Abstract

An experimental setup for combined photoacoustic (PA) and optically mediated ultrasound (US) microscopy is presented. A spherically focused 35 MHz polyvinylidene fluoride (PVDF) ultrasonic detector with a numerical aperture of 0.28, a focal distance of 9 mm, and a bandwidth (6dB level) of 24 MHz was used to obtain PA and US data with a 3 mm imaging depth. A fiber-optic system was employed to deliver laser excitation pulses from a tunable laser to the studied medium. A single optical pulse was used to form both PA and US A-scans. The probing US pulses were generated thermoelastically due to absorption of backscattered laser radiation by the metalized surface of a PVDF film.

© 2012 Optical Society of America

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L.-H. V. Wang and S. Hu, Science 335, 1458 (2012).
[CrossRef]

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, Opt. Express 20, 1588 (2012).
[CrossRef]

2011 (4)

J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. van Hespen, C. H. Slump, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
[CrossRef]

J. Powers and F. Kremkau, Interface Focus 1, 477 (2011).
[CrossRef]

D. S. Kopylova and I. M. Pelivanov, J. Acoust. Soc. Am. 130, EL213 (2011).
[CrossRef]

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

2010 (2)

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

K. Passler, R. Nuster, S. Gratt, P. Burgholzer, T. Berer, and G. Paltauf, Biomed. Opt. Express 1, 318 (2010).
[CrossRef]

2009 (1)

2008 (1)

2006 (1)

2005 (2)

K. Maslov, G. Stoica, and L. V. Wang, Opt. Lett. 30, 625 (2005).
[CrossRef]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Aglyamov, S. R.

Ashkenazi, S.

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Baac, H. W.

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Beard, P.

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

Berer, T.

Burgholzer, P.

Chen, S. L.

Emelianov, S. Y.

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

S. Park, A. B. Karpiouk, S. R. Aglyamov, and S. Y. Emelianov, Opt. Lett. 33, 1291 (2008).
[CrossRef]

Esenaliev, R. O.

Forbrich, A.

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Gratt, S.

Guo, L. J.

B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, Opt. Express 20, 1588 (2012).
[CrossRef]

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Harisson, T.

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

Hsieh, B. Y.

Hu, S.

L.-H. V. Wang and S. Hu, Science 335, 1458 (2012).
[CrossRef]

Huang, S.-W.

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Jiang, Y.

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

Jose, J.

Karpiouk, A. B.

Kopylova, D. S.

D. S. Kopylova and I. M. Pelivanov, J. Acoust. Soc. Am. 130, EL213 (2011).
[CrossRef]

Kremkau, F.

J. Powers and F. Kremkau, Interface Focus 1, 477 (2011).
[CrossRef]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Li, P. C.

Ling, T.

B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, Opt. Express 20, 1588 (2012).
[CrossRef]

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Manohar, S.

Maslov, K.

Nam, S. Y.

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Nuster, R.

Paltauf, G.

Park, S.

Passler, K.

Patrikeev, I. A.

Pelivanov, I. M.

D. S. Kopylova and I. M. Pelivanov, J. Acoust. Soc. Am. 130, EL213 (2011).
[CrossRef]

Petrov, Y. Y.

Petrova, I. Y.

Piras, D.

Powers, J.

J. Powers and F. Kremkau, Interface Focus 1, 477 (2011).
[CrossRef]

Prough, D. S.

Resink, S.

Ricles, L. M.

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

Slump, C. H.

Steenbergen, W.

Stoica, G.

Suggs, L. J.

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

van Hespen, J. C. G.

van Leeuwen, T. G.

Wang, L. V.

Wang, L.-H. V.

L.-H. V. Wang and S. Hu, Science 335, 1458 (2012).
[CrossRef]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Willemink, R. G. H.

Xie, Z.

Zemp, R. J.

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

Zhang, H. F.

Appl. Opt. (1)

Biomed. Opt. Express (1)

IEEE Trans. Med. Imaging (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436 (2005).
[CrossRef]

Interface Focus (2)

J. Powers and F. Kremkau, Interface Focus 1, 477 (2011).
[CrossRef]

P. Beard, Interface Focus 1, 602 (2011).
[CrossRef]

J. Acoust. Soc. Am. (1)

D. S. Kopylova and I. M. Pelivanov, J. Acoust. Soc. Am. 130, EL213 (2011).
[CrossRef]

J. Biomed. Opt. (1)

Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17, 036012 (2012).
[CrossRef]

Opt. Express (2)

Opt. Lett. (3)

PLoS ONE (1)

S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Emelianov, PLoS ONE 7, e37267 (2012).
[CrossRef]

Proc. Soc. Photo-Opt. Instrum. Eng. (1)

H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo-Opt. Instrum. Eng. 7564, 75642M (2010).
[CrossRef]

Science (1)

L.-H. V. Wang and S. Hu, Science 335, 1458 (2012).
[CrossRef]

Other (1)

American National Standards Institute (ANSI), “American national standard for the safe use of lasers,” Standard Z136.1-2007 (Laser Institute of America, Orlando, FL, 2007).

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Figures (4)

Fig. 1.
Fig. 1.

PA/US dual-modality microscope. (a) Scheme of the developed setup, (b) photography of cylindrical contrast agents used in experiments, (c) time of acquisition for the latest PA and earliest US pulses at the depth d using an acoustic sensor focused at F.

Fig. 2.
Fig. 2.

A-scan containing PA and US signals from the copper wire in an agar gel phantom normalized to the amplitude of the detector’s laser excitation.

Fig. 3.
Fig. 3.

PA/US B-scans of contrast objects oriented along the Y axis at a depth of 2 mm in the agar gel phantom. (a) PA image; (b) distribution of contrast agents inside phantom: (1) 65 μm copper wires, (2) 125 μm quartz glass fiber; (3) 90 μm translucent PVDF line, (4) 90 μm colored PVDF line; (c) US image. Red curves are PA and US signal profiles along the X axis; black curves are PA and US signal profiles along the Z axis.

Fig. 4.
Fig. 4.

US/PA [(a),(c)/(b),(d)] images of same area of agar phantom including five copper wires 65 μm in diameter with a spacing of 500 μm. (a), (b) B-scans perpendicular to the copper wires, (c), (d) C-scans through the centers of the B-scans. Step resolution in the XY plane is 30 μm.

Equations (1)

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d<F1+cW/c,

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