Abstract

The objective of this work is to establish an optical imaging technique that would enable monitoring of the integration of mesenchymal stem cells (MSC) in arthritic joints. Our approach is based on first developing a labeling technique of MSC with the fluorescent dye DiD followed by tracking the cell migration kinetics from the spatial distribution of the DiD fluorescence in optical images (OI). The experimental approach involves first the in vitro OI of MSC labeled with DiD accompanied by fluorescence microscopy measurements to establish localization of the signal within the cells. Thereafter, DiD-labeled MSC were injected into polyarthritic, athymic rats and the signal localization within the experimental animals was monitored over several days. The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints.

© 2009 OSA

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    [CrossRef]
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    [CrossRef]
  35. G. M. Smythe, S. I. Hodgetts, and M. D. Grounds, “Immunobiology and the future of myoblast transfer therapy,” Mol. Ther. 1(4), 304–313 (2000).
    [CrossRef]
  36. O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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    [CrossRef]
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    [CrossRef]
  39. B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” J. Biomed. Opt. 6(4), 432–440 (2001).
    [CrossRef]
  40. R. Weissleder and V. Ntziachristos, “Shedding light onto live molecular targets,” Nat. Med. 9(1), 123–128 (2003).
    [CrossRef]

2008 (2)

E. J. Sutton, T. D. Henning, B. J. Pichler, C. Bremer, and H. E. Daldrup-Link, “Cell tracking with optical imaging,” Eur. Radiol. 18(10), 2021–2032 (2008).
[CrossRef]

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
[CrossRef]

2007 (1)

S. Biswal, D. L. Resnick, J. M. Hoffman, and S. S. Gambhir, “Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice,” Radiology 244(3), 651–671 (2007).
[CrossRef]

2006 (4)

G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
[CrossRef]

V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
[CrossRef]

B. N. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, “The fluorescent toolbox for assessing protein location and function,” Science 312(5771), 217–224 (2006).
[CrossRef]

O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
[CrossRef]

2005 (5)

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

V. Gangji, M. Toungouz, and J. P. Hauzeur, “Stem cell therapy for osteonecrosis of the femoral head,” Expert Opin. Biol. Ther. 5(4), 437–442 (2005).
[CrossRef]

T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
[CrossRef]

J. J. Mao, “Stem-cell-driven regeneration of synovial joints,” Biol. Cell 97(5), 289–301 (2005).
[CrossRef]

M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
[CrossRef]

2004 (5)

A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
[CrossRef]

C. Jorgensen, J. Gordeladze, and D. Noel, “Tissue engineering through autologous mesenchymal stem cells,” Curr. Opin. Biotechnol. 15(5), 406–410 (2004).
[CrossRef]

T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, “Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models,” Mol. Imaging 3(1), 9–23 (2004).
[CrossRef]

I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
[CrossRef]

P. H. Wooley, “The usefulness and the limitations of animal models in identifying targets for therapy in arthritis,” Best Pract. Res. Clin. Rheumatol. 18(1), 47–58 (2004).
[CrossRef]

2003 (7)

Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
[CrossRef]

J. Leor and I. M. Barbash, “Cell transplantation and genetic engineering: new approaches to cardiac pathology,” Expert Opin. Biol. Ther. 3(7), 1023–1039 (2003).
[CrossRef]

K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
[CrossRef]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13(1), 195–208 (2003).

J. V. Frangioni, “In vivo near-infrared fluorescence imaging,” Curr. Opin. Chem. Biol. 7(5), 626–634 (2003).
[CrossRef]

J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
[CrossRef]

R. Weissleder and V. Ntziachristos, “Shedding light onto live molecular targets,” Nat. Med. 9(1), 123–128 (2003).
[CrossRef]

2002 (2)

Y. Lin, R. Weissleder, and C. H. Tung, “Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation,” Bioconjug. Chem. 13(3), 605–610 (2002).
[CrossRef]

J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
[CrossRef]

2001 (7)

J. C. Wu, G. Sundaresan, M. Iyer, and S. S. Gambhir, “Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice,” Mol. Ther. 4(4), 297–306 (2001).
[CrossRef]

B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” J. Biomed. Opt. 6(4), 432–440 (2001).
[CrossRef]

S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
[CrossRef]

J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
[CrossRef]

R. Weissleder, “A clearer vision for in vivo imaging,” Nat. Biotechnol. 19(4), 316–317 (2001).
[CrossRef]

A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
[CrossRef]

2000 (1)

G. M. Smythe, S. I. Hodgetts, and M. D. Grounds, “Immunobiology and the future of myoblast transfer therapy,” Mol. Ther. 1(4), 304–313 (2000).
[CrossRef]

1999 (3)

N. M. Wulffraat and W. Kuis, “Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?” Rheumatology (Oxford) 38(8), 764–766 (1999).
[CrossRef]

D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
[CrossRef]

C. R. Chu, F. R. Convery, W. H. Akeson, M. Meyers, and D. Amiel, “Articular cartilage transplantation. Clinical results in the knee,” Clin. Orthop. Relat. Res. 360, 159–168 (1999).
[CrossRef]

1996 (1)

M. M. Haglund, M. S. Berger, and D. W. Hochman, “Enhanced optical imaging of human gliomas and tumor margins,” Neurosurgery 38(2), 308–317 (1996).
[CrossRef]

1994 (1)

M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
[CrossRef]

1985 (1)

J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
[CrossRef]

Abinun, M.

I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
[CrossRef]

Adams, S. R.

B. N. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, “The fluorescent toolbox for assessing protein location and function,” Science 312(5771), 217–224 (2006).
[CrossRef]

Aigner, T.

K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
[CrossRef]

Akeson, W. H.

C. R. Chu, F. R. Convery, W. H. Akeson, M. Meyers, and D. Amiel, “Articular cartilage transplantation. Clinical results in the knee,” Clin. Orthop. Relat. Res. 360, 159–168 (1999).
[CrossRef]

Allen, J. B.

J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
[CrossRef]

Amiel, D.

C. R. Chu, F. R. Convery, W. H. Akeson, M. Meyers, and D. Amiel, “Articular cartilage transplantation. Clinical results in the knee,” Clin. Orthop. Relat. Res. 360, 159–168 (1999).
[CrossRef]

Arseniev, L.

M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
[CrossRef]

Bachmann, M. H.

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
[CrossRef]

Barbash, I. M.

J. Leor and I. M. Barbash, “Cell transplantation and genetic engineering: new approaches to cardiac pathology,” Expert Opin. Biol. Ther. 3(7), 1023–1039 (2003).
[CrossRef]

Barr, W. G.

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
[CrossRef]

Beilhack, A.

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

Beohar, N.

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
[CrossRef]

Berger, M. S.

M. M. Haglund, M. S. Berger, and D. W. Hochman, “Enhanced optical imaging of human gliomas and tumor margins,” Neurosurgery 38(2), 308–317 (1996).
[CrossRef]

Biswal, S.

S. Biswal, D. L. Resnick, J. M. Hoffman, and S. S. Gambhir, “Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice,” Radiology 244(3), 651–671 (2007).
[CrossRef]

Bourguignon, M.

A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
[CrossRef]

Bräuer, R.

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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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S. Biswal, D. L. Resnick, J. M. Hoffman, and S. S. Gambhir, “Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice,” Radiology 244(3), 651–671 (2007).
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J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
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S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

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B. N. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, “The fluorescent toolbox for assessing protein location and function,” Science 312(5771), 217–224 (2006).
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M. M. Haglund, M. S. Berger, and D. W. Hochman, “Enhanced optical imaging of human gliomas and tumor margins,” Neurosurgery 38(2), 308–317 (1996).
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A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
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A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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V. Gangji, M. Toungouz, and J. P. Hauzeur, “Stem cell therapy for osteonecrosis of the femoral head,” Expert Opin. Biol. Ther. 5(4), 437–442 (2005).
[CrossRef]

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E. J. Sutton, T. D. Henning, B. J. Pichler, C. Bremer, and H. E. Daldrup-Link, “Cell tracking with optical imaging,” Eur. Radiol. 18(10), 2021–2032 (2008).
[CrossRef]

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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

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A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
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M. M. Haglund, M. S. Berger, and D. W. Hochman, “Enhanced optical imaging of human gliomas and tumor margins,” Neurosurgery 38(2), 308–317 (1996).
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G. M. Smythe, S. I. Hodgetts, and M. D. Grounds, “Immunobiology and the future of myoblast transfer therapy,” Mol. Ther. 1(4), 304–313 (2000).
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S. Biswal, D. L. Resnick, J. M. Hoffman, and S. S. Gambhir, “Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice,” Radiology 244(3), 651–671 (2007).
[CrossRef]

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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
[CrossRef]

Iyer, M.

J. C. Wu, G. Sundaresan, M. Iyer, and S. S. Gambhir, “Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice,” Mol. Ther. 4(4), 297–306 (2001).
[CrossRef]

Jalenak, M.

D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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C. Jorgensen, J. Gordeladze, and D. Noel, “Tissue engineering through autologous mesenchymal stem cells,” Curr. Opin. Biotechnol. 15(5), 406–410 (2004).
[CrossRef]

Kaiser, W. A.

A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
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J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
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S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

Kim, S. H.

S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

Kloner, R. A.

J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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N. M. Wulffraat and W. Kuis, “Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?” Rheumatology (Oxford) 38(8), 764–766 (1999).
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J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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J. Leor and I. M. Barbash, “Cell transplantation and genetic engineering: new approaches to cardiac pathology,” Expert Opin. Biol. Ther. 3(7), 1023–1039 (2003).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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Y. Lin, R. Weissleder, and C. H. Tung, “Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation,” Bioconjug. Chem. 13(3), 605–610 (2002).
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M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
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Loh, Y.

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
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J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
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A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
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V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
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J. J. Mao, “Stem-cell-driven regeneration of synovial joints,” Biol. Cell 97(5), 289–301 (2005).
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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
[CrossRef]

Messerli, S. M.

Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
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G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
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A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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Min, J. J.

O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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Moutsatsos, I.

D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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Müller-Ehmsen, J.

J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” J. Biomed. Opt. 6(4), 432–440 (2001).
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M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
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M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
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Oligino, T.

S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

Oppermann, J.

I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
[CrossRef]

Osman, H.

T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
[CrossRef]

Oudina, K.

A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
[CrossRef]

Palasis, M.

T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
[CrossRef]

Park, J.

K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
[CrossRef]

Pearce, W.

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
[CrossRef]

Peterson, L.

M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” N. Engl. J. Med. 331(14), 889–895 (1994).
[CrossRef]

Petite, H.

A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
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E. J. Sutton, T. D. Henning, B. J. Pichler, C. Bremer, and H. E. Daldrup-Link, “Cell tracking with optical imaging,” Eur. Radiol. 18(10), 2021–2032 (2008).
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G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
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G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
[CrossRef]

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T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
[CrossRef]

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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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Qiao, J. H.

J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
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Quartier, P.

I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
[CrossRef]

Rapp, J. A.

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
[CrossRef]

Reeves, R.

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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S. Biswal, D. L. Resnick, J. M. Hoffman, and S. S. Gambhir, “Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice,” Radiology 244(3), 651–671 (2007).
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Rice, B.

T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, “Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models,” Mol. Imaging 3(1), 9–23 (2004).
[CrossRef]

Rice, B. W.

B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” J. Biomed. Opt. 6(4), 432–440 (2001).
[CrossRef]

Robbins, P. D.

S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

Robbins, R. C.

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

Rodriguez-Porcel, M.

O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
[CrossRef]

Saborowski, O.

G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
[CrossRef]

Sakoda, T.

J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
[CrossRef]

Sambucetti, L.

T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, “Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models,” Mol. Imaging 3(1), 9–23 (2004).
[CrossRef]

Sandora, M. R.

A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
[CrossRef]

Sauner, D.

A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
[CrossRef]

Schlegel, J.

G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
[CrossRef]

Schneider, H.

K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
[CrossRef]

Schulz, S.

Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
[CrossRef]

Sedel, L.

A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
[CrossRef]

Seroogy, C. M.

A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
[CrossRef]

Shah, K.

Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
[CrossRef]

Shivtiel, S.

V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
[CrossRef]

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G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
[CrossRef]

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G. M. Smythe, S. I. Hodgetts, and M. D. Grounds, “Immunobiology and the future of myoblast transfer therapy,” Mol. Ther. 1(4), 304–313 (2000).
[CrossRef]

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Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
[CrossRef]

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J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
[CrossRef]

J. C. Wu, G. Sundaresan, M. Iyer, and S. S. Gambhir, “Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice,” Mol. Ther. 4(4), 297–306 (2001).
[CrossRef]

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E. J. Sutton, T. D. Henning, B. J. Pichler, C. Bremer, and H. E. Daldrup-Link, “Cell tracking with optical imaging,” Eur. Radiol. 18(10), 2021–2032 (2008).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
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A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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V. Gangji, M. Toungouz, and J. P. Hauzeur, “Stem cell therapy for osteonecrosis of the femoral head,” Expert Opin. Biol. Ther. 5(4), 437–442 (2005).
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T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, “Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models,” Mol. Imaging 3(1), 9–23 (2004).
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Y. Lin, R. Weissleder, and C. H. Tung, “Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation,” Bioconjug. Chem. 13(3), 605–610 (2002).
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D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
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J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
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O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
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V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13(1), 195–208 (2003).

Y. Lin, R. Weissleder, and C. H. Tung, “Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation,” Bioconjug. Chem. 13(3), 605–610 (2002).
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R. Weissleder, “A clearer vision for in vivo imaging,” Nat. Biotechnol. 19(4), 316–317 (2001).
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R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
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J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
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T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
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P. H. Wooley, “The usefulness and the limitations of animal models in identifying targets for therapy in arthritis,” Best Pract. Res. Clin. Rheumatol. 18(1), 47–58 (2004).
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O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
[CrossRef]

J. C. Wu, G. Sundaresan, M. Iyer, and S. S. Gambhir, “Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice,” Mol. Ther. 4(4), 297–306 (2001).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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N. M. Wulffraat and W. Kuis, “Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?” Rheumatology (Oxford) 38(8), 764–766 (1999).
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Y. A. Cao, M. H. Bachmann, A. Beilhack, Y. Yang, M. Tanaka, R. J. Swijnenburg, R. Reeves, C. Taylor-Edwards, S. Schulz, T. C. Doyle, C. G. Fathman, R. C. Robbins, L. A. Herzenberg, R. S. Negrin, and C. H. Contag, “Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation,” Transplantation 80(1), 134–139 (2005).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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Ann. Rheum. Dis. (1)

I. M. de Kleer, D. M. Brinkman, A. Ferster, M. Abinun, P. Quartier, J. Van Der Net, R. Ten Cate, L. R. Wedderburn, G. Horneff, J. Oppermann, F. Zintl, H. E. Foster, A. M. Prieur, A. Fasth, M. A. Van Rossum, W. Kuis, and N. M. Wulffraat, “Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity,” Ann. Rheum. Dis. 63(10), 1318–1326 (2004).
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K. Gelse, K. von der Mark, T. Aigner, J. Park, and H. Schneider, “Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells,” Arthritis Rheum. 48(2), 430–441 (2003).
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A. Hansch, O. Frey, D. Sauner, I. Hilger, M. Haas, A. Malich, R. Bräuer, and W. A. Kaiser, “In vivo imaging of experimental arthritis with near-infrared fluorescence,” Arthritis Rheum. 50(3), 961–967 (2004).
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P. H. Wooley, “The usefulness and the limitations of animal models in identifying targets for therapy in arthritis,” Best Pract. Res. Clin. Rheumatol. 18(1), 47–58 (2004).
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Bioconjug. Chem. (1)

Y. Lin, R. Weissleder, and C. H. Tung, “Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation,” Bioconjug. Chem. 13(3), 605–610 (2002).
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Biol. Cell (1)

J. J. Mao, “Stem-cell-driven regeneration of synovial joints,” Biol. Cell 97(5), 289–301 (2005).
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M. Hofmann, K. C. Wollert, G. P. Meyer, A. Menke, L. Arseniev, B. Hertenstein, A. Ganser, W. H. Knapp, and H. Drexler, “Monitoring of bone marrow cell homing into the infarcted human myocardium,” Circulation 111(17), 2198–2202 (2005).
[CrossRef]

J. C. Wu, I. Y. Chen, G. Sundaresan, J. J. Min, A. De, J. H. Qiao, M. C. Fishbein, and S. S. Gambhir, “Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography,” Circulation 108(11), 1302–1305 (2003).
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J. V. Frangioni, “In vivo near-infrared fluorescence imaging,” Curr. Opin. Chem. Biol. 7(5), 626–634 (2003).
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Eur. Heart J. (1)

T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky, “A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction,” Eur. Heart J. 27(9), 1114–1122 (2005).
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Eur. J. Nucl. Med. Mol. Imaging (1)

G. H. Simon, H. E. Daldrup-Link, J. Kau, S. Metz, J. Schlegel, G. Piontek, O. Saborowski, S. Demos, J. Duyster, and B. J. Pichler, “Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe,” Eur. J. Nucl. Med. Mol. Imaging 33(9), 998–1006 (2006).
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Eur. Radiol. (2)

E. J. Sutton, T. D. Henning, B. J. Pichler, C. Bremer, and H. E. Daldrup-Link, “Cell tracking with optical imaging,” Eur. Radiol. 18(10), 2021–2032 (2008).
[CrossRef]

V. Ntziachristos, C. Bremer, and R. Weissleder, “Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging,” Eur. Radiol. 13(1), 195–208 (2003).

Expert Opin. Biol. Ther. (2)

J. Leor and I. M. Barbash, “Cell transplantation and genetic engineering: new approaches to cardiac pathology,” Expert Opin. Biol. Ther. 3(7), 1023–1039 (2003).
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V. Gangji, M. Toungouz, and J. P. Hauzeur, “Stem cell therapy for osteonecrosis of the femoral head,” Expert Opin. Biol. Ther. 5(4), 437–442 (2005).
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Hum. Gene Ther. (1)

Y. Tang, K. Shah, S. M. Messerli, E. Snyder, X. Breakefield, and R. Weissleder, “In vivo tracking of neural progenitor cell migration to glioblastomas,” Hum. Gene Ther. 14(13), 1247–1254 (2003).
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A. Ferrari, D. Hannouche, K. Oudina, M. Bourguignon, A. Meunier, L. Sedel, and H. Petite, “In vivo tracking of bone marrow fibroblasts with fluorescent carbocyanine dye,” J. Biomed. Mater. Res. 56(3), 361–367 (2001).
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J. Biomed. Opt. (2)

V. Kalchenko, S. Shivtiel, V. Malina, K. Lapid, S. Haramati, T. Lapidot, A. Brill, and A. Harmelin, “Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing,” J. Biomed. Opt. 11(5), 050507 (2006).
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B. W. Rice, M. D. Cable, and M. B. Nelson, “In vivo imaging of light-emitting probes,” J. Biomed. Opt. 6(4), 432–440 (2001).
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J. Clin. Invest. (2)

J. B. Allen, D. G. Malone, S. M. Wahl, G. B. Calandra, and R. L. Wilder, “Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats,” J. Clin. Invest. 76(3), 1042–1056 (1985).
[CrossRef]

A. Nakajima, C. M. Seroogy, M. R. Sandora, I. H. Tarner, G. L. Costa, C. Taylor-Edwards, M. H. Bachmann, C. H. Contag, and C. G. Fathman, “Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis,” J. Clin. Invest. 107(10), 1293–1301 (2001).
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J. Gene Med. (1)

D. Gazit, G. Turgeman, P. Kelley, E. Wang, M. Jalenak, Y. Zilberman, and I. Moutsatsos, “Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy,” J. Gene Med. 1(2), 121–133 (1999).
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S. H. Kim, S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins, “Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4,” J. Immunol. 166(5), 3499–3505 (2001).

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J. Müller-Ehmsen, P. Whittaker, R. A. Kloner, J. S. Dow, T. Sakoda, T. I. Long, P. W. Laird, and L. Kedes, “Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium,” J. Mol. Cell. Cardiol. 34(2), 107–116 (2002).
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JAMA (1)

R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler, “Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases,” JAMA 299(8), 925–936 (2008).
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Mol. Imaging (1)

T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, “Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models,” Mol. Imaging 3(1), 9–23 (2004).
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O. Gheysens, S. Lin, F. Cao, D. Wang, I. Y. Chen, M. Rodriguez-Porcel, J. J. Min, S. S. Gambhir, and J. C. Wu, “Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival,” Mol. Imaging Biol. 8(3), 163–170 (2006).
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G. M. Smythe, S. I. Hodgetts, and M. D. Grounds, “Immunobiology and the future of myoblast transfer therapy,” Mol. Ther. 1(4), 304–313 (2000).
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J. C. Wu, G. Sundaresan, M. Iyer, and S. S. Gambhir, “Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice,” Mol. Ther. 4(4), 297–306 (2001).
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R. Weissleder, “A clearer vision for in vivo imaging,” Nat. Biotechnol. 19(4), 316–317 (2001).
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J. W. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable, B. K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B. M. Moskowitz, I. D. Duncan, and J. A. Frank, “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nat. Biotechnol. 19(12), 1141–1147 (2001).
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Nat. Med. (1)

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[CrossRef]

Neurosurgery (1)

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Radiology (1)

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[CrossRef]

Rheumatology (Oxford) (1)

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Science (1)

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[CrossRef]

Transplantation (1)

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[CrossRef]

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