Abstract

Water contamination in dimethyl sulfoxide (DMSO) compound libraries is a recognized problem in the pharmaceutical industry. We describe a nondestructive, near-infrared (NIR) assay for water contamination inside the sealed containers used for compound libraries. This assay does not require opening the containers. We also report our observation of the permeation of water from laboratory air through the sealed container and into the DMSO solution over a period of months, as well as the rate of water absorption by DMSO directly exposed to laboratory air.

PDF Article

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.