Abstract

We report the development of a frequency-domain biomedical photoacoustic imaging system that utilizes a continuous-wave laser source with a custom intensity modulation pattern, ultrasonic phased array for signal detection, and processing coupled with a beam-forming algorithm for reconstruction of photoacoustic correlation images. Sensitivity to optical contrast was demonstrated using tissue-mimicking phantoms and in-vivo tissue samples.

© 2011 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
    [CrossRef]
  2. R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
    [CrossRef] [PubMed]
  3. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
    [CrossRef] [PubMed]
  4. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
    [CrossRef]
  5. R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
    [CrossRef]
  6. R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, Opt. Express 16, 18551 (2008).
    [CrossRef] [PubMed]
  7. A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
    [CrossRef]
  8. S. Telenkov and A. Mandelis, J. Appl. Phys. 105, 102029-1(2009).
    [CrossRef]
  9. S. Telenkov and A. Mandelis, J. Biomed. Opt. 14, 044025-1(2009).
    [CrossRef]
  10. C. E. Cook and M. Bernfeld, Radar Signals. An Introduction to Theory and Application (Academic, 1967).
  11. S. Telenkov and A. Mandelis, Rev. Sci. Instrum. 81, 124901-1 (2010).
    [CrossRef]
  12. G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
    [CrossRef] [PubMed]
  13. American National Standard, ANSI Z136.1-200777.

2010 (1)

S. Telenkov and A. Mandelis, Rev. Sci. Instrum. 81, 124901-1 (2010).
[CrossRef]

2009 (4)

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

S. Telenkov and A. Mandelis, J. Appl. Phys. 105, 102029-1(2009).
[CrossRef]

S. Telenkov and A. Mandelis, J. Biomed. Opt. 14, 044025-1(2009).
[CrossRef]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

2008 (3)

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, Opt. Express 16, 18551 (2008).
[CrossRef] [PubMed]

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

2006 (1)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

2005 (1)

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

1999 (1)

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Aguirre, A.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Bernfeld, M.

C. E. Cook and M. Bernfeld, Radar Signals. An Introduction to Theory and Application (Academic, 1967).

Bitton, R.

Brands, P. J.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

Brewer, M.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Cook, C. E.

C. E. Cook and M. Bernfeld, Radar Signals. An Introduction to Theory and Application (Academic, 1967).

Dorschel, K.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Friebel, M.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Gamelin, J.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Glade, C. P.

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

Guo, P.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Hahn, A.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Kolkman, R. G. M.

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Leonard, M.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Mandelis, A.

S. Telenkov and A. Mandelis, Rev. Sci. Instrum. 81, 124901-1 (2010).
[CrossRef]

S. Telenkov and A. Mandelis, J. Biomed. Opt. 14, 044025-1(2009).
[CrossRef]

S. Telenkov and A. Mandelis, J. Appl. Phys. 105, 102029-1(2009).
[CrossRef]

Maslov, K.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

Mulder, M. J.

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

Muller, G.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Oraevsky, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

Roggan, A.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Sanders, M.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Shung, K. K.

Song, L.

Spirou, G.

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

Steenbergen, W.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

Stoica, G.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Telenkov, S.

S. Telenkov and A. Mandelis, Rev. Sci. Instrum. 81, 124901-1 (2010).
[CrossRef]

S. Telenkov and A. Mandelis, J. Appl. Phys. 105, 102029-1(2009).
[CrossRef]

S. Telenkov and A. Mandelis, J. Biomed. Opt. 14, 044025-1(2009).
[CrossRef]

Van Leeuwen, T. G.

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

Vitkin, I. A.

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

Wang, L. V.

Whealan, W.

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

Yan, S.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

Zemp, R. J.

Zhang, H. F.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Zu, Q.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

J. Appl. Phys. (1)

S. Telenkov and A. Mandelis, J. Appl. Phys. 105, 102029-1(2009).
[CrossRef]

J. Biomed. Opt. (5)

S. Telenkov and A. Mandelis, J. Biomed. Opt. 14, 044025-1(2009).
[CrossRef]

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zu, J. Biomed. Opt. 14, 054014-1 (2009).
[CrossRef]

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. Oraevsky, J. Biomed. Opt. 14, 024007-1 (2009).
[CrossRef]

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, J. Biomed. Opt. 13, 050510-1 (2008).
[CrossRef]

Lasers Surg. Med. (1)

R. G. M. Kolkman, M. J. Mulder, C. P. Glade, W. Steenbergen, and T. G. Van Leeuwen, Lasers Surg. Med. 40, 178 (2008).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006).
[CrossRef] [PubMed]

Opt. Express (1)

Phys. Med. Biol. (1)

G. Spirou, A. Oraevsky, I. A. Vitkin, and W. Whealan, Phys. Med. Biol. 50, N141 (2005).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

S. Telenkov and A. Mandelis, Rev. Sci. Instrum. 81, 124901-1 (2010).
[CrossRef]

Other (2)

C. E. Cook and M. Bernfeld, Radar Signals. An Introduction to Theory and Application (Academic, 1967).

American National Standard, ANSI Z136.1-200777.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1
Fig. 1

Schematic of frequency-domain PA imager (left) and system setup for in-vivo imaging (right).

Fig. 2
Fig. 2

System PSF computed using array parameters and simulated point sources (a) and measured using cotton threads imbedded in a PVC phantom (b). The vertical scale bar is 1 cm long.

Fig. 3
Fig. 3

Ultrasound image (a) and PA probe image (b) of the PVC phantom with a subsurface inclusion. Image of discrete chromophores (c) immersed in Intralipid solution and blood vessels in a human wrist (d). The vertical scale bar is 1 cm long.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

B i ( t τ ) = 1 2 π + S r * ( ω ) S i ( ω ) e i ω ( t τ ) d ω .
u ( t , θ ) = i = 0 N 1 w i · B i ( t x i c a sin θ ) ,

Metrics