Abstract

High-resolution absorption spectra of gas-phase monomethylamine (MMA, CH3NH2) and dimethylamine [DMA, (CH3)2NH] in the region of the first overtone of the NH stretch vibration are reported. Measurements were performed with a near-infrared laser spectrometer based on the cavity-ringdown (CRD) detection technique. The minimum detectable absorption coefficient for the CRD detection setup is αmin=1.55×108cm1 (for SNR = 1). This corresponds to detection limits of 350 parts in 109 (ppb) for MMA and 1.6 parts in 106 (ppm) for DMA in synthetic gas mixtures under interference-free conditions, or 10 ppm and 60 ppm for MMA and DMA, respectively, in the case of gas mixtures such as exhaled human breath containing H 2O, CO2, and other absorbing gases in this range.

© 2007 Optical Society of America

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    [CrossRef] [PubMed]
  2. S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
    [CrossRef] [PubMed]
  3. A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
    [CrossRef]
  4. S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
    [CrossRef] [PubMed]
  5. S. A. Kharitonov and P. J. Barnes, "Exhaled Markers of Pulmonary Disease," Am. J. Respir. Crit. Care Med. 163, 1693-1722 (2001).
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  6. G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
    [PubMed]
  7. A. Kosterev and F. Tittel, "Chemical sensors based on quantum cascade lasers," IEEE J. Quantum Electron. 38, 582-591 (2002).
    [CrossRef]
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    [CrossRef] [PubMed]
  10. S. C. Mitchell and A. Q. Zhang, "Methylamine in human urine," Clin. Chim. Acta 312, 107-114 (2001).
    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
  13. I. B. C. Matheson, "The method of successive integration-a general technique for recasting kinetic equations in a readily soluble form which is linear in the coefficients and sufficiently rapid for real-time instrumental use," Anal. Instrum. 16, 345-373 (1987).
    [CrossRef]
  14. D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
    [CrossRef]
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    [CrossRef]
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    [CrossRef]
  17. J. Morville, D. Romanini, M. Chenevier, and A. Kachanov, "Effects of laser phase noise on the injection of a high-finesse cavity," Appl. Opt. 41, 6980-6990 (2002).
    [CrossRef] [PubMed]
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    [CrossRef]

2006 (1)

D. E. Vogler and M. W. Sigrist, "Near-infrared laser based cavity ringdown spectroscopy for applications in petrochemical industry," Appl. Phys. B 85, 349-354 (2006).
[CrossRef]

2005 (1)

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

2004 (2)

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

2003 (1)

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

2002 (3)

A. Kosterev and F. Tittel, "Chemical sensors based on quantum cascade lasers," IEEE J. Quantum Electron. 38, 582-591 (2002).
[CrossRef]

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

J. Morville, D. Romanini, M. Chenevier, and A. Kachanov, "Effects of laser phase noise on the injection of a high-finesse cavity," Appl. Opt. 41, 6980-6990 (2002).
[CrossRef] [PubMed]

2001 (3)

S. C. Mitchell and A. Q. Zhang, "Methylamine in human urine," Clin. Chim. Acta 312, 107-114 (2001).
[CrossRef] [PubMed]

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

S. A. Kharitonov and P. J. Barnes, "Exhaled Markers of Pulmonary Disease," Am. J. Respir. Crit. Care Med. 163, 1693-1722 (2001).
[PubMed]

1997 (1)

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

1996 (1)

K. L. Moskalenko, A. I. Nadezhdinskii, and I. A. Adamovskaya, "Human breath trace gas content study by tunable diode laser spectroscopy technique," Infrared Phys. Technol. 37, 181-192 (1996).
[CrossRef]

1995 (1)

P. Zalicki and R. N. Zare, "Cavity ringdown spectroscopy for quantitative absorption-measurements," J. Chem. Phys. 102, 2708-2717 (1995).
[CrossRef]

1992 (1)

M. Phillips, "Breath tests in medicine," Sci. Am. 267, 74-79 (1992).
[CrossRef] [PubMed]

1987 (1)

I. B. C. Matheson, "The method of successive integration-a general technique for recasting kinetic equations in a readily soluble form which is linear in the coefficients and sufficiently rapid for real-time instrumental use," Anal. Instrum. 16, 345-373 (1987).
[CrossRef]

1984 (1)

H. L. Fang, R. L. Swofford, and D. A. C. Compton, "Overtone absorption spectra of gaseous amines: CH3NH2, (CH3)2NH, Et2NH, and N2H4. Conformationally non-equivalent C-H and N-H local mode oscillators," Chem. Phys. Lett. 108, 539-546 (1984).
[CrossRef]

1977 (1)

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Adamovskaya, I. A.

K. L. Moskalenko, A. I. Nadezhdinskii, and I. A. Adamovskaya, "Human breath trace gas content study by tunable diode laser spectroscopy technique," Infrared Phys. Technol. 37, 181-192 (1996).
[CrossRef]

Amann, A.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Barbe, A.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Barnes, P. J.

S. A. Kharitonov and P. J. Barnes, "Exhaled Markers of Pulmonary Disease," Am. J. Respir. Crit. Care Med. 163, 1693-1722 (2001).
[PubMed]

Becker, P. B.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Benner, D. C.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Birk, M.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Brown, L. R.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Burdick, J. F.

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

Burke, J. F.

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Carleer, M. R.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Chackerian, C.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Chance, K.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Chenevier, M.

Compton, D. A. C.

H. L. Fang, R. L. Swofford, and D. A. C. Compton, "Overtone absorption spectra of gaseous amines: CH3NH2, (CH3)2NH, Et2NH, and N2H4. Conformationally non-equivalent C-H and N-H local mode oscillators," Chem. Phys. Lett. 108, 539-546 (1984).
[CrossRef]

Conte, J. V.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Cope, K. A.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Coudert, L. H.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Dahnke, H.

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

Dana, V.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Devi, V. M.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Doty, R.

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Fang, H. L.

H. L. Fang, R. L. Swofford, and D. A. C. Compton, "Overtone absorption spectra of gaseous amines: CH3NH2, (CH3)2NH, Et2NH, and N2H4. Conformationally non-equivalent C-H and N-H local mode oscillators," Chem. Phys. Lett. 108, 539-546 (1984).
[CrossRef]

Flaud, J. M.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Gamache, R. R.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Goldman, A.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Halmer, D.

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

Hartmann, J. M.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Hering, P.

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

Jacquemart, D.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Jiang, L.

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

Jucks, K. W.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Kachanov, A.

Kachanov, A. A.

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

Kharitonov, S. A.

S. A. Kharitonov and P. J. Barnes, "Exhaled Markers of Pulmonary Disease," Am. J. Respir. Crit. Care Med. 163, 1693-1722 (2001).
[PubMed]

Kosterev, A.

A. Kosterev and F. Tittel, "Chemical sensors based on quantum cascade lasers," IEEE J. Quantum Electron. 38, 582-591 (2002).
[CrossRef]

Krishnan, J. A.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Ledochowski, M.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Maki, A. G.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Mandin, J. Y.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Massie, S. T.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Matheson, I. B. C.

I. B. C. Matheson, "The method of successive integration-a general technique for recasting kinetic equations in a readily soluble form which is linear in the coefficients and sufficiently rapid for real-time instrumental use," Anal. Instrum. 16, 345-373 (1987).
[CrossRef]

Mechtcheriakov, S.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Mitchell, S. C.

S. C. Mitchell and A. Q. Zhang, "Methylamine in human urine," Clin. Chim. Acta 312, 107-114 (2001).
[CrossRef] [PubMed]

Morville, J.

Moskalenko, K. L.

K. L. Moskalenko, A. I. Nadezhdinskii, and I. A. Adamovskaya, "Human breath trace gas content study by tunable diode laser spectroscopy technique," Infrared Phys. Technol. 37, 181-192 (1996).
[CrossRef]

Mürtz, M.

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

Nadezhdinskii, A. I.

K. L. Moskalenko, A. I. Nadezhdinskii, and I. A. Adamovskaya, "Human breath trace gas content study by tunable diode laser spectroscopy technique," Infrared Phys. Technol. 37, 181-192 (1996).
[CrossRef]

Ordinario, A. T.

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Orens, J. B.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Orphal, J.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Perrin, A.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Phillips, M.

M. Phillips, "Breath tests in medicine," Sci. Am. 267, 74-79 (1992).
[CrossRef] [PubMed]

Poupart, G.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Rinsland, C. P.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Risby, T. H.

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Romanini, D.

J. Morville, D. Romanini, M. Chenevier, and A. Kachanov, "Effects of laser phase noise on the injection of a high-finesse cavity," Appl. Opt. 41, 6980-6990 (2002).
[CrossRef] [PubMed]

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

Rosas, I.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Rothman, L. S.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Saukkonen, J. J.

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Schmid, A.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Sedghi, N.

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

Sehnert, S. S.

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

Sigrist, M. W.

D. E. Vogler and M. W. Sigrist, "Near-infrared laser based cavity ringdown spectroscopy for applications in petrochemical industry," Appl. Phys. B 85, 349-354 (2006).
[CrossRef]

Simenhoff, M. L.

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Smith, M. A. H.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Stoeckel, F.

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

Studer, S. M.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Swofford, R. L.

H. L. Fang, R. L. Swofford, and D. A. C. Compton, "Overtone absorption spectra of gaseous amines: CH3NH2, (CH3)2NH, Et2NH, and N2H4. Conformationally non-equivalent C-H and N-H local mode oscillators," Chem. Phys. Lett. 108, 539-546 (1984).
[CrossRef]

Telser, S.

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

Tennyson, J.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Tittel, F.

A. Kosterev and F. Tittel, "Chemical sensors based on quantum cascade lasers," IEEE J. Quantum Electron. 38, 582-591 (2002).
[CrossRef]

Tolchenov, R. N.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Toth, R. A.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Vander Auwera, J.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Varanasi, P.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Vogler, D. E.

D. E. Vogler and M. W. Sigrist, "Near-infrared laser based cavity ringdown spectroscopy for applications in petrochemical industry," Appl. Phys. B 85, 349-354 (2006).
[CrossRef]

von Basum, G.

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

Wagner, G.

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

Yang, S.

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

Zalicki, P.

P. Zalicki and R. N. Zare, "Cavity ringdown spectroscopy for quantitative absorption-measurements," J. Chem. Phys. 102, 2708-2717 (1995).
[CrossRef]

Zare, R. N.

P. Zalicki and R. N. Zare, "Cavity ringdown spectroscopy for quantitative absorption-measurements," J. Chem. Phys. 102, 2708-2717 (1995).
[CrossRef]

Zhang, A. Q.

S. C. Mitchell and A. Q. Zhang, "Methylamine in human urine," Clin. Chim. Acta 312, 107-114 (2001).
[CrossRef] [PubMed]

Am. J. Respir. Crit. Care Med. (1)

S. A. Kharitonov and P. J. Barnes, "Exhaled Markers of Pulmonary Disease," Am. J. Respir. Crit. Care Med. 163, 1693-1722 (2001).
[PubMed]

Anal. Instrum. (1)

I. B. C. Matheson, "The method of successive integration-a general technique for recasting kinetic equations in a readily soluble form which is linear in the coefficients and sufficiently rapid for real-time instrumental use," Anal. Instrum. 16, 345-373 (1987).
[CrossRef]

Appl. Opt. (1)

Appl. Phys. B (1)

D. E. Vogler and M. W. Sigrist, "Near-infrared laser based cavity ringdown spectroscopy for applications in petrochemical industry," Appl. Phys. B 85, 349-354 (2006).
[CrossRef]

Biomarkers (1)

S. S. Sehnert, L. Jiang, J. F. Burdick, and T. H. Risby, "Breath biomarkers for detection of human liver diseases: preliminary study," Biomarkers 7, 174-187 (2002).
[CrossRef] [PubMed]

Chem. Phys. Lett. (2)

D. Romanini, A. A. Kachanov, N. Sedghi, and F. Stoeckel, "CW cavity ringdown spectroscopy," Chem. Phys. Lett. 264, 316-322 (1997).
[CrossRef]

H. L. Fang, R. L. Swofford, and D. A. C. Compton, "Overtone absorption spectra of gaseous amines: CH3NH2, (CH3)2NH, Et2NH, and N2H4. Conformationally non-equivalent C-H and N-H local mode oscillators," Chem. Phys. Lett. 108, 539-546 (1984).
[CrossRef]

Clin. Chim. Acta (1)

S. C. Mitchell and A. Q. Zhang, "Methylamine in human urine," Clin. Chim. Acta 312, 107-114 (2001).
[CrossRef] [PubMed]

IEEE J. Quantum Electron. (1)

A. Kosterev and F. Tittel, "Chemical sensors based on quantum cascade lasers," IEEE J. Quantum Electron. 38, 582-591 (2002).
[CrossRef]

Infrared Phys. Technol. (1)

K. L. Moskalenko, A. I. Nadezhdinskii, and I. A. Adamovskaya, "Human breath trace gas content study by tunable diode laser spectroscopy technique," Infrared Phys. Technol. 37, 181-192 (1996).
[CrossRef]

Int. J. Mass. Spectrom. (1)

A. Amann, G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine," Int. J. Mass. Spectrom. 239, 227-233 (2004).
[CrossRef]

J. Appl. Physiol. (1)

G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Mürtz, "Online recording of ethane traces in human breath via infrared laser spectroscopy," J. Appl. Physiol. 95, 2583-2590 (2003).
[PubMed]

J. Chem. Phys. (1)

P. Zalicki and R. N. Zare, "Cavity ringdown spectroscopy for quantitative absorption-measurements," J. Chem. Phys. 102, 2708-2717 (1995).
[CrossRef]

J. Heart Lung Transplant (1)

S. M. Studer, J. B. Orens, I. Rosas, J. A. Krishnan, K. A. Cope, S. Yang, J. V. Conte, P. B. Becker, and T. H. Risby, "Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection," J. Heart Lung Transplant 20, 1158-1166 (2001).
[CrossRef] [PubMed]

J. Quant. Spectrosc. Radiat. Transfer (1)

L. S. Rothman, D. Jacquemart, A. Barbe, D. C. Benner, M. Birk, L. R. Brown, M. R. Carleer, C. Chackerian, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, J. M. Flaud, R. R. Gamache, A. Goldman, J. M. Hartmann, K. W. Jucks, A. G. Maki, J. Y. Mandin, S. T. Massie, J. Orphal, A. Perrin, C. P. Rinsland, M. A. H. Smith, J. Tennyson, R. N. Tolchenov, R. A. Toth, J. Vander Auwera, P. Varanasi, and G. Wagner, "The HITRAN 2004 molecular spectroscopic database," J. Quant. Spectrosc. Radiat. Transfer 96, 139-2044 (2005).
[CrossRef]

N. Engl. J. Med. (1)

M. L. Simenhoff, J. F. Burke, J. J. Saukkonen, A. T. Ordinario, and R. Doty, "Biochemical profile of uremic breath," N. Engl. J. Med. 297, 132-135 (1977).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

D. Halmer, G. von Basum, P. Hering, and M. Mürtz, "Fast exponential fitting algorithm for real-time instrumental use," Rev. Sci. Instrum. 75, 2187-2190 (2004).
[CrossRef]

Sci. Am. (1)

M. Phillips, "Breath tests in medicine," Sci. Am. 267, 74-79 (1992).
[CrossRef] [PubMed]

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Figures (5)

Fig. 1
Fig. 1

Schematic setup of the NIR spectroscopic system with two detection schemes: (a) ratiometric absorption detection scheme and (b) CRD detection scheme. ECDL, external cavity diode laser; BS, beam splitter; V, valve; GC, gas preparation chamber; L 1 L 4 , lenses; PD, photodiode; SR 510, SR 530, lock-in amplifiers; AOM, acousto-optic modulator; PZT, piezoelectric transducer; OS, oscilloscope; FG, voltage function generator.

Fig. 2
Fig. 2

Survey scans of MMA (a) taken by the ratiometric absorption detection scheme at different pressures and room temperature and (b) taken by the CRD detection scheme at 920 mbars total pressure and a concentration of 10.1 ppm. Solid line, reference absorption profile of 675 ppm H 2 O according to HITRAN [16]. Vertical lines represent the characteristic absorption features of MMA.

Fig. 3
Fig. 3

Survey scans of DMA (a) taken by the ratiometric absorption detection scheme at different pressures and room temperature and (b) taken by the CRD detection scheme at 920 mbars total pressure and a concentration of 62.9 ppm. Solid line, reference absorption profile of 500 ppm H 2 O according to HITRAN [16]. Vertical line represents the characteristic absorption feature of DMA.

Fig. 4
Fig. 4

Absorption profile of 10.1 ppm MMA buffered in N 2 and 675 ppm H 2 O at a total pressure of 920 mbars and room temperature. (a) Measured data and ADSF fit plus H 2 O absorption profile calculated with HITRAN [16] and (b) data points with subtracted H 2 O absorption profile and ADSF.

Fig. 5
Fig. 5

Absorption profile of 62.9 ppm DMA buffered in N 2 and 500 ppm H 2 O at a total pressure of 920 mbars and room temperature. (a) Measured data and ADSF fit plus H 2 O absorption profile calculated with HITRAN [16] and (b) data points with subtracted H 2 O absorption profile and ADSF.

Tables (1)

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Table 1 Detection Limits of Methylamines in Different Gas Mixtures (SNR = 1)

Equations (2)

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c x = V sol d sol c x , sol M r x R T p V ,
α ( v ) = α 0 + A · 1 1 + e v v c w 1 ( 1 1 1 + e v v c w 2 ) .

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