Abstract

A reliable and power-scalable extended cavity diode-pumped passively mode-locked Yb:KGW laser generating ~200 fs long pulses at a repetition rate of 15 MHz was developed and characterized. The laser delivered up to 150 mW of average power at fundamental wavelength of 1040 nm, corresponding to a pulse energy of 10 nJ. The laser radiation was frequency-doubled in a single pass configuration within a nonlinear BIBO crystal to produce femtosecond green radiation at 520 nm with peak power of ~200 W. The generated second harmonic served as an excitation source for an optical DNA biosensor based on fluorescence lifetime measurements obtained using the time-correlated single photon counting technique.

© 2006 Optical Society of America

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2005

2004

T. Harimoto, Y. Takeuchi, M. Fujita, "Spectral properties of second-harmonic generation at 800 nm in a BiB3O6 crystal," Opt. Express 12, 811-816 (2004).
[CrossRef] [PubMed]

M. Ghotbi, M. Ebrahim-Zadeh, A. Majchrowski, E. Michalski, and I. V. Kityk, "High-average-power femtosecond pulse generation in the blue using BiB3O6," Opt. Lett. 29, 2530-2532 (2004).
[CrossRef] [PubMed]

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

G. Paunescu, J. Hein and R. Sauerbrey, "100-fs diode-pumped Yb:KGW mode-locked laser," Appl. Phys. B 79, 555-558 (2004).
[CrossRef]

G. I. Petrov, V. V. Yakovlev, N. I. Minkovski, "Broadband nonlinear optical conversion of a high-energy diode-pumped picosecond laser," Opt. Commun. 229, 441-445 (2004).
[CrossRef]

2003

2002

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

2001

2000

F. Brunner, G. J. Spühler, J. Aus der Au, L. Krainer, F. Morier-Genoud, R. Paschotta, N. Lichtenstein, S. Weiss, C. Harder, A. A. Lagatsky, A. Abdolvand, N. V. Kuleshov, and U. Keller, "Diode-pumped femtosecond Yb:KGd(WO4)2 laser with 1.1W average output," Opt. Lett. 25, 1119-1121 (2000).
[CrossRef]

H. Hellwig, J. Liebertz, and L. Bohaty, "Linear optical properties of the monoclinic bismuth borate BiB3O6," J. Appl. Phys. 88, 240-244 (2000).
[CrossRef]

R. Paschotta, J. Aus der Au, G. J. Spühler, F. Morier-Genoud, R.Hövel, M. Moser, S. Erhard, M. Karszewski, A. Giesen, and U. Keller, "Diode-pumped passively mode-locked lasers with high average power," Appl. Phys. B 70, S25-S31 (2000).
[CrossRef]

1999

H. Hellwig, J. Liebertz, and L. Bohaty, "Exceptional large nonlinear optical coefficients in the monoclinic bismuth borate BiB3O6," Solid State Commun. 109, 249-251 (1999).
[CrossRef]

1997

1993

1989

1977

J. Olmsted and D. R. Kearns, "Mechanism of ethidium bromide fluorescence enhancement on binding to nucleic acids," Biochem. 16, 3647-3654 (1977).
[CrossRef]

Alfano, R. R.

Balembois, F.

Bente, E.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Bohaty, L.

H. Hellwig, J. Liebertz, and L. Bohaty, "Linear optical properties of the monoclinic bismuth borate BiB3O6," J. Appl. Phys. 88, 240-244 (2000).
[CrossRef]

H. Hellwig, J. Liebertz, and L. Bohaty, "Exceptional large nonlinear optical coefficients in the monoclinic bismuth borate BiB3O6," Solid State Commun. 109, 249-251 (1999).
[CrossRef]

Brunner, F.

Burns, D.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Danielius, R.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Delaigue, M.

Dörring, J.

Druon, F.

Du, C.

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

Ebrahim-Zadeh, M.

Fallnich, C.

Ferguson, A. I.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Forget, S.

Fu, K.

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

Fujimoto, J. G.

Fujita, M.

Gendron, N. H.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Georges, P.

Gharabaghi, F.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Ghotbi, M.

Giniunas, L.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Harimoto, T.

Haynes, N. K.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Hein, J.

G. Paunescu, J. Hein and R. Sauerbrey, "100-fs diode-pumped Yb:KGW mode-locked laser," Appl. Phys. B 79, 555-558 (2004).
[CrossRef]

Hellwig, H.

H. Hellwig, J. Liebertz, and L. Bohaty, "Linear optical properties of the monoclinic bismuth borate BiB3O6," J. Appl. Phys. 88, 240-244 (2000).
[CrossRef]

H. Hellwig, J. Liebertz, and L. Bohaty, "Exceptional large nonlinear optical coefficients in the monoclinic bismuth borate BiB3O6," Solid State Commun. 109, 249-251 (1999).
[CrossRef]

Hirakawa, Y.

Huber, G.

Ivanov, A.

Jantzi, S. C.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Jiang, H.

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

Kaertner, F. X.

Kearns, D. R.

J. Olmsted and D. R. Kearns, "Mechanism of ethidium bromide fluorescence enhancement on binding to nucleic acids," Biochem. 16, 3647-3654 (1977).
[CrossRef]

Killi, A.

Kityk, I. V.

Kolev, V. Z.

Kopf, D.

Kotoris, C. C.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Kowalevicz, A. M.

Krull, U. J.

P. A. E. Piunno and U. J. Krull, "Trends in the development of nucleic acid biosensors for medical diagnostics," Anal. Bioanal. Chem. 381, 1004-1011 (2005).
[CrossRef] [PubMed]

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Kuleshov, N. V.

Lagatsky, A. A.

Langford, N.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Lederer, M. J.

Lévêque-Fort, S.

Liang, X. C.

Liebertz, J.

H. Hellwig, J. Liebertz, and L. Bohaty, "Linear optical properties of the monoclinic bismuth borate BiB3O6," J. Appl. Phys. 88, 240-244 (2000).
[CrossRef]

H. Hellwig, J. Liebertz, and L. Bohaty, "Exceptional large nonlinear optical coefficients in the monoclinic bismuth borate BiB3O6," Solid State Commun. 109, 249-251 (1999).
[CrossRef]

Luther-Davies, B.

Mackenzie, A. E.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Majchrowski, A.

Major, A.

A. Major, L. Giniunas, N. Langford, A. I. Ferguson, D. Burns, E. Bente, and R. Danielius, "Saturable Bragg reflector-based continuous-wave mode locking of Yb:KGd(WO4)2 laser," J. Mod. Opt. 49, 787-793 (2002).
[CrossRef]

Michalski, E.

Mikhailov, V. P.

Minkovski, N. I.

G. I. Petrov, V. V. Yakovlev, N. I. Minkovski, "Broadband nonlinear optical conversion of a high-energy diode-pumped picosecond laser," Opt. Commun. 229, 441-445 (2004).
[CrossRef]

Morgner, U.

Olmsted, J.

J. Olmsted and D. R. Kearns, "Mechanism of ethidium bromide fluorescence enhancement on binding to nucleic acids," Biochem. 16, 3647-3654 (1977).
[CrossRef]

Papadopoulos, D. N.

Paschotta, R.

R. Paschotta, J. Aus der Au, G. J. Spühler, F. Morier-Genoud, R.Hövel, M. Moser, S. Erhard, M. Karszewski, A. Giesen, and U. Keller, "Diode-pumped passively mode-locked lasers with high average power," Appl. Phys. B 70, S25-S31 (2000).
[CrossRef]

Paunescu, G.

G. Paunescu, J. Hein and R. Sauerbrey, "100-fs diode-pumped Yb:KGW mode-locked laser," Appl. Phys. B 79, 555-558 (2004).
[CrossRef]

Paye, J.

Petrov, G. I.

G. I. Petrov, V. V. Yakovlev, N. I. Minkovski, "Broadband nonlinear optical conversion of a high-energy diode-pumped picosecond laser," Opt. Commun. 229, 441-445 (2004).
[CrossRef]

Piunno, P. A. E.

P. A. E. Piunno and U. J. Krull, "Trends in the development of nucleic acid biosensors for medical diagnostics," Anal. Bioanal. Chem. 381, 1004-1011 (2005).
[CrossRef] [PubMed]

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Podlipensky, A. V.

Prasankumar, R. P.

Raha, S.

J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Ramaswamy, M.

Rode, A. V.

Sauerbrey, R.

G. Paunescu, J. Hein and R. Sauerbrey, "100-fs diode-pumped Yb:KGW mode-locked laser," Appl. Phys. B 79, 555-558 (2004).
[CrossRef]

Schiller, N. H.

Shao, Z.

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

Shcheslavskiy, V.

Song, R.

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J. H. Watterson, S. Raha, C. C. Kotoris, C. C. Wust, F. Gharabaghi, S. C. Jantzi, N. K. Haynes, N. H. Gendron, U. J. Krull, A. E. Mackenzie and P. A. E. Piunno, "Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor," Nucl. Acids Res. 32, e18 (2004).
[CrossRef] [PubMed]

Opt. Commun.

Z. Wang, B. Teng, K. Fu, X. Xu, R. Song, C. Du, H. Jiang, J. Wang, and Z. Shao, "Efficient second harmonic generation of pulsed laser radiation in BiB3O6 (BIBO) crystal with different phase matching directions," Opt. Commun. 202,217-220 (2002).
[CrossRef]

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Opt. Express

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M. Ghotbi, M. Ebrahim-Zadeh, A. Majchrowski, E. Michalski, and I. V. Kityk, "High-average-power femtosecond pulse generation in the blue using BiB3O6," Opt. Lett. 29, 2530-2532 (2004).
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Figures (6)

Fig. 1.
Fig. 1.

Schematic design of an extended cavity femtosecond Yb:KGW laser operating at a repetition rate of 15 MHz. Please see text for the details.

Fig. 2.
Fig. 2.

The train of pulses at 15 MHz measured with a fast photodiode (a) and the optical spectrum of ~200 fs pulses (b).

Fig. 3.
Fig. 3.

The spectrum of the second harmonic.

Fig. 4.
Fig. 4.

Test lifetime measurements of ethidium bromide.

Fig. 5.
Fig. 5.

A diagram of an optical DNA sensor. EB - ethidium bromide.

Fig. 6.
Fig. 6.

Thermal denaturation studies of the SMN2 sensor.

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