Abstract

Ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) and speckle noise-reduced SD-OCT instruments were compared with regard to their ability to visualize retinal microstructures and detect micropathologies in the same series of eyes in this hospital-based study. Both the instruments identically visualized normal retinal structures, except for the retinal ganglion cell layer, which was better delineated by the speckle noise-reduced SD-OCT instrument. Retinal pigment epithelium (RPE) and Bruch’s membrane were better delineated by UHR SD-OCT. Retinal and sub-RPE pathologies were also identically visualized by both the instruments. Layer differentiation for locating each pathology was better visualized by speckle noise-reduced SD-OCT.

© 2009 Optical Society of America

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Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

2008

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

2006

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

2005

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

B. Sander, M. Larsen, L. Thrane L, J. L. Hougaard, and T. M. Jorgensen, "Enhanced optical coherence tomography imaging by multiple scan averaging," Br. J. Ophthalmol. 89, 207-212 (2005).
[CrossRef] [PubMed]

2004

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In-vivo human retinal imaging by ultra high-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-482 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

2003

2002

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

2001

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Adler, D.C.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Bajraszewski, T.

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Baumal, C.

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

Baumal, C. R.

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Bilonick, R. A.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

Bouma, B. E.

Bouma, B.E.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Cense, B.

Chan, A.

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Chen, R.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

Chen, T. C.

Chen, T.C.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Choma, M. A.

de Boer, J. F.

de Boer, J.F.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Drexler, W.

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Duker, J. S.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Ergun, E.

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

Fercher, A. F.

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Findl, O.

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Fujimoto, JG.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Ghanta, R. K.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Gorczynska, I.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Hangai, M.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Hartl, I.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Hitzenberger, C. K.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Ishikawa, H.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

Izatt, J. A.

Kärtner, F. X.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Ko, T. H.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Ko, T.H.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Kowalczyk, A.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Kowalevicz, A. M.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

Larsen, M.

B. Sander, M. Larsen, L. Thrane L, J. L. Hougaard, and T. M. Jorgensen, "Enhanced optical coherence tomography imaging by multiple scan averaging," Br. J. Ophthalmol. 89, 207-212 (2005).
[CrossRef] [PubMed]

Leitgeb, R.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Leitgeb, R. A.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Mamedov, D.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Michels, S.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005).
[CrossRef] [PubMed]

Monson, B. K.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

Morgner, U.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Nassif, N.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In-vivo human retinal imaging by ultra high-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-482 (2004).
[CrossRef] [PubMed]

Ojima, Y.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Otani, A.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Park, B. H.

Park, B.H.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Paunescu, L. A.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Pierce, M. C.

Pierce, M.C.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Prokhorov, V.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Puliafito, C. A.

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Reichel, E.

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Rogers, A. H.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Sakamoto, A.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Sander, B.

B. Sander, M. Larsen, L. Thrane L, J. L. Hougaard, and T. M. Jorgensen, "Enhanced optical coherence tomography imaging by multiple scan averaging," Br. J. Ophthalmol. 89, 207-212 (2005).
[CrossRef] [PubMed]

Sarunic, M. V.

Sattmann, H.

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Schmidt-Erfurth, U.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005).
[CrossRef] [PubMed]

Schocket, L. S.

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

Scholda, C.

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Schuman, J. S.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Shidlovski, V.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V. J.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Stur, M.

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Tamura, H.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Targowski, P.

Tearney, G. J.

Tearney, G.J.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Tsujikawa, A.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Unterhuber, A.

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

White, B.R.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Wirtitsch, M.

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Wirtitsch, M. G.

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

Witkin, A. J.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

Wojtkowski, M.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Wollstein, G.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

Yakubovich, S.

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Yang, C.

Yoshimura, N.

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Yun, S. H.

Yun, S.H.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Am. J. Ophthalmol.

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140,976-983 (2005).
[CrossRef] [PubMed]

Arch. Ophthalmol.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

T. H. Ko, A. J. Witkin, J. G. Fujimoto, A. Chan, A. H. Rogers, C. R. Baumal, J. S. Schuman, W. Drexler, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

Br. J. Ophthalmol.

B. Sander, M. Larsen, L. Thrane L, J. L. Hougaard, and T. M. Jorgensen, "Enhanced optical coherence tomography imaging by multiple scan averaging," Br. J. Ophthalmol. 89, 207-212 (2005).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49,1571-1579 (2008).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt’s disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 46,310-316 (2005).
[CrossRef]

J. Biomed. Opt.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Nat. Med.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001).
[CrossRef] [PubMed]

Ophthalmology

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 2033-2043 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. Kowalczyk, J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study," Ophthalmology 113,388-397 (2006).
[CrossRef] [PubMed]

L. S. Schocket, A. J. Witkin, J. G. Fujimoto, T. H. Ko, J. S. Schuman, A. H. Rogers, C. Baumal, E. Reichel, and J. S. Duker, "Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair," Ophthalmology 113,666-672 (2006).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Optics Express

T.H. Ko, D.C. Adler, JG. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, "Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source," Optics Express 12,2112-2119 (2004).
[CrossRef] [PubMed]

Retina

Y. Ojima, M. Hangai, A. Sakamoto, A. Tsujikawa, A. Otani, H. Tamura, and N. Yoshimura, "Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography," Retina 29,52-59 (2009).
[CrossRef]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Other

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology  113,2054-2065.e3 (2006).
[CrossRef] [PubMed]

A. Sakamoto, M. Hangai, and N. Yoshimura, "Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases," Ophthalmology 115,1071-1078.e7 (2008).
[CrossRef]

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Figures (5)

Fig. 1.
Fig. 1.

B-scan images of a normal eye, obtained by SOCT Copernicus HR (a, b), an ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) instrument and the Spectralis™ HRA+OCT, which can produce speckle-noise-reduced SD-OCT images (c, d). a, A single B-scan image developed from 10,610 axial scans; b, a single B-scan image developed from 1,516 axial scans; c, a speckle-noise-reduced image produced from 50 B-scans, each of which was developed from 1,536 axial scans; d, a single B-scan image developed from 1,536 axial scans. RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; ELM, external limiting membrane; IS/OS, photoreceptor inner and outer segment junction; COST, cone outer segment tip; ROST, rod outer segment tip; RPE, retinal pigment epithelium; BM, Bruch’s membrane. The retinal microstructures are almost identically visualized in both the images. The boundaries of each layer, especially the demarcation between GCL and IPL (arrowheads), are better differentiated by speckle-noise-reduced SD-OCT. RPE and Bruch’s membrane are better resolved by UHR SD-OCT.

Fig. 2.
Fig. 2.

B-scan images obtained by performing UHR SD-OCT (a) and speckle-noise-reduced SD-OCT (b) in a 72-year-old man who presented with branch retinal vein occlusion in the left eye with symptoms for 5 months. The best-corrected visual acuity was 20/50 in the left eye. There are a number of hard exudates within the intraretinal layers. It was easy to locate the hard exudates by speckle noise-reduced SD-OCT, probably because of the high contrast between the layers.

Fig. 3.
Fig. 3.

B-scan images obtained by performing UHR SD-OCT (a) and speckle-noise-reduced SDOCT (b) in the right eye of a 55-year-old man with central serous chorioretinopathy. The patient was diagnosed with diabetic retinopathy, and pan-retinal photocoagulation was performed in both eyes. During the follow-up, he patient experienced a decrease in vision and exhibited metamorphopsia in the right eye. The best-corrected visual acuity was decreased to 20/32 in the left eye. ELM, external limiting membrane; IS/OS, photoreceptor inner and outer segment junction; COST, cone outer segment tip; RPE, retinal pigment epithelium; BM, Bruch’s membrane. The two lines representing the IS/OS and the interdigitation of the cone photoreceptor outer segments and the RPE (COST) are invisible in the elevated retina due to serous retinal detachment. In contrast, the ELM line is clearly visible in the elevated retina. Thus, the two highly reflective lines in the photoreceptor layer of the attached and elevated retina were identically visualized by both the instruments.

Fig. 4.
Fig. 4.

B-scan images obtained by performing UHR SD-OCT (a) and speckle-noise-reduced SDOCT (b) in the left eye of a 68-year-old man with retinitis pigmentosa in both eyes. He was diagnosed with retinitis pigmentosa 12 years before. The best-corrected visual acuity in both eyes was 20/25. ELM, external limiting membrane; IS/OS, photoreceptor inner and outer segment junction; COST, cone outer segment tip; RPE, retinal pigment epithelium; BM, Bruch’s membrane. The asterisks indicate cystoid spaces. The three highly reflective lines representing the ELM, IS/OS, and COST indicate the region where the photoreceptor layer is preserved. The three preserved lines are identically visualized in both the images.

Fig. 5.
Fig. 5.

B-scan images obtained by performing UHR SD-OCT (a) and speckle-noise-reduced SDOCT (b) in a 65-year-old man with polypoidal choroidal vasculopathy, a peculiar form of exudative age-related macular degeneration. The patient had received photodynamic therapy in his left eye 1 year before, in another hospital. However, one week before the initial visit to our hospital, he experienced a decrease in vision and metamorphopsia recurred in the left eye, and he was referred to our hospital. The best-corrected visual acuity was 20/50 in the left eye. Layers are labeled as follows: ELM, external limiting membrane; IS/OS, photoreceptor inner and outer segment junction; RPE, retinal pigment epithelium; BM, Bruch’s membrane; CNV, choroidal neovascularization. An asterisk indicates a polypoidal lesion and two asterisks indicate a branching vascular network. The highly reflective straight line representing the BM is depicted clearly beneath the undulating RPE line in both the instruments. Moderately reflective lesions representing the CNV are similarly seen delineated in both instruments between the undulating RPE and the Bruch’s membrane line.

Tables (1)

Tables Icon

Table 1. Comparison of the imaging of each retinal pathology between the 2 instruments

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