Abstract

The Mueller matrix describes all the polarizing properties of a sample and, therefore, the optical differences between noncancerous and precancerous tissue that may be present within the matrix elements. A high-speed polarimetry system that generates 16 (4×4) full Mueller matrices to characterize tissues is presented. Feature extraction is done on the Mueller matrix elements resulting in depolarization and retardance images by polar decomposition. These are used to detect and classify early oral cancers and precancerous changes in epithelium such as dysplasia. These images are compared with orthogonal polarization images and analyzed in an attempt to identity useful factors for the differentiation between cancerous lesions and their benign counterparts. Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy.

© 2007 Optical Society of America

Full Article  |  PDF Article
Related Articles
Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model

Lezlee Coghlan, Urs Utzinger, Rebekah Drezek, Douglas Heintzelman, Andres Zuluaga, Carrie Brookner, Rebecca Richards-Kortum, Irma Gimenez-Conti, and Michele Follen
Opt. Express 7(12) 436-446 (2000)

Multispectral digital microscopy for in vivo monitoring of oral neoplasia in the hamster cheek pouch model of carcinogenesis

Sun Young Park, Tom Collier, Jesse Aaron, Mia K. Markey, Rebecca Richards-Kortum, Konstantin Sokolov, Nick Mackinnon, Calum MacAulay, Lezlee Coghlan, Andrea Milbourne, and Michele Follen
Opt. Express 13(3) 749-762 (2005)

Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy

Melissa C. Skala, Gregory M. Palmer, Kristin M. Vrotsos, Annette Gendron-Fitzpatrick, and Nirmala Ramanujam
Opt. Express 15(12) 7863-7875 (2007)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (18)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription