Abstract

In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (µs), effective anisotropy factor (geff), birefringence coefficient (Δn), and fast-axis angle (Β) of normal and different kinds of atherosclerotic lesions in human vessels can be quantitatively described. Based on our findings, a quantitative PS-OCT image criterion for plaque characterization was constructed.

© 2008 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
    [CrossRef] [PubMed]
  2. M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
    [PubMed]
  3. J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
    [CrossRef] [PubMed]
  4. M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).
  5. H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
    [CrossRef] [PubMed]
  6. I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
    [CrossRef] [PubMed]
  7. D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
    [CrossRef] [PubMed]
  8. G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
    [CrossRef] [PubMed]
  9. G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
    [CrossRef] [PubMed]
  10. W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, H. C. Huang, C. Chou, G. J. Jan, "Imaging of Human Aortic Atherosclerotic plaques by Polarization-Sensitive Optical Coherence Tomography," in Proceedings of IEEE Conference on Engineering in Medicine and Biology (San Francisco, 2004), pp. 1111-1114.
  11. W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
    [CrossRef]
  12. S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
    [CrossRef] [PubMed]
  13. S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
    [CrossRef] [PubMed]
  14. W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
    [CrossRef] [PubMed]
  15. W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).
  16. W. C. Kuo, M. W. Hsiung, J. J. Shyu, N. K. Chou, and P. N. Yang, "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography," Proc. SPIE 6842, 684223-1-6842323-9 (2008).
    [CrossRef]
  17. L. Thrane, H. T. Yura, and P. E. Andersen, "Analysis of optical coherence tomography systems based on the extended Huygens-Fresenel principle," J. Opt. Soc. Am. A 17, 484-490 (2000).
    [CrossRef]
  18. D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, J. Valanciunaite, J. Swartling, S. Andersson-Engels and P. R. Hansen, "Determination of optical properties of highly-scattering media in optical coherence tomography," Opt. Express 12, 249-259 (2004).
    [CrossRef] [PubMed]
  19. C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978).
    [CrossRef] [PubMed]

2007 (3)

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

2006 (3)

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
[CrossRef] [PubMed]

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
[CrossRef] [PubMed]

2005 (1)

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

2004 (1)

2003 (1)

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

2002 (2)

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

2000 (1)

1997 (1)

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

1996 (1)

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

1995 (1)

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

1978 (1)

C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978).
[CrossRef] [PubMed]

Andersen, C. B.

Andersen, P. E.

Andersson-Engels, S.

Aretz, H. T.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Boppart, S. A.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Bouma, B. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
[CrossRef] [PubMed]

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Bresinski, M. E.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Bressner, J. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Brezinski, M.

D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
[CrossRef] [PubMed]

Brezinski, M. E.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Choi, K. B.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Chou, C.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Chou, N. K.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Courtney, B. K.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

de Boer, J. F.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Frosz, M. H.

Fujimoto, J. G.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Giattina, S. D.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Halpern, E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Halpern, E. F.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Hansen, P. R.

Harman, M.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Hee, M. R

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hee, M. R.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Herz, P. R.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Houser, S. L.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Hsiung, M. W.

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Huang, H. J.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Izatt, J. A.

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

Jan, G. J.

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Janf, I. K.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

Jang, I. K.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Jang, I-K

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
[CrossRef] [PubMed]

Kang, D. H.

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Kauffman, C. R.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Kuo, W. C.

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Lai, C. M.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Levitz, D.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Liu, B.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Metz, C. E.

C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978).
[CrossRef] [PubMed]

Nadkarni, S. K.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Park, B. H.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Park, S. J.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Park, S. W.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Pierce, M. C.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Pomerantsev, E.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Pufialito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Schlendorf, K.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Schlendorf, K. H.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Seung, K. B.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Shishkov, M.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Shortkroff, S.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Shyu, J. J.

W. C. Kuo, N. K. Chou, C. Chou, C. M. Lai, H. J. Huang, and J. J. Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt.  46, 2520-2527 (2007).
[CrossRef] [PubMed]

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Southern, J. F.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Stamper, D.

D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
[CrossRef] [PubMed]

Stamper, D. L.

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Swartling, J.

Teaeney, G. J.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Tearney, G. J.

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
[CrossRef] [PubMed]

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Thrane, L.

Tien, E. K.

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Valanciunaite, J.

Weissman, N. J.

D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
[CrossRef] [PubMed]

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

Weyman, A. E.

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

Whittaker, P.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Yabushita, H.

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Yang, P. N.

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

Yura, H. T.

Appl. Opt. (1)

Circulation (3)

M. E. Brezinski, G. J. Tearney, B. E. Bouma, J. A. Izatt, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Optical coherence tomography for optical biopsy: properties and demonstration of vascular pathology," Circulation 93, 1206-1213 (1996).
[PubMed]

H. Yabushita, B. E. Bouma, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, D. H. Kang, E. F. Halpern, and G. J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Janf, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation 107, 113-119 (2003).
[CrossRef] [PubMed]

Heart (1)

M. E. Bresinski, G. J. Tearney, N. J. Weissman, S. A. Boppart, B. E. Bouma, M. R. Hee, A. E. Weyman, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound," Heart 77, 397-403 (1997).

Int. J. Cardiol. (1)

S. D. Giattina, B. K. Courtney, P. R. Herz, M. Harman, S. Shortkroff, D. L. Stamper, B. Liu, J. G. Fujimoto, M. E. Brezinski, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," Int. J. Cardiol. 107, 400-409 (2006).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol. (3)

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Teaeney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

D. Stamper, N. J. Weissman, M. Brezinski, "Plaque characterization with optical coherence tomography," J. Am. Coll. Cardiol. 47, C69-C79 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

G. J. Tearney, I-K Jang, B. E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11, 021002 (2006).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Med. Biol. Eng. (1)

W. C. Kuo, M. W. Hsiung, and P. N. Yang, "Extracting quantitative optical properties of human vessel from PS-OCT images," Med. Biol. Eng. 27, 191-197 (2007).

Nat. Med. (1)

J. G. Fujimoto, M. E. Bresinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1, 970-972 (1995).
[CrossRef] [PubMed]

Opt. Express (1)

Proc. SPIE (1)

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, E. K. Tien, H. J. Huang, C. Chou, and G. J. Jan, "Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis," Proc. SPIE 5690, 563-571 (2005).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R Hee, T. Flotte, K. Gregory, C. A. Pufialito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Semin. Nucl. Med. (1)

C. E. Metz, "Basic principles of ROC analysis," Semin. Nucl. Med. 8, 283-298 (1978).
[CrossRef] [PubMed]

Other (2)

W. C. Kuo, J. J. Shyu, N. K. Chou, C. M. Lai, H. C. Huang, C. Chou, G. J. Jan, "Imaging of Human Aortic Atherosclerotic plaques by Polarization-Sensitive Optical Coherence Tomography," in Proceedings of IEEE Conference on Engineering in Medicine and Biology (San Francisco, 2004), pp. 1111-1114.

W. C. Kuo, M. W. Hsiung, J. J. Shyu, N. K. Chou, and P. N. Yang, "Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography," Proc. SPIE 6842, 684223-1-6842323-9 (2008).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1.
Fig. 1.

Procedure of the PS-OCT extraction algorithm.

Fig. 2.
Fig. 2.

Histological and PS-OCT images of (a) normal intima, (b) lipid lesion, (c) fibrous, and (d) fibroucalcific plaques.

Fig. 3.
Fig. 3.

Distributions of µs, g eff , Δn, and β in normal vascular intima (N), lipid laden (L), fibrous (F), and fibrocalcific (C) plaques.

Tables (5)

Tables Icon

Table 1 Kruskal Wallis Test Statistics

Tables Icon

Table 2 Mean Ranks of four optical properties extracted from the four vessel types.

Tables Icon

Table 3 Multiple comparison test

Tables Icon

Table 4 Plaque characterization by quantitative PS-OCT and histology

Tables Icon

Table 5 Quantitative plaque characterization of PS-OCT determined by histology

Equations (9)

Equations on this page are rendered with MathJax. Learn more.

i 2 ( z ) = { α 2 P R P S σ b π ω H 2 } · { exp ( 2 μ s z ) + 4 exp ( μ s z ) [ 1 exp ( μ s z ) ] 1 + ω S 2 ω H 2 + [ 1 exp ( μ s z ) ] 2 ω H 2 ω S 2 }
R i R j > Z α k ( k 1 ) × n t ( n t + 1 ) 12 × ( 1 n i + 1 n j )
logit [ OR ( diseased vessel type ) OR ( Normal vessel ) ] = A r + B X
Accuracy = TP + TN TP + TN + FP + FN
Sensitivity = TP TP + FN
Specificity = TN TN + FP
logit [ OR ( type = C ) OR ( type = N ) ] = 19.182 + 0.044 X μ s + 0.119 X Δ n + 0.141 X β
logit [ OR ( type = F ) OR ( type = N ) ] = 19.377 + 0.047 X μ s + 0.068 X Δ n + 0.201 X β
logit [ OR ( type = L ) OR ( type = N ) ] = 9.746 + 0.008 X μ s + 0.028 X Δ n + 0.113 X β

Metrics