Abstract

A high-resolution liquid-nitrogen-free mid-infrared tunable diode laser absorption spectroscopy (TDLAS) system was used to perform real-time measurement of acetaldehyde concentrations in human exhaled breath following ingestion of an alcoholic beverage. Acetaldehyde absorption features were measured near 5.79μm(1727cm1) using a IV–VI semiconductor laser, a 100  m long path optical gas cell, and second- harmonic detection coupled with wavelength modulation. Acetaldehyde levels were measured with a minimum detection limit of 80 ppb for 5 s integration time. The variations in exhaled acetaldehyde levels over time were analyzed prior to and following ingestion of two different amounts of white wine. A method to calibrate acetaldehyde measurements internally using water vapor absorption lines was investigated to eliminate the need for system calibration with gas standards. The potential of a TDLAS system to be used as a noninvasive clinical tool for measurements of large volatile compounds with possible applications in cancer detection is demonstrated.

© 2007 Optical Society of America

Full Article  |  PDF Article
Related Articles
Simultaneous NO and CO2 measurement in human breath with a single IV–VI mid-infrared laser

C. Roller, K. Namjou, J. Jeffers, W. Potter, P. J. McCann, and J. Grego
Opt. Lett. 27(2) 107-109 (2002)

Nitric oxide breath testing by tunable-diode laser absorption spectroscopy: application in monitoring respiratory inflammation

Chad Roller, Khosrow Namjou, James D. Jeffers, Mark Camp, Adam Mock, Patrick J. McCann, and Joe Grego
Appl. Opt. 41(28) 6018-6029 (2002)

Pulsed quantum-cascade laser-based sensor for trace-gas detection of carbonyl sulfide

Gerard Wysocki, Matt McCurdy, Stephen So, Damien Weidmann, Chad Roller, Robert F. Curl, and Frank K. Tittel
Appl. Opt. 43(32) 6040-6046 (2004)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (10)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription