Abstract

Combined Magnetic Resonance (MR) and Near Infrared Spectroscopy (NIRS) has been proposed as a unique method to quantify hemodynamics, water content, and cellular size and packing density of breast tumors, as these tissue constituents can be quantified with increased resolution and overlaid on the structural features identified by the MR. However, the choices in how to reconstruct and visualize this information can have a dramatic impact on the feasibility of implementing this modality in the clinic. This is especially true in 3 dimensions, as there is often limited optical sampling of the breast tissue, and methods need to accurately reflect the tissue composition. In this paper, the implementation and display of fully 3D MR image-guided NIRS is outlined and demonstrated using in vivo data from three healthy women and a volunteer undergoing neoadjuvant chemotherapy. Additionally, a display feature presented here scales the transparency of the optical images to the sensitivity of the measurements, providing a logical way to incorporate partial volume sets of optical images onto the MR volume. These concepts are demonstrated with 3D data sets using Volview software online.

© 2008 Optical Society of America

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  1. B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
    [PubMed]
  2. D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
    [CrossRef]
  3. S. Orel and M. Schnall, "Mr imaging of the breast for detection, diagnosis, and staging of breast cancer," Radiology 220, 13-30 (2001).
    [PubMed]
  4. P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
    [PubMed]
  5. C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
    [CrossRef] [PubMed]
  6. R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
    [CrossRef] [PubMed]
  7. E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
    [CrossRef]
  8. V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
    [CrossRef] [PubMed]
  9. V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
    [CrossRef] [PubMed]
  10. B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
  11. B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
    [CrossRef] [PubMed]
  12. D. Townsend and S. Cherry, "Combining anatomy and function: the path to true image fusion," Eur. Radiol. 11, 1968-1974 (2001).
    [CrossRef] [PubMed]
  13. S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
    [PubMed]
  14. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
    [PubMed]
  15. A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
    [CrossRef]
  16. S. Fantini, S. A. Walker, M. A. Franceschini, M. Kaschke, P. M. Schlag, and K. T. Moesta, "Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods," Appl. Opt. 37, 1982-1989 (1998).
    [CrossRef]
  17. D. Grosenick, K. Moesta, H. Wabnitz, J. Mucke, C. Stroszczynski, R. Macdonald, P. Schlag, and H. Rinneberg, "Time-domain optical mammography: Initial clinical results on detection and characterization of breast tumors," Appl. Opt. 42, 3170-3186 (2003).
    [CrossRef] [PubMed]
  18. B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
    [CrossRef] [PubMed]
  19. S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
    [CrossRef] [PubMed]
  20. B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. B. Weaver, C. Kogel, and S. P. Poplack, "Combining near infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a laplacian-type regularization to incorporate mr structure," J. Biomed. Opt. 10, 050504-1-10 (2005).
    [CrossRef] [PubMed]
  21. X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
    [CrossRef] [PubMed]
  22. A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilaccio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Choriton, R. H. Moore, D. B. Kopans, and D. A. Boas, "Tomographic optical breast imaging guided by three-dimensional mammography," Appl. Opt. 42, 5181-5190 (2003).
    [CrossRef] [PubMed]
  23. P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
    [CrossRef] [PubMed]
  24. C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
    [CrossRef] [PubMed]
  25. H. Dehghani, B.W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
    [CrossRef] [PubMed]
  26. T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
    [CrossRef]
  27. S. R. Arridge and M. Schweiger, "Photon-measurement density functions. part 2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).
    [CrossRef] [PubMed]
  28. S. R. Arridge, S. M., and D. T. Delpy, "Iterative reconstruction of near infrared absorption images," Proc. SPIE 1767, 372-383 (1992).
    [CrossRef]
  29. A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005).
    [CrossRef] [PubMed]
  30. S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
    [CrossRef]
  31. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
    [CrossRef]
  32. P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
    [CrossRef] [PubMed]
  33. M. Schweiger, I. Nissila, D. Boas, and S. Arridge, "Image reconstruction in the presence of coupling errors," Appl. Opt. 46, 2743-2756 (2007).
    [CrossRef] [PubMed]
  34. J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
    [CrossRef]
  35. S. Fantini, M. A. Francheschini, A. Cerussi, J. S. Maier, S. A. Walker, B. Barbieri, B. Chance, and E. Gratton, "The effect of water in the quantitation of hemoglobin concentration in a tissue-like phantom by near-infrared spectroscopy," Biophys. J. 70, WP343-WP343 (1996). Part 2.
  36. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
    [CrossRef]
  37. A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
    [CrossRef] [PubMed]
  38. A. Li, G. Boverman, Y. Zhang, D. Brooks, E. Miller, M. Kilmer, Q. Zhang, E. Hillman, and D. Boas, "Optical linear inverse solution with multiple priors in diffuse optical tomography," Appl. Opt. 44, 1948-1956 (2005).
    [CrossRef] [PubMed]
  39. S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
    [PubMed]

2008 (1)

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

2007 (6)

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

M. Schweiger, I. Nissila, D. Boas, and S. Arridge, "Image reconstruction in the presence of coupling errors," Appl. Opt. 46, 2743-2756 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

2006 (2)

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

2005 (5)

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. Miller, M. Kilmer, Q. Zhang, E. Hillman, and D. Boas, "Optical linear inverse solution with multiple priors in diffuse optical tomography," Appl. Opt. 44, 1948-1956 (2005).
[CrossRef] [PubMed]

A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005).
[CrossRef] [PubMed]

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

2004 (4)

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

2003 (4)

2002 (3)

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

2001 (5)

S. Orel and M. Schnall, "Mr imaging of the breast for detection, diagnosis, and staging of breast cancer," Radiology 220, 13-30 (2001).
[PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

D. Townsend and S. Cherry, "Combining anatomy and function: the path to true image fusion," Eur. Radiol. 11, 1968-1974 (2001).
[CrossRef] [PubMed]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

2000 (1)

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

1999 (2)

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

1998 (1)

1997 (1)

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

1995 (1)

1992 (1)

S. R. Arridge, S. M., and D. T. Delpy, "Iterative reconstruction of near infrared absorption images," Proc. SPIE 1767, 372-383 (1992).
[CrossRef]

Arridge, S.

Arridge, S. R.

Austin-Seymour, M.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Berger, A. J.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Bevilacqua, F.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Bluemke, D.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Boas, D.

Boas, D. A.

Bone, B.

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

Boverman, G.

Briest, S.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Brooks, D.

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

Brooksby, B. A.

Brukilaccio, T. J.

Butler, J.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Carpenter, C.

Catana, C.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Causer, P.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Cerrusi, A.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

Cerussi, A.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Cerussi, A. E.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Chance, B.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

Chaves, T.

Chen, M.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Cherry, S.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

D. Townsend and S. Cherry, "Combining anatomy and function: the path to true image fusion," Eur. Radiol. 11, 1968-1974 (2001).
[CrossRef] [PubMed]

Chiou, G.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Choe, R.

Choriton, M.

Chu, Y.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Claussen, C.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Conant, E.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Corlu, A.

Cortese, A.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Czerniecki, B.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

DeAngelis, G.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

DeBruhl, N.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Dehghani, H.

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

H. Dehghani, B.W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
[CrossRef] [PubMed]

Deng, C.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Doyley, M.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

Durduran, T.

Durkin, A.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Ellis, G.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Fantini, S.

Fink, M.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Forero, J.

Franceschini, M. A.

Gatsonis, C.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Gerety, E.

Gibson, J.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

Gralow, J.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Grosenick, D.

Gulsen, S.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Guven, M.

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Harms, S.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Hartov, A.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

Hathaway, P.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Hayes, C.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Heywang-Kobrunner, S.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Hillman, E.

Hillman, E. M.

Holcombe, R. F.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Hsiang, D.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Hwang, E.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Hylton, N.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Intes, X.

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Jacobs, R.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Jakubowski, D.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Jiang, S.

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

H. Dehghani, B.W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
[CrossRef] [PubMed]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

Judenhofer, M.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Kaschke, M.

Kaufman, P.

Kennedy, F.

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

Kilmer, M.

Kilmer, M. E.

Kogel, C.

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

Kopans, D. B.

Kuhl, C.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Lanning, R.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Lee, K.

Lehman, C.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Li, A.

Macdonald, R.

Maloux, C.

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Mankoff, D.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Maravilla, K.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

McBride, T. O.

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

Meaney, P.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

Merritt, S.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Miller, E.

Miller, E. L.

Mode, R.

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

Moesta, K.

Moesta, K. T.

Moore, R. H.

Mucke, J.

Nalcioglu, O.

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Nioka, S.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Nissila, I.

Ntziachristos, V.

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

Orel, S.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

S. Orel and M. Schnall, "Mr imaging of the breast for detection, diagnosis, and staging of breast cancer," Radiology 220, 13-30 (2001).
[PubMed]

Osterberg, U. L.

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

Paulsen, K.

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

Paulsen, K. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

H. Dehghani, B.W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
[CrossRef] [PubMed]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

Pentek, Z.

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

Perbeck, L.

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

Pichler, B.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Pisano, E.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Pogue, B.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

Pogue, B. W.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

Pogue, B.W.

Poplack, S.

C. Carpenter, B. Pogue, S. Jiang, H. Dehghani, X. Wang, K. Paulsen, W. Wells, J. Forero, C. Kogel, J. Weaver, S. Poplack, and P. Kaufman, "Image-guided spectroscopy provides molecular specific information in vivo: Mriguided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

Poplack, S. P.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Procissi, D.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Qi, J.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Rinneberg, H.

Schlag, P.

Schlag, P. M.

Schnall, M.

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

S. Orel and M. Schnall, "Mr imaging of the breast for detection, diagnosis, and staging of breast cancer," Radiology 220, 13-30 (2001).
[PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

Schnall, M. D.

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

Schnitt, S.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Schweiger, M.

Shah, N.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Siegmann, K.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Sinkus, R.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Smazal, S.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Soho, S.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

Srinivasan, S.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

Stelling, C.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Stott, J.

Stroszczynski, C.

Sullivan, J.

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

Tanter, M.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Tosteson, T.

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Townsend, D.

D. Townsend and S. Cherry, "Combining anatomy and function: the path to true image fusion," Eur. Radiol. 11, 1968-1974 (2001).
[CrossRef] [PubMed]

Tromberg, B.

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

Tromberg, B. J.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Van Houten, E.

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

Veress, B.

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

Wabnitz, H.

Walker, S. A.

Wang, X.

Weatherall, P.

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

Weaver, J.

Weaver, J. B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

Wells, W.

Wells, W. A.

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Wu, T.

Wu, Y.

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

Wu, Z.

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

Xydeas, T.

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Yalavarthy, P.

P. Yalavarthy, B. Pogue, H. Dehghani, C. Carpenter, S. Jiang, and K. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007).
[CrossRef] [PubMed]

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

Yazici, T.

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Yodh, A. G.

A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

Yu, H.

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

Zhang, J.

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Zhang, Q.

Zhang, Y.

Acad. Radiol. (1)

B. Chance, S. Nioka, J. Zhang, E. Conant, E. Hwang, S. Briest, S. Orel, M. Schnall, and B. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: A six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
[CrossRef] [PubMed]

Acta. Radiol. (1)

B. Bone, Z. Pentek, L. Perbeck, and B. Veress, "Diagnostic accuracy of mammography and contrast-enhanced mr imaging in 238 histologically verified breast lesions," Acta. Radiol. 38, 489-496 (1997).
[PubMed]

Appl. Opt. (10)

S. R. Arridge and M. Schweiger, "Photon-measurement density functions. part 2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).
[CrossRef] [PubMed]

S. Fantini, S. A. Walker, M. A. Franceschini, M. Kaschke, P. M. Schlag, and K. T. Moesta, "Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods," Appl. Opt. 37, 1982-1989 (1998).
[CrossRef]

T. O. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for quantitatively assessing hemoglobin concentration and oxygenation in tissue," Appl. Opt. 38, 5480-90 (1999).
[CrossRef]

H. Dehghani, B.W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
[CrossRef] [PubMed]

D. Grosenick, K. Moesta, H. Wabnitz, J. Mucke, C. Stroszczynski, R. Macdonald, P. Schlag, and H. Rinneberg, "Time-domain optical mammography: Initial clinical results on detection and characterization of breast tumors," Appl. Opt. 42, 3170-3186 (2003).
[CrossRef] [PubMed]

A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilaccio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Choriton, R. H. Moore, D. B. Kopans, and D. A. Boas, "Tomographic optical breast imaging guided by three-dimensional mammography," Appl. Opt. 42, 5181-5190 (2003).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, and K. D. Paulsen, "Spectrally constrained chromophore and scattering nir tomography improves quantification and robustness of reconstruction," Appl. Opt. 44, 1858-1869 (2004).
[CrossRef]

A. Li, G. Boverman, Y. Zhang, D. Brooks, E. Miller, M. Kilmer, Q. Zhang, E. Hillman, and D. Boas, "Optical linear inverse solution with multiple priors in diffuse optical tomography," Appl. Opt. 44, 1948-1956 (2005).
[CrossRef] [PubMed]

A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005).
[CrossRef] [PubMed]

M. Schweiger, I. Nissila, D. Boas, and S. Arridge, "Image reconstruction in the presence of coupling errors," Appl. Opt. 46, 2743-2756 (2007).
[CrossRef] [PubMed]

Eur. Radiol. (1)

D. Townsend and S. Cherry, "Combining anatomy and function: the path to true image fusion," Eur. Radiol. 11, 1968-1974 (2001).
[CrossRef] [PubMed]

J. Am. Med. Assoc. (1)

D. Bluemke, C. Gatsonis, M. Chen, G. DeAngelis, N. DeBruhl, S. Harms, S. Heywang-Kobrunner, N. Hylton, C. Kuhl, C. Lehman, E. Pisano, P. Causer, S. Schnitt, S. Smazal, C. Stelling, P. Weatherall, and M. Schnall, "Magnetic resonance imaging of the breast prior to biopsy," J. Am. Med. Assoc. 292, 2735-2742 (2004).
[CrossRef]

J. Biomed. Opt. (3)

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Multi-spectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast," J. Biomed. Opt. 7, 72-79 (2001).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. Cerrusi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

J. Magn. Reson. Im. (1)

E. Van Houten, M. Doyley, F. Kennedy, J. Weaver, and K. Paulsen, "Initial in vivo experience with steady-state subzone-based mr elastography of the human breast," J. Magn. Reson. Im. 17, 72-85(2002).
[CrossRef]

Magn. Reson. Med. (1)

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, C. Claussen, and M. Fink, "MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography," Magn. Reson. Med. 58, 1135-1144 (2007).
[CrossRef] [PubMed]

Med. Phys. (1)

P. Yalavarthy, B. Pogue, H. Dehghani, and K. Paulsen, "Weight-matrix structured regularization provides optical generalized least-squares estimate in diffuse optical tomography," Med. Phys. 34, 2085 (2007).
[CrossRef] [PubMed]

Neoplasia (1)

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "Mri-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-54 (2002).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Phys. Med. Biol. (1)

X. Intes, C. Maloux, M. Guven, T. Yazici, and B. Chance, "Diffuse optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. USA (3)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. Tosteson, J. B. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid mri-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef] [PubMed]

C. Catana, D. Procissi, Y. Wu, M. Judenhofer, J. Qi, B. Pichler, R. Jacobs, and S. Cherry, "Simultaneous in vivo positron emission tomography and magnetic resonance imaging," Proc. Natl. Acad. Sci. USA 105, 3705-3710 (2008).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-72 (2000).
[CrossRef] [PubMed]

Proc. SPIE (2)

S. R. Arridge, S. M., and D. T. Delpy, "Iterative reconstruction of near infrared absorption images," Proc. SPIE 1767, 372-383 (1992).
[CrossRef]

J. Zhang, J. Sullivan, H. Yu, and Z. Wu, "Image-guided multimodality registration and visualization for breast cancer detection," Proc. SPIE 5744, 123-133 (2005).
[CrossRef]

Radiology (4)

S. Orel and M. Schnall, "Mr imaging of the breast for detection, diagnosis, and staging of breast cancer," Radiology 220, 13-30 (2001).
[PubMed]

P. Hathaway, D. Mankoff, K. Maravilla, M. Austin-Seymour, G. Ellis, J. Gralow, A. Cortese, C. Hayes, and R. Mode, "Value of combined fdg pet and mr imaging in the evaluation of suspected recurrent local-regional creast cancer: Preliminary experience," Radiology 210, 807-814 (1999).
[PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, O. K. S., U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

S. Poplack, T. Tosteson,W. Wells, B. Pogue, P. Meaney, A. Hartov, C. Kogel, S. Soho, J. Gibson, and K. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (2)

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, C. Kogel, M. Doyley, J. B. Weaver, and S. P. Poplack, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
[CrossRef]

Technol. Cancer Res. Treat. (2)

S. Merritt, S. Gulsen, G. Chiou, Y. Chu, C. Deng, A. Cerussi, A. Durkin, B. Tromberg, and O. Nalcioglu, "Comparison of water and lipid content measurements using diffuse optical spectroscopy and mri in emulsion phantoms," Technol. Cancer Res. Treat. 2, 563-569 (2003).
[PubMed]

S. Srinivasan, B. W. Pogue, B. Brooksby, S. Jiang, H. Dehghani, C. Kogel, W. A. Wells, S. Poplack, and K. D. Paulsen, "Near-infrared characterization of breast tumors in-vivo using spectrally-constrained reconstruction," Technol. Cancer Res. Treat. 4, 513-526 (2005).
[PubMed]

Other (2)

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. B. Weaver, C. Kogel, and S. P. Poplack, "Combining near infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a laplacian-type regularization to incorporate mr structure," J. Biomed. Opt. 10, 050504-1-10 (2005).
[CrossRef] [PubMed]

S. Fantini, M. A. Francheschini, A. Cerussi, J. S. Maier, S. A. Walker, B. Barbieri, B. Chance, and E. Gratton, "The effect of water in the quantitation of hemoglobin concentration in a tissue-like phantom by near-infrared spectroscopy," Biophys. J. 70, WP343-WP343 (1996). Part 2.

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Figures (7)

Fig. 1.
Fig. 1.

Comparison of the number of chromophores to be computed for 2D DOT, 3D DOT, and MR guided DOT.

Fig. 2.
Fig. 2.

Transforming MRI images for computational use requires 1) Segmentation of tissue types into adipose, fibroglandular, and suspicious lesions, 2) Creating a finite element mesh of the volume from surface rendering, and 3) Tagging the mesh with tissue regions.

Fig. 3.
Fig. 3.

3D gelatin phantom results. (a) MR image of the gelatin phantom. (b) Total hemoglobin (in mM), Oxygen Saturation (in %), Water (in %), Scatter-Amplitude, and Scatter Power.

Fig. 4.
Fig. 4.

Mean and standard devation chromophore values for 3D recovered optical contrasts for 3 healthy subjects.

Fig. 5.
Fig. 5.

3D Reconstructed results of multi-focal IDC of the left breast. (a) Images of a malignant tumor with three satellite lesions (2 in plane):T1-W Spin Echo MRI image and DCE-MR subtraction image. (b) Images of a malignant tumor with three satellite lesions (2 in plane) Total hemoglobin, Oxygen Saturation, Water, Scatter Amplitude, and Scatter Power.

Fig. 6.
Fig. 6.

Optical and MR overlays of subject from Figure 5. (a) Composite image (View 1) of Optical absorbing images. (b) Total Hemoglobin (View 2), Oxygen Saturation (View 3), Water (View 4), Scatter Amplitude (View 5), and Scatter Power (View 6) images.

Fig. 7.
Fig. 7.

Effect of scaling the transparency of the recovered properties to the Jacobian. Interactive volume (View 7).

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Equations (3)

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