The solid-state intramolecular cyclization of lisinopril to diketopiperazine was investigated by <i>in situ</i> Fourier transform infrared (FT-IR) microscopy. Using a controllable heating cell, the isothermal transformation was monitored <i>in situ</i> at 147.5, 150, 152.5, 155, and 157.5 °C. The collected time-dependent FT-IR spectra at each isothermal temperature were preprocessed and analyzed using a multivariate chemometric approach. The pure component spectra of the observable component (lisinopril and diketopiperazine) were resolved and their time-dependent relative contributions were also determined. Model-free and various model fitting methods were implemented in the kinetic analysis to estimate the activation energy of the intramolecular cyclization reaction. Arrhenius plots indicate that the activation energy is circa 327 kJ/mol.
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
Login to access OSA Member Subscription