Abstract

We demonstrate an endoscope-compatible single-fiber-based device that performs simultaneous confocal microscopy and high-precision laser microsurgery. The method is based on mapping of two-dimensional sample coordinates onto the optical spectrum and allows us to perform two-dimensional imaging and microsurgery without any mechanical movement of the probe or the sample. The technology holds promise for creating highly miniaturized endoscopes for applications such as brain tumor, pediatric, and endovascular surgeries where high-precision, small, and flexible probes are required.

© 2009 Optical Society of America

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2009 (1)

K. Goda, K. K. Tsia, and B. Jalali, Nature 458, 1145 (2009).
[CrossRef] [PubMed]

2008 (3)

2007 (1)

S. A. Diddams, L. Hollberg, and V. Mbele, Nature 445, 627 (2007).
[CrossRef] [PubMed]

2006 (1)

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

2004 (1)

2001 (1)

1996 (1)

1993 (1)

Aziz, D.

Balslev-Clausen, D.

Barretto, R. P. J.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Ben-Yakar, A.

Bouma, B. E.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Burn, L. D.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Charboneau, J. W.

C. Rumack, S. Wilson, J. W. Charboneau, and J.-A. Johnson, Diagnostic Ultrasound (Mosby, 2004).

Chen, P.

Cocker, E. D.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Diddams, S. A.

S. A. Diddams, L. Hollberg, and V. Mbele, Nature 445, 627 (2007).
[CrossRef] [PubMed]

Durr, N. J.

Fedder, G. K.

Flusberg, B. A.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Gmitro, F.

Goda, K.

K. Goda, K. K. Tsia, and B. Jalali, Nature 458, 1145 (2009).
[CrossRef] [PubMed]

Hasan, T.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Hollberg, L.

S. A. Diddams, L. Hollberg, and V. Mbele, Nature 445, 627 (2007).
[CrossRef] [PubMed]

Hoy, C. L.

Jalali, B.

K. Goda, K. K. Tsia, and B. Jalali, Nature 458, 1145 (2009).
[CrossRef] [PubMed]

Johnson, J.-A.

C. Rumack, S. Wilson, J. W. Charboneau, and J.-A. Johnson, Diagnostic Ultrasound (Mosby, 2004).

Jung, J. C.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Kirchner, M. S.

Ko, T. H.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Mbele, V.

S. A. Diddams, L. Hollberg, and V. Mbele, Nature 445, 627 (2007).
[CrossRef] [PubMed]

Motz, J. T.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Mukamel, E. A.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Nimeerjahn, A.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Pan, Y.

Piyawattanametha, W.

Ra, H.

Rizvi, I.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Rumack, C.

C. Rumack, S. Wilson, J. W. Charboneau, and J.-A. Johnson, Diagnostic Ultrasound (Mosby, 2004).

Schnitzer, M. J.

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Shirasaki, M.

Solgaard, O.

Soper, N. J.

N. J. Soper, Mastery of Endoscopic and Laparoscopic Surgery (Lippincott Williams & Wilkins, 2008).

Tearney, G. J.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Thorpe, M. J.

Tsia, K. K.

K. Goda, K. K. Tsia, and B. Jalali, Nature 458, 1145 (2009).
[CrossRef] [PubMed]

Weiner, A. M.

White, W. M.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Wilson, S.

C. Rumack, S. Wilson, J. W. Charboneau, and J.-A. Johnson, Diagnostic Ultrasound (Mosby, 2004).

Xiao, S.

Xie, H.

Ye, J.

Yelin, D.

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

Nat. Methods (1)

B. A. Flusberg, A. Nimeerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burn, J. C. Jung, and M. J. Schnitzer, Nat. Methods 5, 935 (2008).
[CrossRef] [PubMed]

Nature (3)

D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006).
[CrossRef] [PubMed]

S. A. Diddams, L. Hollberg, and V. Mbele, Nature 445, 627 (2007).
[CrossRef] [PubMed]

K. Goda, K. K. Tsia, and B. Jalali, Nature 458, 1145 (2009).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (3)

Other (2)

N. J. Soper, Mastery of Endoscopic and Laparoscopic Surgery (Lippincott Williams & Wilkins, 2008).

C. Rumack, S. Wilson, J. W. Charboneau, and J.-A. Johnson, Diagnostic Ultrasound (Mosby, 2004).

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Figures (3)

Fig. 1
Fig. 1

(a) Schematic of the SECOMM. OSA, optical spectrum analyzer; EDFA, erbium-doped fiber amplifier. (b) 2D spatial disperser that consists of a VIPA and a diffraction grating.

Fig. 2
Fig. 2

(a) Measured spectrum of the backreflected spectral shower from a reference target. (b) Image of the reference target after image reconstruction.

Fig. 3
Fig. 3

SECOMM images captured before (left) and after (right) laser ablation on a bovine tissue sample. The L pattern (dotted area) is carved out of the tissue by tuning the wavelength of the cw laser in the manner shown in the inset (see the arrow). The z axis represents the normalized reflectivity of the sample.

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