Abstract

A two-dimensional phase-detection system for a surface-plasmon-resonance sensor is presented. The sensor utilizes polarization interferometry to detect phase differences between the s and p polarizations. We successfully detected a spatial phase-difference variation, resulting from the biomolecular interactions, of less than 1×1mm2. The phase stability demonstrated in the experimental results was approximately 0.09°, and the corresponding change in the refractive index detection limit was approximately 4.3×106. The common-optical-path configuration of the proposed method allowed us to reduce disturbances from ambient conditions. Furthermore, this method is capable of real-time array detection.

© 2008 Optical Society of America

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References

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2007 (2)

P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1748 (2007).
[CrossRef]

J. Y. Lee, H. C. Shih, C. T. Hong, and T. K. Chou, Opt. Commun. 276, 283 (2007).
[CrossRef]

2006 (1)

2005 (2)

C. L. Wong, H. P. Ho, K. S. Chan, S. Y. Wu, and C. Lin, Opt. Eng. (Bellingham) 44, 124403 (2005).
[CrossRef]

S. J. Chen, Y. D. Su, F. M. Hsiu, C. Y. Tsou, and Y. K. Chen, J. Biomed. Opt. 10, 034005 (2005).
[CrossRef] [PubMed]

2004 (2)

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, Sens. Actuators B 99, 6 (2004).
[CrossRef]

H. P. Chiang, H. T. Yeh, C. M. Chen, J. C. Wu, S. Y. Su, R. Chang, Y. J. Wu, D. P. Tsai, S. U. Jen, and P. T. Leung, Opt. Commun. 241, 409 (2004).
[CrossRef]

2003 (1)

H. P. Ho and W. W. Lam, Sens. Actuators B 96, 554 (2003).
[CrossRef]

2001 (2)

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, Anal. Chem. 73, 1 (2001).
[CrossRef] [PubMed]

X. Liu, W. Clegg, D. F. L. Jenkins, and B. Liu, IEEE Trans. Instrum. Meas. 50, 868 (2001).
[CrossRef]

1996 (1)

S. G. Nelson, K. S. Johnston, and S. S. Yee, Sens. Actuators B 35, 187 (1996).
[CrossRef]

Anal. Chem. (1)

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, Anal. Chem. 73, 1 (2001).
[CrossRef] [PubMed]

IEEE Trans. Instrum. Meas. (1)

X. Liu, W. Clegg, D. F. L. Jenkins, and B. Liu, IEEE Trans. Instrum. Meas. 50, 868 (2001).
[CrossRef]

J. Biomed. Opt. (1)

S. J. Chen, Y. D. Su, F. M. Hsiu, C. Y. Tsou, and Y. K. Chen, J. Biomed. Opt. 10, 034005 (2005).
[CrossRef] [PubMed]

Opt. Commun. (2)

H. P. Chiang, H. T. Yeh, C. M. Chen, J. C. Wu, S. Y. Su, R. Chang, Y. J. Wu, D. P. Tsai, S. U. Jen, and P. T. Leung, Opt. Commun. 241, 409 (2004).
[CrossRef]

J. Y. Lee, H. C. Shih, C. T. Hong, and T. K. Chou, Opt. Commun. 276, 283 (2007).
[CrossRef]

Opt. Eng. (Bellingham) (1)

C. L. Wong, H. P. Ho, K. S. Chan, S. Y. Wu, and C. Lin, Opt. Eng. (Bellingham) 44, 124403 (2005).
[CrossRef]

Opt. Express (1)

P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1748 (2007).
[CrossRef]

Opt. Lett. (1)

Sens. Actuators B (3)

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, Sens. Actuators B 99, 6 (2004).
[CrossRef]

H. P. Ho and W. W. Lam, Sens. Actuators B 96, 554 (2003).
[CrossRef]

S. G. Nelson, K. S. Johnston, and S. S. Yee, Sens. Actuators B 35, 187 (1996).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Kretschmann’s configuration for the SPR and PI optical configurations. The + z axis is chosen to be along the direction of light propagation.

Fig. 2
Fig. 2

Spatial phase-difference distributions ϕ for the (a) initial and (b) final interactions. (c) The phase difference ϕ of the segment line between (a) and (b). (d) The temporal phase-difference variation Δ ϕ of the local biomolecular interaction area.

Fig. 3
Fig. 3

Results of real-time measurement of the four PBSs.

Equations (4)

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r q = r 12 q + r 23 q exp ( i 2 k z 2 d ) 1 + r 12 q r 23 q exp ( i 2 k z 2 d ) = r q exp ( i ϕ q ) ,
E 1 = J P 1 J Q J SPR E i = 1 2 [ cos α r p exp ( i ϕ p ) + i sin α r s exp ( i ϕ s ) 0 ] ,
I 1 = E 1 2 = A + B sin ( ϕ p ϕ s ) ,
ϕ = ϕ p ϕ s = tan 1 ( I 1 I 2 I 4 I 3 ) ,

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