, M.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Negi, A.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Old, L.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Palfi, S.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Pandit-Taskar, N.

N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005).
[PubMed]

Pannu, H. K.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Patt, B. E.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

Phelps, M. E.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Piao, D.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003).
[CrossRef] [PubMed]

Picchio, M.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Piert, M.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Pinot, L.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Pitre, S.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Pitris, C.

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
[CrossRef]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Qi, B.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Raylman, R. R.

R. R. Raylman, "Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In," J. Nucl. Med. 42, 352-360 (2001).
[PubMed]

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Rollins, A.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Rowland, D. Y.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Russo, P.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Rutke, S.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Sadeghi, M. M.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003).
[CrossRef] [PubMed]

Saga, T.

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005).
[CrossRef]

Sakamoto, S.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

San, H.

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Sassen, S.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Schlendorf, K. H.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Schmalfeldt, B.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Schulick, R. D.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Schwaiger, M.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Senda, M.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

Seya, R.

A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
[CrossRef]

Shenderov, P.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Shishkov, M.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Siebert, R.

S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
[CrossRef]

Siegel, S.

F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
[CrossRef] [PubMed]

Siewert, J. R.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Sinusas, A. J.

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003).
[CrossRef] [PubMed]

Sivak, M. V.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Stein, H. J.

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
[CrossRef] [PubMed]

Stevens, S. J.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Strong, V. E.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Tang, S. J.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Tarutani, K.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

Tearney, G. J.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
[PubMed]

Tornai, M. P.

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
[CrossRef] [PubMed]

Tsugita, R.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

Utzinger, U.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
[PubMed]

Vitkin, I. A.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Wahl, R. L.

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
[CrossRef] [PubMed]

Walker, R. M.

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

Weber, W. A.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

Werner, M.

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
[CrossRef] [PubMed]

William Strauss, H.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

Willis, J. E.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Wilson, B. C.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Wolf, B.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Wong, R. C.

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

Wong, W. D.

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

Yabushita, H.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
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Yamaguchi, Y.

M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
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Yamamoto, S.

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
[CrossRef] [PubMed]

Yang, V. X.

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
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D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
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D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
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Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, "Simultaneous optical coherence tomography imaging and beta particle detection," Opt. Lett. 28, 1704-1706 (2003).
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M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
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A. Kanamori, M. Nakamura, M. F. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Opthalmol. 135, 513-520 (2003).
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Ann. Nucl. Med. (1)

S. Yamamoto, K. Matsumoto, S. Sakamoto, K. Tarutani, K. Minato, and M. Senda, "An intra-operative positron probe with background rejection capability for FDG-guided surgery," Ann. Nucl. Med. 19, 23-28 (2005).
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Br. J. Obs. and Gyn. (1)

S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: Feasibility for laparoscopic-based imaging," Br. J. Obs. and Gyn. 106, 1071-1077 (1999).
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R. Essner, F. Daghighian, and A. E. Giuliano, "Advances in FDG pet probes in surgical oncology," Cancer J. 8, 100-108 (2002).
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Circulation (1)

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, G. J. Tearney "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
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Eur. J. Nucl. Med. (1)

E. J. Hoffman, M. P. Tornai, M. Janecek, B. E. Patt, and J. S. Iwanczyk, "Intraoperative probes and imaging probes," Eur. J. Nucl. Med. 26, 913-935 (1999).
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Eur. J. Nucl. Med. Mol. Imaging (1)

M. Piert, M. Burian, G. Meisetschlager, H. J. Stein, S. Ziegler, J. Nahrig, M. Picchio, A. Buck, J. R. Siewert, M. Schwaiger, "Positron detection for the intraoperative localisation of cancer deposits," Eur. J. Nucl. Med. Mol. Imaging 34, 1534-1544 (2007).
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Expert Rev. Anticancer Ther. (1)

R. Kumar, A. Chauhan, S. Jana, and S. Dadparvar, "Positron emission tomography in gynecological malignancies," Expert Rev. Anticancer Ther. 6, 1033-1044 (2006).
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Gastroint. Endosc. (2)

G. Isenberg, M. V. Sivak, A. Chak, R. C. Wong, J. E. Willis, B. Wolf, D. Y. Rowland, A. Das, A. Rollins, "Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: A prospective, double-blinded study," Gastroint. Endosc. 62, 825-831 (2005).
[CrossRef]

V. X. Yang, S. J. Tang, M. L. Gordon, B. Qi, G. Gardiner, M. Cirocco, P. Kortan, G. B. Haber, G. Kandel, I. A. Vitkin, B. C. Wilson, N. E. Marcon, "Endoscopic doppler optical coherence tomography in the human GI tract: Initial experience," Gastroint. Endosc. 61, 879-890 (2005).
[CrossRef]

Gynecol. Oncol. (1)

R. E. Bristow, R. L. N. Giuntoli, H. K. Pannu, R. D. Schulick, E. K. Fishman, and R. L. Wahl, "Combined PET/CT for detecting recurrent ovarian cancer limited to retroperitoneal lymph nodes," Gynecol. Oncol. 99, 294-300 (2005).
[CrossRef] [PubMed]

Heart (1)

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, "High resolution in vivo intra-arterial imaging with optical coherence tomography," Heart 82, 128-133 (1999).
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S. Bonzom, L. Menard, S. Pitre, A. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, "An intraoperative beta probe dedicated to glioma surgery: Design and feasibility study," IEEE T. Nucl. Sci. 54, 30-41 (2007).
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Intl. J. Clin. Oncol. (1)

Y. Hama, "Positron emission tomography with 18F-fluoro-2-deoxyglucose for the detection of recurrent ovarian cancer," Intl. J. Clin. Oncol. 11, 250-251 (2006).
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Intl. J. Gyn. Cancer (1)

Y. Nakamoto, T. Saga, and S. Fujii, "Positron emission tomography application for gynecologic tumors," Intl. J. Gyn. Cancer 15, 701-709 (2005).
[CrossRef]

J. Biomed. Opt. (2)

E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, "Dual modality imaging of a novel rat model of ovarian carcinogenesis," J. Biomed. Opt. 11, 041123 (2006).
[CrossRef] [PubMed]

D. Piao, M. M. Sadeghi, J. Zhang, Y. Chen, A. J. Sinusas, and Q. Zhu, "Hybrid positron detection and optical coherence tomography system: Design, calibration, and experimental validation with rabbit atherosclerotic models," J. Biomed. Opt. 10, 44010 (2005).
[CrossRef] [PubMed]

J. Clin. Oncol. (1)

N. Avril, S. Sassen, B. Schmalfeldt, J. Naehrig, S. Rutke, W. A. Weber, M. Werner, H. Graeff, M. Schwaiger, W. Kuhn, "Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer," J. Clin. Oncol. 23, 7445-7453 (2005).
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N. Pandit-Taskar, "Oncologic imaging in gynecologic malignancies," J. Nucl. Med. 46, 1842-1850 (2005).
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F. Daghighian, J. C. Mazziotta, E. J. Hoffman, P. Shenderov, B. Eshaghian, S. Siegel, M. E. Phelps, "Intraoperative beta probe: A device for detecting tissue labeled with positron or electron emitting isotopes during surgery," Med. Phys. 21, 153-157 (1994).
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M. Janecek, B. E. Patt, J. S. Iwanczyk, L. MacDonald, Y. Yamaguchi, H. William Strauss, R. Tsugita, V. Ghazarossian, E. J. Hoffman, "Intravascular probe for detection of vulnerable plaque," Mol. Imaging Biol. 6, 131-138 (2004).
[CrossRef] [PubMed]

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R. J. Lederman, R. R. Raylman, S. J. Fisher, P. V. Kison, H. San, E. G. Nabel, R. L. Wahl, "Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG)," Nucl. Med. Commun. 22, 747-753 (2001).
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Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
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Surg. Endosc. (1)

V. E. Strong, J. Humm, P. Russo, A. Jungbluth, W. D. Wong, F. Daghighian, L. Old, Y. Fong, S. M. Larson, "A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes," Surg. Endosc. 22, 386-391 (2008).
[CrossRef]

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M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, A. F. Gmitro, "Imaging of the ovary," Technol. Cancer Res.Treat. 3, 617-627 (2004).
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S. R. Cherry, J. Sorenson, and M. E. Phelps, Physics in Nuclear Medicine, Third Edition, (Saunders, 2003). Saunders.

H. Tan, W. Hennig, Y. Chu, M. Momayezi, and W. Warburton, "Extending the operation of a position-sensitive photomultiplier tube to 1 million counts per second," Nucl. Inst. Meth. Phys. Res. (2007).

S. A. Gulec, F. Daghighian, and R. Essner, "PET-probe: Evaluation of technical performance and clinical utility of a handheld high-energy gamma probe in oncologic surgery," Ann. Surg. Oncol. (2006).
[CrossRef] [PubMed]

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Figures (9)

Fig. 1.
Fig. 1.

The prototype hybrid intraoperative probe system. (a) The single-mode OCT fiber is translated and rotated from the proximal end of the catheter and pulled out gradually during the scanning. (b) Tissue surface view of probe illustrating location and spacing of 1mm scintillating fiber tips alongside the central OCT slot. (c) Photograph of system.

Fig. 2.
Fig. 2.

(a). Swept-source Fourier-Domain OCT system. (b) Ex vivo OCT image of human ovary epithelium. Comparing the OCT image with the histology, we see inclusion cysts (cysts in ovarian surface epithelium) about 200 μm deep (white arrows). Adjacent, we see the edge of a follicle (blue arrow) about 400–600 μm deep. Higher intensity regions indicate rich collagen content (red arrows) [26].

Fig. 3.
Fig. 3.

Block diagram of detection circuitry. The position sensitivity PMT and front end Anger-logic electronics are housed in a shielded box to reduce electromagnetic interference and stray light.

Fig. 4.
Fig. 4.

Representative detector responses for (a) longitudinal and (b) lateral scans of a 1mm Tl204 source. Error bars denote standard deviations for eight 30-second measurements.

Fig. 5.
Fig. 5.

Centroid estimated position vs. true position for a scanned Tl204 beta source. (a) Scan along longitudinal direction. The rows are spaced 1.5 mm in the lateral dimension with the first and fourth rows corresponding to the two rows of scintillator detector tips. The plots demonstrate the excellent longitudinal position determination within the 3 to 9 mm range of the tips achieved for all lateral positions. (b) Scan along the lateral direction. The columns were spaced 0.8 mm apart with the first and third coinciding with opposing sets of detectors across the OCT channel. The small spatial overlap of the detector responses in this dimension currently permits only localization to either side of the OCT channel. Error bars denote standard deviations for eight 30-second measurements.

Fig. 6.
Fig. 6.

Raw (a) and gamma subtracted (b) counts for a 1.5 mm diameter Tl204 source scanned in the longitudinal direction. Centroid position determination vs. true position (c) using gamma-subtracted data set and raw data sets. Error bars denote standard deviations for eight 30-second measurements.

Fig. 7.
Fig. 7.

Centroid-estimated source position for a 3 mm 18F-FDG hemispherical source scanned along the longitudinal probe axis beneath the scintillator probe tips and displaced 1.5 mm laterally toward the OCT center. Error bars denote standard deviations for four 15-second measurements. The individual fibers are located at 3.0, 4.75,6.5, and 8.25 mm.

Fig. 8.
Fig. 8.

Measured counts in each probe detection fiber and corresponding sector-scan OCT images at three locations spanning 1 mm demonstrating co-registered localization and imaging.

Fig. 9.
Fig. 9.

OCT fiber with integrated angled lens: (a) Photograph and (b) Image of porcine ovary epithelium obtained with probe. The white arrows indicate ovarian follicles.

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