Abstract

An all optical method for dielectric Rayleigh particle sorting possesses significant advantages. Here, we describe an approach that applies optical scattering forces to translate varied sized particles differentially from a surface followed by the introduction of an optical standing wave to maintain and tighten the positional tolerance of the differentiated particles in the medium. Numerical simulation demonstrates the workability of this scheme; which is highly dependent on Brownian forces typically dominant at this length scale. It also shows the significant impact of temperature and medium viscosity on the operation of this technique.

© 2009 Optical Society of America

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  1. A. R. Todeschini, J. N. Dos Santos, K. Handa, and S. Hakomori, "Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway," Proc. Nat. Acad. Sci. 105, 1925-1930 (2008).
    [CrossRef] [PubMed]
  2. A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
    [CrossRef]
  3. A. Jaworek, "Micro- and nanoparticle production by electrospraying," Powder Technol. 176, 18-35 (2007).
    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
  12. R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
    [CrossRef]
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  16. J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
    [CrossRef] [PubMed]
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    [CrossRef]
  18. A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).
  19. A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
    [CrossRef]
  20. Y. Harada and T. Asakura, "Radiation forces on dielectric sphere in the Rayleigh scattering regime," Opt. Commun. 124, 529-541 (1996).
    [CrossRef]
  21. S. Abuzeid, A. A. Busnaina, and G. Ahmadi, "Wall Deposition of Aerosol particles in a Turbulent Channel Flow," J. Aerosol Sci. 22, 43-62 (1991).
    [CrossRef]
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  24. H. A. Kramers, "Brownian motion in a field of force and the diffusion model of chemical reactions," Physica 7, 284-360 (1940).
    [CrossRef]
  25. P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
    [CrossRef]

2008

2007

Y. Zhao, B. S. Fujimoto, G. D. Jeffries, P. G. Schiro, and D. T. Chiu, "Optical gradient flow focusing," Opt. Express 15, 6167-6176 (2007).
[CrossRef] [PubMed]

A. Jaworek, "Micro- and nanoparticle production by electrospraying," Powder Technol. 176, 18-35 (2007).
[CrossRef]

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
[CrossRef]

2006

2005

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
[CrossRef]

2004

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

R. W. Applegate, J. Squier, T. Vestad, J. Oakey, and D. W. Marr, "Optical trapping, manipulation, and sorting of cells and colloids in microfluidic systems with diode laser bars," Opt. Express 12, 4390-4398 (2004).
[CrossRef] [PubMed]

2003

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

M. P. MacDonald, G. C. Spalding, and K. Dholakia, "Microfluidic sorting in an optical lattice" Nature 426, 421-424 (2003).
[CrossRef] [PubMed]

1998

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

1996

Y. Harada and T. Asakura, "Radiation forces on dielectric sphere in the Rayleigh scattering regime," Opt. Commun. 124, 529-541 (1996).
[CrossRef]

1995

T. Imasaka, Y. Kawabata, T. Kaneta, and I. Ishidzu, "Optical chromatography," Anal. Chem. 67, 1763-1765 (1995).
[CrossRef]

1991

S. Abuzeid, A. A. Busnaina, and G. Ahmadi, "Wall Deposition of Aerosol particles in a Turbulent Channel Flow," J. Aerosol Sci. 22, 43-62 (1991).
[CrossRef]

1940

H. A. Kramers, "Brownian motion in a field of force and the diffusion model of chemical reactions," Physica 7, 284-360 (1940).
[CrossRef]

1866

J. C. Maxwell, "On the viscosity of internal friction of air and other gasses," Philos. Trans. R. Soc. London 156, 249-268 (1866).
[CrossRef]

Abuzeid, S.

S. Abuzeid, A. A. Busnaina, and G. Ahmadi, "Wall Deposition of Aerosol particles in a Turbulent Channel Flow," J. Aerosol Sci. 22, 43-62 (1991).
[CrossRef]

Ahmadi, G.

S. Abuzeid, A. A. Busnaina, and G. Ahmadi, "Wall Deposition of Aerosol particles in a Turbulent Channel Flow," J. Aerosol Sci. 22, 43-62 (1991).
[CrossRef]

Ananthakrishnan, R.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Applegate, R. W.

Asakura, T.

Y. Harada and T. Asakura, "Radiation forces on dielectric sphere in the Rayleigh scattering regime," Opt. Commun. 124, 529-541 (1996).
[CrossRef]

Badenes, G.

Bilby, C.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Bryant, P. E.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Bu, J.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

Burnham, D. R.

Busnaina, A. A.

S. Abuzeid, A. A. Busnaina, and G. Ahmadi, "Wall Deposition of Aerosol particles in a Turbulent Channel Flow," J. Aerosol Sci. 22, 43-62 (1991).
[CrossRef]

Butler, W. F.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Chiu, D. T.

Cizmar, T.

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

Dees, B.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Dholakia, K.

R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

M. P. MacDonald, G. C. Spalding, and K. Dholakia, "Microfluidic sorting in an optical lattice" Nature 426, 421-424 (2003).
[CrossRef] [PubMed]

Dos Santos, J. N.

A. R. Todeschini, J. N. Dos Santos, K. Handa, and S. Hakomori, "Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway," Proc. Nat. Acad. Sci. 105, 1925-1930 (2008).
[CrossRef] [PubMed]

Dual, J.

A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
[CrossRef]

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

Ebert, S.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Erickson, H. M.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Forster, A. H.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Fujimoto, B. S.

Garces-Chavez, V.

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

Giersig, M.

A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
[CrossRef]

Glaczynska, H.

A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
[CrossRef]

Grzegorczyk, T. M.

Guck, J.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Gunn-Moore, F. J.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Hagen, N.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Hakomori, S.

A. R. Todeschini, J. N. Dos Santos, K. Handa, and S. Hakomori, "Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway," Proc. Nat. Acad. Sci. 105, 1925-1930 (2008).
[CrossRef] [PubMed]

Handa, K.

A. R. Todeschini, J. N. Dos Santos, K. Handa, and S. Hakomori, "Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway," Proc. Nat. Acad. Sci. 105, 1925-1930 (2008).
[CrossRef] [PubMed]

Harada, Y.

Y. Harada and T. Asakura, "Radiation forces on dielectric sphere in the Rayleigh scattering regime," Opt. Commun. 124, 529-541 (1996).
[CrossRef]

Heeramann, P.

Imasaka, T.

T. Imasaka, Y. Kawabata, T. Kaneta, and I. Ishidzu, "Optical chromatography," Anal. Chem. 67, 1763-1765 (1995).
[CrossRef]

Ishidzu, I.

T. Imasaka, Y. Kawabata, T. Kaneta, and I. Ishidzu, "Optical chromatography," Anal. Chem. 67, 1763-1765 (1995).
[CrossRef]

Jákl, P.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Jaworek, A.

A. Jaworek, "Micro- and nanoparticle production by electrospraying," Powder Technol. 176, 18-35 (2007).
[CrossRef]

Jeffries, G. D.

Ježek, J.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Jonas, A.

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

Jonáš, A.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Kandulski, W.

A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
[CrossRef]

Kaneta, T.

T. Imasaka, Y. Kawabata, T. Kaneta, and I. Ishidzu, "Optical chromatography," Anal. Chem. 67, 1763-1765 (1995).
[CrossRef]

Kariv, I.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Käs, J.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Kawabata, Y.

T. Imasaka, Y. Kawabata, T. Kaneta, and I. Ishidzu, "Optical chromatography," Anal. Chem. 67, 1763-1765 (1995).
[CrossRef]

Kemp, B. A.

Kong, J. A.

Kosiorek, A.

A. Kosiorek, W. Kandulski, H. Glaczynska, and M. Giersig, "Fabrication of nanoscale rings, dots, and rods by combining shadow nanosphere lithography and annealed polystyrene nanosphere masks," Small 1, 439-444 (2005).
[CrossRef]

Kramers, H. A.

H. A. Kramers, "Brownian motion in a field of force and the diffusion model of chemical reactions," Physica 7, 284-360 (1940).
[CrossRef]

Lenz, D.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Lincoln, B.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Liska, M.

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

Liška, M.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Liu, R.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

MacDonald, M. P.

R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

M. P. MacDonald, G. C. Spalding, and K. Dholakia, "Microfluidic sorting in an optical lattice" Nature 426, 421-424 (2003).
[CrossRef] [PubMed]

Marchand, P. J.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Marr, D. W.

Maxwell, J. C.

J. C. Maxwell, "On the viscosity of internal friction of air and other gasses," Philos. Trans. R. Soc. London 156, 249-268 (1866).
[CrossRef]

McGloin, D.

Mercer, E. M.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Milne, G.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Mitchell, D.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

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T. W. Ng, A. Neild, and P. Heeramann, "Continuous sorting of Brownian particles using coupled photophoresis and asymmetric potential cycling," Opt. Lett. 33, 584-586 (2008).
[CrossRef] [PubMed]

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
[CrossRef]

Ng, T. W.

Nieto-Vesperinas, M.

Oakey, J.

Oberti, S.

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
[CrossRef]

Ong, L. S.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

Papagiakoumou, E.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

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L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Quidant, R.

Radziwill, G.

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

Raymond, D. E.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Riches, A. C.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Romeyke, M.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Schinkinger, S.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Schiro, P. G.

Sery, M.

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

Šery, M.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Sibbett, W.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Siler, M.

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

Smith, R. L.

R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

Spalding, G. C.

R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

M. P. MacDonald, G. C. Spalding, and K. Dholakia, "Microfluidic sorting in an optical lattice" Nature 426, 421-424 (2003).
[CrossRef] [PubMed]

Squier, J.

Sramek, L.

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

Summers, M. D.

Sun, Y. Y.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

Tatarkova, S. A.

L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Todeschini, A. R.

A. R. Todeschini, J. N. Dos Santos, K. Handa, and S. Hakomori, "Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway," Proc. Nat. Acad. Sci. 105, 1925-1930 (2008).
[CrossRef] [PubMed]

Tu, E.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Ulvickand, S.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

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Wang, M. M.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Wottawah, F.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Yang, J. M.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Yuan, X. C.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

Zelenina, A. S.

Zemanek, P.

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
[CrossRef]

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

Zemánek, P.

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
[CrossRef]

Zhang, H.

M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Zhao, Y.

Zhu, S. W.

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
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L. Paterson, E. Papagiakoumou, G. Milne, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, K. Dholakia, "Light induced cell separation in a tailored optical landscape," Appl. Phys. Lett. 87, 123901 (2005).
[CrossRef]

Y. Y. Sun, X. C. Yuan, L. S. Ong, J. Bu, S. W. Zhu, and R. Liu, "Large-scale optical traps on a chip for optical sorting" Appl. Phys. Lett. 90, 031107 (2007).
[CrossRef]

Biophys. J.

J. Guck, S. Schinkinger, B. Lincoln, F. Wottawah, S. Ebert, M. Romeyke, D. Lenz, H. M. Erickson, R. Ananthakrishnan, D. Mitchell, J. Käs, S. Ulvickand, and C. Bilby, "Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic Competence," Biophys. J. 88, 3689-3698 (2005).
[CrossRef] [PubMed]

Biotechnol. Bioeng.

A. Neild, S. Oberti, G. Radziwill, and J. Dual, "Simultaneous Positioning of Cells into Two-Dimensional Arrays using Ultrasound," Biotechnol. Bioeng. 92, 8-14 (2007).

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R. L. Smith, G. C. Spalding, K. Dholakia, and M. P. MacDonald, "Colloidal sorting in dynamic optical lattices," J. Opt. A, Pure Appl. Opt. 9, S134-S138 (2007).
[CrossRef]

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M. M. Wang, E. Tu, D. E. Raymond, J. M. Yang, H. Zhang, N. Hagen, B. Dees, E. M. Mercer, A. H. Forster, I. Kariv, P. J. Marchand, and W. F. Butler, "Microfluidic sorting of mammalian cells by optical force switching," Nat. Biotechnol. 23, 83-87 (2004).
[CrossRef] [PubMed]

Nature

M. P. MacDonald, G. C. Spalding, and K. Dholakia, "Microfluidic sorting in an optical lattice" Nature 426, 421-424 (2003).
[CrossRef] [PubMed]

Opt. Commun.

P. Zemanek, A. Jonas, L. Sramek, and M. Liska, "Optical trapping of Rayleigh particles using a Gaussian standing wave," Opt. Commun. 151, 273-285 (1998).
[CrossRef]

P. Zemánek, A. Jonáš, P. Jákl, J. Ježek, M. Šery, and M. Liška, "Theoretical comparison of optical traps created by standing wave and single beam," Opt. Commun. 220, 401-412 (2003).
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[CrossRef]

Phys. Rev. B

T. Cizmar, M. Siler, M. Sery, P. Zemanek, V. Garces-Chavez, and K. Dholakia, "Optical sorting and detection of submicrometer objects in a motional standing wave," Phys. Rev. B 74, 035105 (2006).
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A. Neild, S. Oberti, and J. Dual, "Design, modeling and characterization of microfluidic devices for ultrasonic manipulation," Sens. Actuators B 121, 452-461 (2007).
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Figures (6)

Fig. 1.
Fig. 1.

Schematic description of the proposed optical sorting geometry that comprises laser beam 1 for predominant scattering and laser beam 2 for trapping in which an optical filter allows a seamless operation of both (A). A monolayer of particles with different sizes (B) is scattered upwards under the action of laser scattering such that larger particles are dispersed further from the surface (C). Introduction of the standing wave laser trap at the right moment ensures that the differentiated size particles are spatially maintained (D).

Fig. 2.
Fig. 2.

Line plots of the optical (a) travelling – axial, (b) travelling – radial, (c) standing – axial, and (b) standing – radial forces acting on a 30nm radius particle.

Fig. 3.
Fig. 3.

(a). Axial location distribution of the 90, 50 and 10% distributions of 24, 27 and 20 nm particles at 200K subjected to optical travelling wave, and (b) scatter plot of position distribution in axial and radial sense after 0.03s.

Fig. 4.
Fig. 4.

(a). Axial location distribution of the 90, 50 and 10% distributions of 24, 27 and 20 nm particles at 200K subjected to optical travelling wave for 0.015s followed by optical standing wave, and (b) scatter plot of position distribution in axial and radial sense after 0.03s.

Fig. 5.
Fig. 5.

(a). Axial location distribution of the 90, 50 and 10% distributions of 24, 27 and 30 nm particles subjected to optical travelling wave for 0.015s followed by optical standing wave at 293 K, and (b) the same distributions at 100 K.

Fig. 6.
Fig. 6.

Distribution profiles of each particle size (blue: 24 μm, green: 27 μm and red: 30 μm) after 0.03 seconds. The profiles have been found by counting the number of particles in each 0.1 μm step moved in the axial direction. The temperatures of the simulations shown are (a) 100 K, (b) 200 K, (c) 293 K.

Tables (2)

Tables Icon

Table 1. The axial location of the 30 nm particles after 0.015 s exposure to traveling wave forces and Brownian motion.

Tables Icon

Table 2. The percentage of each particle size in zones defined in the axial direction. Each zone size (as listed in the table) has been selected to maximize the sorting between particles. The sorting is characterized in this manner for 3 particles sizes (100 K and 200 K) at lower temperatures and 2 particle sizes (200 K and 293 K) for higher temperatures.

Equations (10)

Equations on this page are rendered with MathJax. Learn more.

Fz scat _ tw = z ̂ n 2 c 16 3 k tw 4 a 6 P m 2 A exp [ 2 r 2 A ]
Fz grad _ tw = z ̂ 32 n 2 a 3 c Pm z A k tw 2 w tw 4 + z 2 ( 1 2 r 2 A ) exp [ 2 r 2 A ]
A = k tw 2 w tw 2 k tw 2 w tw 4 + 4 z 2
Fr grad _ tw = r ̂ 8 n 2 a 3 c Pm r A 2 exp [ 2 r 2 A ]
Fz grad _ sw = z ̂ 16 n 2 a 3 c P m k sw B exp [ 2 r 2 B ] sin ( ϕ )
Fr grad _ sw = r ̂ 16 n 2 a 3 c Pm r B 2 ( 2 + 2 cos ϕ + 4 z k sw w sw 2 sin ϕ ) exp [ 2 r 2 B ]
ϕ = 2 k sw z + 4 z k sw r 2 k sw 2 w sw 4 + 4 z 2 2 tan 1 ( 2 z k sw w sw 2 ) + ψ
B = k sw 2 w sw 2 k sw 2 w sw 4 + 4 z 2
M d 2 i d t 2 + F opt ( i ̂ ) + β di dt + 2 βkT ξ = 0
Δ z = 2 kT Δ t β ξ

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