Abstract

We describe a side-firing fiber optic sensor based on near-infrared spectroscopy for guiding core needle biopsy diagnosis of breast cancer. The sensor is composed of three side firing optical fibers (two source fibers and one detection fiber), providing two source-detector separations. The entire assembly is inserted into a core biopsy needle, allowing for sampling to occur at the biopsy site. A multi-wavelength frequency-domain near-infrared instrument is used to collect diffuse reflectance in the breast tissue through an aperture on the biopsy needle before the tissue is removed for histology. Preliminary in vivo measurements performed on 10 normal or benign breast tissues from 5 women undergoing stereo- or ultrasound-guided core needle biopsy show the ability of the system to determine tissue optical properties and constituent concentrations, which are correlated with breast tissue composition derived from histopathology.

© 2007 Optical Society of America

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  59. B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
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  60. S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
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    [CrossRef] [PubMed]

2007

2006

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

2005

M. K. Simick and L. Lilge, "Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk," Br. J. Radiol. 78, 1009-1017 (2005).
[CrossRef] [PubMed]

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
[CrossRef] [PubMed]

B. J. Tromberg, A. E. Cerussi, S. N, M. Compton, A. Durkin, H. D, B. J, and R. Mehta, "Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy," Breast Cancer Res. 7, 276-278 (2005).
[CrossRef]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005).
[CrossRef] [PubMed]

2004

C. Lubawy and N. Ramanujam, "Endoscopically compatible near-infrared photon migration probe," Opt. Lett. 29, 2022-2024 (2004).
[CrossRef] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

R. L. P. v. Veen, H. J. C. M. Sterenborg, A. W. K. S. Marinelli, and M. Menke-Pluymers, "Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography," J. Biomed. Opt. 9, 1129-1136 (2004).
[CrossRef] [PubMed]

L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini, and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

M. K. Simick, R. Jong, B. Wilson, and L. Lilge, "Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk," J. Biomed. Opt. 9, 794-803 (2004).
[CrossRef] [PubMed]

H. S. Feigelson, C. R. Jonas, L. R. Teras, M. J. Thun, and E. E. Calle, "Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study," Cancer Epidemiol Biomarkers Prev. 13, 220-224 (2004).
[CrossRef] [PubMed]

2003

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

2002

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Z. Sun, Y. Huang, and E. M. Sevick-Muraca, "Precise analysis of frequency domain photon migration measurement for characterization of concentrated colloidal suspensions," Rev. Sci. Instrum. 73, 383-393 (2002).
[CrossRef]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

2001

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
[CrossRef] [PubMed]

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
[CrossRef] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

2000

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
[PubMed]

F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

P. Vaupel and M. Hockel, "Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance," Int. J. Oncol. 17, 869-879 (2000).
[PubMed]

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

1999

R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
[PubMed]

1998

B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, "Phase measurement of light absorption and scatter in human tissue," Rev. Sci. Instrum. 69, 3457-81 (1998).
[CrossRef]

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
[PubMed]

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

S. Thomsen and D. Tatman, "Physiological and Pathological factors of human breast disease that can influence optical diagnosis," Ann. NY Acad. Sci. 838, 171-193 (1998).
[CrossRef] [PubMed]

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
[CrossRef]

1997

B. W. Pogue, M. Testorf, T. McBride, U. Osterberg, and K. Paulsen, "Instrumentation and design of a frequencydomain diffuse optical tomography imager for breast cancer detection," Opt. Express 1, 391-403 (1997).
[CrossRef] [PubMed]

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
[PubMed]

L. Liberman, L. R. LaTrenta, and D. D. Dershaw, "Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins," AJR Am J Roentgenol. 169, 1464-1465 (1997).
[PubMed]

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

D. N. Smith, R. Christian, and J. E. Meyer, "Large-core needle biopsy of nonpalpable breast cancers. The impact on subsequent surgical excisions," Arch. Surg. 132, 256-259 (1997).
[CrossRef] [PubMed]

1996

L. L. Fajardo, "Cost-effectiveness of stereotaxic breast core needle biopsy," Acad. Radiol. 3, S21-S23 (1996).
[CrossRef] [PubMed]

D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
[PubMed]

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
[CrossRef]

1995

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
[PubMed]

J. B. Fishkin, P. T. C. So, A. E. Cerussi, E. Gratton, S. Fantini, and M. A. Franceschini, "Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom," Appl. Opt. 34, 1143-1155 (1995).
[CrossRef] [PubMed]

1994

R. C. Haskell, L. O. Svaasand, T.-T. Tsay, T.-C. Feng, M. S. McAdams, and B. J. Tromberg, "Boundary conditions for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A 11, 2727-2741 (1994).
[CrossRef]

B. Pogue and M. Patterson, "Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory," Phys. Med. Biol. 39, 1157-1180 (1994).
[CrossRef] [PubMed]

1992

P. Vaupel, K. Schlenger, M. Hoeckel, and P. Okunieff, "Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients," Adv. Exp. Med. Biol. 316, 361-371 (1992).
[CrossRef] [PubMed]

1991

P. Vaupel, K. Schlenger, C. Knoop, and M. Hockel, "Oxygenation of human tumors: evaluation of tissue oxygen distribution inbreast cancers by computerized O2 tension measurements," Cancer Res. 51, 3316-3322 (1991).
[PubMed]

Abramson, A. F.

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
[PubMed]

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

Anderson, E.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Andersson-Engels, S.

T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
[CrossRef] [PubMed]

Arridge, S. R.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Aydiner, A.

F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

Bak, M.

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
[PubMed]

Bassi, A.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

Bentley, R. C.

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
[CrossRef] [PubMed]

Berger, A. J.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

Bernreuter, W.

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
[PubMed]

Bevilacqua, F.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

Bevilacqua, F. E.

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

Bonaccio, E.

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

Borgen, P. I.

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Butler, J.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

Calle, E. E.

H. S. Feigelson, C. R. Jonas, L. R. Teras, M. J. Thun, and E. E. Calle, "Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study," Cancer Epidemiol Biomarkers Prev. 13, 220-224 (2004).
[CrossRef] [PubMed]

Carpenter, C. M.

Cerussi, A.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

Cerussi, A. E.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

B. J. Tromberg, A. E. Cerussi, S. N, M. Compton, A. Durkin, H. D, B. J, and R. Mehta, "Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy," Breast Cancer Res. 7, 276-278 (2005).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

J. B. Fishkin, P. T. C. So, A. E. Cerussi, E. Gratton, S. Fantini, and M. A. Franceschini, "Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom," Appl. Opt. 34, 1143-1155 (1995).
[CrossRef] [PubMed]

Chance, B.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, "Phase measurement of light absorption and scatter in human tissue," Rev. Sci. Instrum. 69, 3457-81 (1998).
[CrossRef]

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
[CrossRef]

Choe, R.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Christian, R.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
[PubMed]

D. N. Smith, R. Christian, and J. E. Meyer, "Large-core needle biopsy of nonpalpable breast cancers. The impact on subsequent surgical excisions," Arch. Surg. 132, 256-259 (1997).
[CrossRef] [PubMed]

Cohen, M. A.

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

Cope, M.

B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, "Phase measurement of light absorption and scatter in human tissue," Rev. Sci. Instrum. 69, 3457-81 (1998).
[CrossRef]

Coquoz, O.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Corlu, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Coshic, O.

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
[CrossRef] [PubMed]

Cubeddu, R.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini, and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004).
[CrossRef] [PubMed]

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

Culver, J. P.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Czerniecki, B. J.

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005).
[CrossRef] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

D’Andrea, C.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

D'Andrea, C.

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

Danesini, G. M.

L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini, and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004).
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Dehghani, H.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
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S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
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B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
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S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

DeMichele, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
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E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
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J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
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L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
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L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
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L. Liberman, L. R. LaTrenta, and D. D. Dershaw, "Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins," AJR Am J Roentgenol. 169, 1464-1465 (1997).
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D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
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L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
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DiPiro, P.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
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F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

Durduran, T.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Durkin, A.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Dwivedi, S.

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
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Egglin, T. K.

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
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Eker, C.

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
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Espinoza, J.

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
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B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
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Fahs, M. C.

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
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Fajardo, L. L.

L. L. Fajardo, "Cost-effectiveness of stereotaxic breast core needle biopsy," Acad. Radiol. 3, S21-S23 (1996).
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Fantini, H. J. S.

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
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Fantini, S.

Feigelson, H. S.

H. S. Feigelson, C. R. Jonas, L. R. Teras, M. J. Thun, and E. E. Calle, "Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study," Cancer Epidemiol Biomarkers Prev. 13, 220-224 (2004).
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Feng, T. L.

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

Feng, T.-C.

Filippidis, G.

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Finkelstein, S. I.

R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
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Fishkin, J.

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
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Fishkin, J. B.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
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J. B. Fishkin, P. T. C. So, A. E. Cerussi, E. Gratton, S. Fantini, and M. A. Franceschini, "Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom," Appl. Opt. 34, 1143-1155 (1995).
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Forero, J.

Fraker, D. L.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Franceschini, M. A.

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
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J. B. Fishkin, P. T. C. So, A. E. Cerussi, E. Gratton, S. Fantini, and M. A. Franceschini, "Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom," Appl. Opt. 34, 1143-1155 (1995).
[CrossRef] [PubMed]

Garofalakis, A.

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Giammarco, J.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Gibson, J.

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

Gibson, J. J.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

Giusto, A.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

Grabau, D. A.

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
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Gratton, E.

Grosicka-Koptyra, M.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
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Halperin, T. J.

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
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Hann, L. E.

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

Hansen, S.

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
[PubMed]

Harvey, S.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
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Haskell, R. C.

Hockel, M.

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P. Vaupel, K. Schlenger, M. Hoeckel, and P. Okunieff, "Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients," Adv. Exp. Med. Biol. 316, 361-371 (1992).
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Holboke, M. J.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Holcombe, R. F.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

Hornung, R.

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

Hsiang, D.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

Huang, Y.

Z. Sun, Y. Huang, and E. M. Sevick-Muraca, "Precise analysis of frequency domain photon migration measurement for characterization of concentrated colloidal suspensions," Rev. Sci. Instrum. 73, 383-393 (2002).
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Ingvar, C.

T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
[CrossRef] [PubMed]

Iplikci, A.

F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

Jackman, R. J.

R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
[PubMed]

Jagannathan, N.

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
[CrossRef] [PubMed]

Jakubowski, D.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

Jakubowski, D. B.

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

Jiang, S.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

Jonas, C. R.

H. S. Feigelson, C. R. Jonas, L. R. Teras, M. J. Thun, and E. E. Calle, "Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study," Cancer Epidemiol Biomarkers Prev. 13, 220-224 (2004).
[CrossRef] [PubMed]

Jong, R.

M. K. Simick, R. Jong, B. Wilson, and L. Lilge, "Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk," J. Biomed. Opt. 9, 794-803 (2004).
[CrossRef] [PubMed]

Julka, P.

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
[CrossRef] [PubMed]

Kafousi, M.

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Kaneko, M.

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
[CrossRef]

Kaschke, M.

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
[CrossRef]

Kaufman, P. A.

Knoop, C.

P. Vaupel, K. Schlenger, C. Knoop, and M. Hockel, "Oxygenation of human tumors: evaluation of tissue oxygen distribution inbreast cancers by computerized O2 tension measurements," Cancer Res. 51, 3316-3322 (1991).
[PubMed]

Ko, W.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
[PubMed]

Kogel, C.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

Konecky, S. D.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Kumar, M.

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
[CrossRef] [PubMed]

Lanning, R.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
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B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

LaTrenta, L. R.

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

L. Liberman, L. R. LaTrenta, and D. D. Dershaw, "Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins," AJR Am J Roentgenol. 169, 1464-1465 (1997).
[PubMed]

Lee, C. H.

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
[PubMed]

Lee, K.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Lester, S.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
[PubMed]

Liberman, L.

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

L. Liberman, L. R. LaTrenta, and D. D. Dershaw, "Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins," AJR Am J Roentgenol. 169, 1464-1465 (1997).
[PubMed]

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
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D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
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L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
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Lilge, L.

M. K. Simick and L. Lilge, "Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk," Br. J. Radiol. 78, 1009-1017 (2005).
[CrossRef] [PubMed]

M. K. Simick, R. Jong, B. Wilson, and L. Lilge, "Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk," J. Biomed. Opt. 9, 794-803 (2004).
[CrossRef] [PubMed]

Lindblom, P.

T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
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Lubawy, C.

Maddox, W.

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
[PubMed]

Mainiero, M. B.

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
[PubMed]

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R. L. P. v. Veen, H. J. C. M. Sterenborg, A. W. K. S. Marinelli, and M. Menke-Pluymers, "Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography," J. Biomed. Opt. 9, 1129-1136 (2004).
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R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
[PubMed]

McAdams, M. S.

McBride, T.

McBride, T. O.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Menke-Pluymers, M.

R. L. P. v. Veen, H. J. C. M. Sterenborg, A. W. K. S. Marinelli, and M. Menke-Pluymers, "Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography," J. Biomed. Opt. 9, 1129-1136 (2004).
[CrossRef] [PubMed]

Meyer, J.

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
[PubMed]

Meyer, J. E.

D. N. Smith, R. Christian, and J. E. Meyer, "Large-core needle biopsy of nonpalpable breast cancers. The impact on subsequent surgical excisions," Arch. Surg. 132, 256-259 (1997).
[CrossRef] [PubMed]

Moesta, K. T.

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
[CrossRef]

Morris, E. A.

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
[PubMed]

Nowels, K. W.

R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
[PubMed]

Ohta, K.

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
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Okunieff, P.

P. Vaupel, K. Schlenger, M. Hoeckel, and P. Okunieff, "Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients," Adv. Exp. Med. Biol. 316, 361-371 (1992).
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Olson, J. A. J.

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
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Osterberg, U.

Osterberg, U. L.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Osterman, K. S.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Papazoglou, T.

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Patterson, M.

B. Pogue and M. Patterson, "Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory," Phys. Med. Biol. 39, 1157-1180 (1994).
[CrossRef] [PubMed]

Paulsen, K.

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

B. W. Pogue, M. Testorf, T. McBride, U. Osterberg, and K. Paulsen, "Instrumentation and design of a frequencydomain diffuse optical tomography imager for breast cancer detection," Opt. Express 1, 391-403 (1997).
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Paulsen, K. D.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
[PubMed]

Pham, T.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
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Pham, T. H.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
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Philpotts, L.

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
[PubMed]

Pifferi, A.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
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L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini, and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004).
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R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

Pile, N.

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
[PubMed]

Pogue, B.

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

B. Pogue and M. Patterson, "Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory," Phys. Med. Biol. 39, 1157-1180 (1994).
[CrossRef] [PubMed]

Pogue, B. W.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

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E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
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B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
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B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
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S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
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S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
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B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
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S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
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N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
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Svaasand, L. O.

Svensson, T.

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A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
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T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
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Torricelli, A.

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

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[CrossRef] [PubMed]

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[CrossRef] [PubMed]

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
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Tosteson, T.

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

Tosteson, T. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

Totkas, S.

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
[CrossRef]

Tromberg, B.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, "Phase measurement of light absorption and scatter in human tissue," Rev. Sci. Instrum. 69, 3457-81 (1998).
[CrossRef]

Tromberg, B. J.

B. J. Tromberg, A. E. Cerussi, S. N, M. Compton, A. Durkin, H. D, B. J, and R. Mehta, "Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy," Breast Cancer Res. 7, 276-278 (2005).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

R. C. Haskell, L. O. Svaasand, T.-T. Tsay, T.-C. Feng, M. S. McAdams, and B. J. Tromberg, "Boundary conditions for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A 11, 2727-2741 (1994).
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A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Urist, M.

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
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R. L. P. v. Veen, H. J. C. M. Sterenborg, A. W. K. S. Marinelli, and M. Menke-Pluymers, "Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography," J. Biomed. Opt. 9, 1129-1136 (2004).
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Vach, W.

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
[PubMed]

Valentini, G.

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

Vaupel, P.

P. Vaupel and M. Hockel, "Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance," Int. J. Oncol. 17, 869-879 (2000).
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P. Vaupel, K. Schlenger, M. Hoeckel, and P. Okunieff, "Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients," Adv. Exp. Med. Biol. 316, 361-371 (1992).
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P. Vaupel, K. Schlenger, C. Knoop, and M. Hockel, "Oxygenation of human tumors: evaluation of tissue oxygen distribution inbreast cancers by computerized O2 tension measurements," Cancer Res. 51, 3316-3322 (1991).
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Vlastos, G.

G. Vlastos and H. M. Verkooijen, "Minimally invasive approaches for diagnosis and treatment of early-stage breast cancer," The Oncologist 12, 1-10 (2007).
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Wang, X.

Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

Weaver, J. B.

Wells, W. A.

White, R. R.

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
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Wilson, B.

M. K. Simick, R. Jong, B. Wilson, and L. Lilge, "Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk," J. Biomed. Opt. 9, 794-803 (2004).
[CrossRef] [PubMed]

Yamashita, Y.

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
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Yavuz, E.

F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

Yodh, A. G.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, "Diffuse optical measurement of blood flow in breast tumors," Opt. Lett. 30, 2915-2917 (2005).
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T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
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Yoshida, M.

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
[CrossRef]

Yu, G.

Zacharakis, G.

A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

Zhou, C.

Zubkov, L.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
[CrossRef] [PubMed]

Acad Radiol.

A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Sources of absorption and scattering contrast for near-infrared optical mammography," Acad Radiol. 8, 211-218 (2001).

Acad. Radiol.

S. Srinivasan, B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. Gibson, T. Tosteson, S. Poplack, and K. Paulsen, "In Vivo Hemoglobin and Water Concentrations, Oxygen Saturation, and Scattering Estimates From Near-Infrared Breast Tomography Using Spectral Reconstruction," Acad. Radiol. 13, 195-202 (2006).
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L. L. Fajardo, "Cost-effectiveness of stereotaxic breast core needle biopsy," Acad. Radiol. 3, S21-S23 (1996).
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Adv. Exp. Med. Biol.

P. Vaupel, K. Schlenger, M. Hoeckel, and P. Okunieff, "Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients," Adv. Exp. Med. Biol. 316, 361-371 (1992).
[CrossRef] [PubMed]

AJR Am J Roentgenol.

L. Liberman, L. R. LaTrenta, and D. D. Dershaw, "Impact of core biopsy on the surgical management of impalpable breast cancer: another look at margins," AJR Am J Roentgenol. 169, 1464-1465 (1997).
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L. Liberman, L. R. LaTrenta, D. D. Dershaw, A. F. Abramson, E. A. Morris, M. A. Cohen, P. P. Rosen, and P. I. Borgen, "Impact of core biopsy on the surgical management of impalpable breast cancer," AJR Am J Roentgenol. 168, 495-499 (1997).
[PubMed]

Am. J. Clin. Oncol.

F. Tas, E. Yavuz, A. Aydiner, P. Saip, R. Disci, A. Iplikci, and E. Topuz, "Angiogenesis and p53 protein expression in breast cancer: prognostic roles and interrelationships," Am. J. Clin. Oncol. 23, 546-553 (2000).

Ann. NY Acad. Sci.

S. Thomsen and D. Tatman, "Physiological and Pathological factors of human breast disease that can influence optical diagnosis," Ann. NY Acad. Sci. 838, 171-193 (1998).
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Ann. Surg.

R. R. White, T. J. Halperin, J. A. J. Olson, M. S. Soo, R. C. Bentley, and H. F. Seigler, "Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities," Ann. Surg. 233, 769-777 (2001).
[CrossRef] [PubMed]

Appl. Opt.

Arch. Surg.

D. N. Smith, R. Christian, and J. E. Meyer, "Large-core needle biopsy of nonpalpable breast cancers. The impact on subsequent surgical excisions," Arch. Surg. 132, 256-259 (1997).
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Br. J. Cancer

S. Hansen, D. A. Grabau, F. B. Sørensen, M. Bak, W. Vach, and C. Rose, "Vascular grading of angiogenesis: prognostic significance in breast cancer," Br. J. Cancer 82, 339-347 (2000).
[PubMed]

N. Jagannathan, M. Kumar, V. Seenu, O. Coshic, S. Dwivedi, P. Julka, A. Srivastava, and G. Rath, "Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer," Br. J. Cancer 84,1016-1022 (2001).
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Br. J. Radiol.

M. K. Simick and L. Lilge, "Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk," Br. J. Radiol. 78, 1009-1017 (2005).
[CrossRef] [PubMed]

Breast Cancer Res.

B. J. Tromberg, A. E. Cerussi, S. N, M. Compton, A. Durkin, H. D, B. J, and R. Mehta, "Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy," Breast Cancer Res. 7, 276-278 (2005).
[CrossRef]

Cancer Epidemiol Biomarkers Prev.

H. S. Feigelson, C. R. Jonas, L. R. Teras, M. J. Thun, and E. E. Calle, "Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study," Cancer Epidemiol Biomarkers Prev. 13, 220-224 (2004).
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Cancer Res.

P. Vaupel, K. Schlenger, C. Knoop, and M. Hockel, "Oxygenation of human tumors: evaluation of tissue oxygen distribution inbreast cancers by computerized O2 tension measurements," Cancer Res. 51, 3316-3322 (1991).
[PubMed]

Int. J. Oncol.

P. Vaupel and M. Hockel, "Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance," Int. J. Oncol. 17, 869-879 (2000).
[PubMed]

J. Biomed. Opt.

K. Suzuki, Y. Yamashita, K. Ohta, M. Kaneko, M. Yoshida, and B. Chance, "Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women," J. Biomed. Opt. 1, 330-334 (1996).
[CrossRef]

L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. M. Danesini, and R. Cubeddu, "Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography," J. Biomed. Opt. 9, 1137-1142 (2004).
[CrossRef] [PubMed]

R. L. P. v. Veen, H. J. C. M. Sterenborg, A. W. K. S. Marinelli, and M. Menke-Pluymers, "Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography," J. Biomed. Opt. 9, 1129-1136 (2004).
[CrossRef] [PubMed]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, "Spectroscopy enhances the information content of optical mammography," J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef] [PubMed]

M. K. Simick, R. Jong, B. Wilson, and L. Lilge, "Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk," J. Biomed. Opt. 9, 794-803 (2004).
[CrossRef] [PubMed]

B. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T. Tosteson, S. Poplack, and K. Paulsen, "Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes," J. Biomed. Opt. 9, 541-552 (2004).
[CrossRef] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. E. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef] [PubMed]

A. Bassi, L. Spinelli, C. D’Andrea, A. Giusto, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu, "Feasibility of white-light time-resolved optical mammography," J. Biomed. Opt. 11, 054035 (2006).
[CrossRef] [PubMed]

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

K. T. Moesta, H. J. S. Fantini, S. Totkas, M. A. Franceschini, M. Kaschke, and P. M. Schlag, "Contrast Features of Breast Cancer in Frequency-Domain Laser Scanning Mammography," J. Biomed. Opt. 3,129-136 (1998).
[CrossRef]

J. Opt. Soc. Am. A

Med. Phys.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI," Med. Phys. 32, 1128-1139 (2005).
[CrossRef] [PubMed]

Neoplasia

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, "Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy," Neoplasia 2, 26-40 (2000).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Photochem. Photobiol.

R. Cubeddu, C. D'Andrea, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, "Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast," Photochem. Photobiol. 72, 383-391 (2000).
[PubMed]

Phys. Med. Biol.

T. Svensson, J. Swartling, P. Taroni, A. Torricelli, P. Lindblom, C. Ingvar, and S. Andersson-Engels, "Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy," Phys. Med. Biol. 50, 2559-2571 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Phys. Med. Biol. 47, 2847-2861 (2002).
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B. Pogue and M. Patterson, "Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory," Phys. Med. Biol. 39, 1157-1180 (1994).
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A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. Tsiftsis, E. Stathopoulos, M. Kafousi, J. Ripoll, and T. Papazoglou, "Optical characterization of thin female breast biopsies based on the reduced scattering coefficient," Phys. Med. Biol. 50, 2583-2596 (2005).
[CrossRef] [PubMed]

PNAS

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography," PNAS 100, 12349-12354 (2003).
[CrossRef] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography," PNAS 103, 8828-8833 (2006).
[CrossRef] [PubMed]

N. Shah, A. E. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung, and B. Tromberg, "Noninvasive functional optical spectroscopy of human breast tissue," PNAS 98, 4420-4425 (2001).
[CrossRef] [PubMed]

Radiology

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
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R. J. Jackman, K. W. Nowels, J. Rodriguez-Soto, F. A. Marzoni, S. I. Finkelstein, and M. J. Shepard, "Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up " Radiology 210, 799-805 (1999).
[PubMed]

L. Liberman, M. C. Fahs, D. D. Dershaw, E. Bonaccio, A. F. Abramson, M. A. Cohen, and L. E. Hann, "Impact of stereotaxic core breast biopsy on cost of diagnosis," Radiology 195, 633-637 (1995).
[PubMed]

C. H. Lee, T. K. Egglin, L. Philpotts, M. B. Mainiero, and I. Tocino, "Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings," Radiology 202, 849-854 (1997).
[PubMed]

L. Liberman, T. L. Feng, D. D. Dershaw, E. A. Morris, and A. F. Abramson, "US-guided core breast biopsy: use and cost-effectiveness," Radiology 208, 717-723 (1998).
[PubMed]

E. Rubin, P. Dempsey, N. Pile, W. Bernreuter, M. Urist, C. Shumate, and W. Maddox, "Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield," Radiology 195, 627-631 (1995).
[PubMed]

J. Meyer, D. Smith, S. Lester, P. DiPiro, C. Denison, S. Harvey, R. Christian, A. Richardson, and W. Ko, "Large-needle core biopsy: nonmalignant breast abnormalities evaluated with surgical excision or repeat core biopsy," Radiology 206, 717-720 (1998).
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D. D. Dershaw, E. A. Morris, L. Liberman, and A. F. Abramson, "Nondiagnostic stereotaxic core breast biopsy: results of rebiopsy "Radiology 198, 323-325 (1996).
[PubMed]

Rev. Sci. Instrum.

B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, "Phase measurement of light absorption and scatter in human tissue," Rev. Sci. Instrum. 69, 3457-81 (1998).
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Z. Sun, Y. Huang, and E. M. Sevick-Muraca, "Precise analysis of frequency domain photon migration measurement for characterization of concentrated colloidal suspensions," Rev. Sci. Instrum. 73, 383-393 (2002).
[CrossRef]

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, "Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy," Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

The Oncologist

G. Vlastos and H. M. Verkooijen, "Minimally invasive approaches for diagnosis and treatment of early-stage breast cancer," The Oncologist 12, 1-10 (2007).
[CrossRef] [PubMed]

Other

SUROS News Release, "New method for breast cancer diagnosis" (Suros Surgical Systems, Inc., 2003). http://www.surossurgical.com/pdf/PressReleases/2003/OctoberCampaign2003.pdf.

ECRI Report, "Breast biopsy more effective in detecting cancer than noninvasive diagnostic tests" (ECRI, Oct. 16, 2006). http://www.medicalnewstoday.com/medicalnews.php?newsid=38967

D. Prate "Mammograms cause breast cancer (and other cancer facts you probably never knew)" (NewsTarget Network, 2005). http://www.newstarget.com/010886.html

H. Singhal, L. M. Lai, and W. Teh "Breast, stereotactic core biopsy/fine needle aspiration" (EMedicine, 2005). http://www.emedicine.com/radio/topic768.htm

R. Choe, Diffuse optical tomography and spectroscopy of breast cancer and fetal brain, in Physics and Astronomy. 2005, University of Pennsylvania: Philadelphia.
[PubMed]

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Figures (5)

Fig. 1.
Fig. 1.

(Color online) (a) a schematic of the side-firing probe inside a biopsy needle and (b) a photograph of the entire probe next to the Suros 9 Gauge needle (Suros Surgical Systems, Inc.).

Fig. 2.
Fig. 2.

(Color online) Frequency-domain NIR instrument, (a) Schematics; (b) Picture.

Fig. 3.
Fig. 3.

Pearson’s correlation between age and (a) adipose content; (b) fibroglandular content; and (c) blood content in normal/benign female breast tissues. Filled squares represent PRE samples, open triangles represent the HRT sample, open circle represent POST samples, and solid lines represent a linear fit across all the samples. Pearson’s coefficient was used in calculating the correlations.

Fig. 4.
Fig. 4.

μa and μs’ at 849 nm versus percent adipose, fibroglandular and blood contents. Filled squares represent PRE samples, open triangles represent the HRT sample, open circle represent POST samples, and solid lines represent a linear fit across all the samples. Pearson’s coefficient was used in calculating the correlations.

Fig. 5.
Fig. 5.

Total hemoglobin concentration (THC) and blood oxygen saturation (SO2) obtained using 3 wavelength data. Filled squares represent PRE samples, open triangles represent the HRT sample, open circles represent POST samples, and solid lines represent a linear fit across all the samples. Pearson’s coefficient was used in calculating the correlations.

Tables (1)

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Table 1: Age and Menopausal Status of the Subjects and Histological Breakdown of the Optically Interrogated Tissue Sites in These Patients.

Equations (5)

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ln ( r r 0 AC rel ) = ln ( r AC ( r ) r 0 ∙AC ( r 0 ) ) = ( r r 0 ) 3 μ a ( μ a + μ s ' ) 2 × [ 1 + ( ω v μ a ) 2 + 1 ] 1 2
Δϕ rel = ϕ ( r ) ϕ ( r 0 ) = ( r r 0 ) 3 μ a ( μ a + μ s ' ) 2 × [ 1 + ( ω v μ a ) 2 1 ] 1 2
AC rel _ theoretical ( λ i ) = X ( λ i ) AC rel _ phantom ( λ i ) + Y ( λ i )
Δϕ rel _ theoretical ( λ i ) = Δϕ rel _ theoretical ( λ i ) + Z ( λ i )
μ a ( λ i ) = 2.303 × [ ε Hb ( λ i ) C Hb + ε Hb O 2 ( λ i ) C Hb O 2 + ε lipid ( λ i ) C lipid + ε water ( λ i ) C water ]

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